3N5E
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor
Summary for 3N5E
Entry DOI | 10.2210/pdb3n5e/pdb |
Related | 3N5G |
Related PRD ID | PRD_000970 |
Descriptor | Thymidylate synthase, Synthetic peptide LR, SULFATE ION, ... (5 entities in total) |
Functional Keywords | peptide inhibitor, protein-peptide complex, interface inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P04818 P04818 |
Total number of polymer chains | 3 |
Total formula weight | 75962.80 |
Authors | Pozzi, C.,Cardinale, D.,Guaitoli, G.,Tondi, D.,Luciani, R.,Myllykallio, H.,Ferrari, S.,Costi, M.P.,Mangani, S. (deposition date: 2010-05-25, release date: 2011-06-08, Last modification date: 2023-09-06) |
Primary citation | Cardinale, D.,Guaitoli, G.,Tondi, D.,Luciani, R.,Henrich, S.,Salo-Ahen, O.M.,Ferrari, S.,Marverti, G.,Guerrieri, D.,Ligabue, A.,Frassineti, C.,Pozzi, C.,Mangani, S.,Fessas, D.,Guerrini, R.,Ponterini, G.,Wade, R.C.,Costi, M.P. Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. Proc.Natl.Acad.Sci.USA, 108:E542-E549, 2011 Cited by PubMed: 21795601DOI: 10.1073/pnas.1104829108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)