Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6P9M
DownloadVisualize
BU of 6p9m by Molmil
Crystal structure of Mycobacterium tuberculosis KasA in complex with O6J
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Capodagli, G.C, Neiditch, M.B.
Deposit date:2019-06-10
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.256 Å)
Cite:A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
Cell Chem Biol, 27, 2020
6QL5
DownloadVisualize
BU of 6ql5 by Molmil
Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 2.8 angstrom
Descriptor: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ...
Authors:Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A.
Deposit date:2019-01-31
Release date:2020-03-18
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6OKF
DownloadVisualize
BU of 6okf by Molmil
Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16-crypto Acyl Carrier Protein, AcpP
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ...
Authors:Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P.
Deposit date:2019-04-12
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Gating mechanism of elongating beta-ketoacyl-ACP synthases.
Nat Commun, 11, 2020
6OLT
DownloadVisualize
BU of 6olt by Molmil
Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C12-crypto Acyl Carrier Protein, AcpP
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
Authors:Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P.
Deposit date:2019-04-17
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Gating mechanism of elongating beta-ketoacyl-ACP synthases.
Nat Commun, 11, 2020
6QL6
DownloadVisualize
BU of 6ql6 by Molmil
Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom
Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ...
Authors:Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A.
Deposit date:2019-01-31
Release date:2020-03-18
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6QL7
DownloadVisualize
BU of 6ql7 by Molmil
Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 4.6 angstrom
Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17
Authors:Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A.
Deposit date:2019-01-31
Release date:2020-03-18
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (4.6 Å)
Cite:Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6QL9
DownloadVisualize
BU of 6ql9 by Molmil
Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom
Descriptor: 1,2-ETHANEDIOL, 4'-PHOSPHOPANTETHEINE, ACETATE ION, ...
Authors:Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A.
Deposit date:2019-01-31
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6QSP
DownloadVisualize
BU of 6qsp by Molmil
Ketosynthase (ApeO) in Complex with its Chain Length Factor (ApeC) from Xenorhabdus doucetiae
Descriptor: Beta-ketoacyl synthase, GLYCEROL, PHOSPHATE ION, ...
Authors:Grammbitter, G.L.C, Schmalhofer, M, Groll, M, Bode, H.
Deposit date:2019-02-21
Release date:2019-04-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments.
J.Am.Chem.Soc., 141, 2019
4JB6
DownloadVisualize
BU of 4jb6 by Molmil
Structure of Pseudomonas aeruginosa FabF mutant C164Q
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, POTASSIUM ION
Authors:Baum, B, Lecker, L.
Deposit date:2013-02-19
Release date:2014-03-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Pseudomonas aeruginosa beta-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.
Acta Crystallogr F Struct Biol Commun, 71, 2015
4JRH
DownloadVisualize
BU of 4jrh by Molmil
Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Vibrio Cholerae (space group P43) at 2.2 Angstrom
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, ACETATE ION
Authors:Hou, J, Chruszcz, M, Shabalin, I.G, Zheng, H, Cooper, D.R, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-03-21
Release date:2013-04-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:

4LS8
DownloadVisualize
BU of 4ls8 by Molmil
Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a covalent complex with cerulenin
Descriptor: (3R,7E,10E)-3-hydroxy-4-oxododeca-7,10-dienamide, 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ...
Authors:Trajtenberg, F, Larrieux, N, Buschiazzo, A.
Deposit date:2013-07-22
Release date:2014-04-02
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into bacterial resistance to cerulenin.
Febs J., 281, 2014
4JV3
DownloadVisualize
BU of 4jv3 by Molmil
Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with platencin
Descriptor: 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, Beta-ketoacyl synthase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
4JPF
DownloadVisualize
BU of 4jpf by Molmil
Structure of wild type Pseudomonas aeruginosa FabF (KASII) in Complex with ligand
Descriptor: 3-(benzoylamino)-2-hydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, MAGNESIUM ION, ...
Authors:Baum, B, Brenk, R, Jaenicke, E.
Deposit date:2013-03-19
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structures of Pseudomonas aeruginosa beta-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.
Acta Crystallogr F Struct Biol Commun, 71, 2015
4KC5
DownloadVisualize
BU of 4kc5 by Molmil
Crystal structure of the C-terminal part of RhiE from Burkholderia rhizoxinica
Descriptor: GLYCEROL, RhiE protein
Authors:Zocher, G, Heim, J.B, Stehle, T.
Deposit date:2013-04-24
Release date:2013-09-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Vinylogous chain branching catalysed by a dedicated polyketide synthase module.
Nature, 502, 2013
4JRM
DownloadVisualize
BU of 4jrm by Molmil
Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Vibrio Cholerae (space group P212121) at 1.75 Angstrom
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, ACETATE ION, GLYCEROL
Authors:Hou, J, Chruszcz, M, Shabalin, I.G, Zheng, H, Cooper, D.R, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-03-21
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Vibrio cholerae (space group P43) at 2.2 Angstrom
To be Published
4LS7
DownloadVisualize
BU of 4ls7 by Molmil
Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a non-covalent complex with cerulenin
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Cerulenin, GLYCEROL, ...
Authors:Trajtenberg, F, Larrieux, N, Buschiazzo, A.
Deposit date:2013-07-22
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.674 Å)
Cite:Structural insights into bacterial resistance to cerulenin.
Febs J., 281, 2014
4JGA
DownloadVisualize
BU of 4jga by Molmil
X-ray crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase 2 from Rickettsia rickettsii
Descriptor: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 2, POTASSIUM ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase 2 from Rickettsia rickettsii
To be Published
4LS5
DownloadVisualize
BU of 4ls5 by Molmil
Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Bacillus subtilis
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, GLYCEROL, POTASSIUM ION
Authors:Trajtenberg, F, Larrieux, N, Buschiazzo, A.
Deposit date:2013-07-22
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Structural insights into bacterial resistance to cerulenin.
Febs J., 281, 2014
4LS6
DownloadVisualize
BU of 4ls6 by Molmil
Crystal structure of beta-ketoacyl-ACP synthase II (FabF) I108F mutant from Bacillus subtilis
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, GLYCEROL, ...
Authors:Trajtenberg, F, Larrieux, N, Buschiazzo, A.
Deposit date:2013-07-22
Release date:2014-04-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural insights into bacterial resistance to cerulenin.
Febs J., 281, 2014
2RJT
DownloadVisualize
BU of 2rjt by Molmil
Crystal Structure Analysis of a Surface Entropy Reduction Mutant of S. pneumoniae FabF
Descriptor: Beta-ketoacyl-ACP synthase II
Authors:Soisson, S.M, Parthasarathy, G, Becker, J.
Deposit date:2007-10-15
Release date:2008-01-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae.
Acta Crystallogr.,Sect.D, 64, 2008
2VKZ
DownloadVisualize
BU of 2vkz by Molmil
Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex
Descriptor: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, FATTY ACID SYNTHASE SUBUNIT ALPHA, ...
Authors:Johansson, P, Wiltschi, B, Kumari, P, Kessler, B, Vonrhein, C, Vonck, J, Oesterhelt, D, Grininger, M.
Deposit date:2008-01-07
Release date:2008-08-12
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (4 Å)
Cite:Inhibition of the Fungal Fatty Acid Synthase Type I Multienzyme Complex.
Proc.Natl.Acad.Sci.USA, 105, 2008
2VB9
DownloadVisualize
BU of 2vb9 by Molmil
beta-ketoacyl-ACP synthase I (KAS) from E. coli, apo structure
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, CHLORIDE ION
Authors:Pappenberger, G, Schulz-Gasch, T, Bailly, J, Hennig, M.
Deposit date:2007-09-06
Release date:2007-12-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis.
Acta Crystallogr.,Sect.D, 63, 2007
2WGD
DownloadVisualize
BU of 2wgd by Molmil
Crystal structure of KasA of Mycobacterium tuberculosis
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Luckner, S.R, Kisker, C.
Deposit date:2009-04-17
Release date:2009-07-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin
Structure, 17, 2009
2WGE
DownloadVisualize
BU of 2wge by Molmil
Crystal structure of KasA of Mycobacterium tuberculosis with bound TLM
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Luckner, S.R, Kisker, C.
Deposit date:2009-04-17
Release date:2009-07-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin
Structure, 17, 2009
2WGG
DownloadVisualize
BU of 2wgg by Molmil
Crystal Structure of Mycobacterium tuberculosis C171Q KasA variant with bound TLM
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, NONAETHYLENE GLYCOL, ...
Authors:Luckner, S.R, Kisker, C.
Deposit date:2009-04-17
Release date:2009-07-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin
Structure, 17, 2009

221051

数据于2024-06-12公开中

PDB statisticsPDBj update infoContact PDBjnumon