PDB: 97922 resultsInfo pagesStatus searchChemie searchBIRD

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5TYA	Identification of a New Zinc Binding Chemotype by Fragment Screening Descriptor: (5R)-5-phenyl-1,3-thiazolidine-2,4-dione, Carbonic anhydrase 2, ZINC ION Authors: Peat, T.S, Poulsen, S.A, Ren, B, Dolezal, O, Woods, L.A, Mujumdar, P, Chrysanthopoulos, P.K. Deposit date: 2016-11-18 Release date: 2017-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60, 2017
6FKZ	Crystal structure of zebrafish Sirtuin 5 in complex with 3-(phenylthio)succinyl-CPS1 peptide Descriptor: 3(R)-(phenylthio)succinyl-CPS1 peptide, 3(S)-(phenylthio)succinyl-CPS1 peptide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Pannek, M, Steegborn, C. Deposit date: 2018-01-25 Release date: 2018-05-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Potent and Selective Inhibitors of Human Sirtuin 5. J. Med. Chem., 61, 2018
7S9E	Cryo-EM Structure of dolphin Prestin: Inhibited II (Sulfate +Salicylate) state Descriptor: 2-HYDROXYBENZOIC ACID, Prestin Authors: Bavi, N, Clark, M.D, Contreras, G.F, Shen, R, Reddy, B.G, Milewski, W, Perozo, E. Deposit date: 2021-09-20 Release date: 2021-11-03 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: The conformational cycle of prestin underlies outer-hair cell electromotility. Nature, 600, 2021
7S8X	Cryo-EM Structure of dolphin Prestin: Sensor Up (compact) state Descriptor: Prestin Authors: Bavi, N, Clark, M.D, Contreras, G.F, Shen, R, Reddy, B.G, Milewski, W, Perozo, E. Deposit date: 2021-09-20 Release date: 2021-11-03 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The conformational cycle of prestin underlies outer-hair cell electromotility. Nature, 600, 2021
7S9C	Cryo-EM Structure of dolphin Prestin: Sensor Down II (Expanded II) state Descriptor: Prestin Authors: Bavi, N, Clark, M.D, Contreras, G.F, Shen, R, Reddy, B.G, Milewski, W, Perozo, E. Deposit date: 2021-09-20 Release date: 2021-11-03 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (6.7 Å) Cite: The conformational cycle of prestin underlies outer-hair cell electromotility. Nature, 600, 2021
7S9D	Cryo-EM Structure of dolphin Prestin: Intermediate state Descriptor: Prestin Authors: Bavi, N, Clark, M.D, Contreras, G.F, Shen, R, Reddy, B.G, Milewski, W, Perozo, E. Deposit date: 2021-09-20 Release date: 2021-11-03 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: The conformational cycle of prestin underlies outer-hair cell electromotility. Nature, 600, 2021
7O3B	Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody Descriptor: Nanobody 36Z, Tau-tubulin kinase 2,Centrosomal protein of 164 kDa Authors: e Silva, I.R, van Breugel, M. Deposit date: 2021-04-01 Release date: 2021-09-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies. Structure, 30, 2022
7S9A	Cryo-EM Structure of dolphin Prestin: Inhibited I (Chloride + Salicylate) Descriptor: 2-HYDROXYBENZOIC ACID, Prestin Authors: Bavi, N, Clark, M.D, Contreras, G.F, Shen, R, Reddy, B.G, Milewski, W, Perozo, E. Deposit date: 2021-09-20 Release date: 2021-11-03 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: The conformational cycle of prestin underlies outer-hair cell electromotility. Nature, 600, 2021
7O0S	Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 36Z Descriptor: Centrosomal protein of 164 kDa, Nanobody 36Z Authors: e Silva, I.R, van Breugel, M. Deposit date: 2021-03-26 Release date: 2021-09-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies. Structure, 30, 2022
7S9B	Cryo-EM Structure of dolphin Prestin: Sensor Down I (Expanded) state Descriptor: Prestin Authors: Bavi, N, Clark, M.D, Contreras, G.F, Shen, R, Reddy, B.G, Milewski, W, Perozo, E. Deposit date: 2021-09-20 Release date: 2021-11-03 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: The conformational cycle of prestin underlies outer-hair cell electromotility. Nature, 600, 2021
4HS2	Crystal Structure of the Human SPOP C-terminal Domain Descriptor: Speckle-type POZ protein Authors: Van Geersdaele, L.K, Stead, M.A, Carr, S.B, Wright, S.C. Deposit date: 2012-10-29 Release date: 2013-09-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP. Acta Crystallogr.,Sect.D, 69, 2013
6CB1	Yeast nucleolar pre-60S ribosomal subunit (state 3) Descriptor: 35S pre-ribosomal RNA miscRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ... Authors: Sanghai, Z.A, Miller, L, Barandun, J, Hunziker, M, Chaker-Margot, M, Klinge, S. Deposit date: 2018-02-01 Release date: 2018-03-14 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Modular assembly of the nucleolar pre-60S ribosomal subunit. Nature, 556, 2018
2YJW	Tricyclic series of Hsp90 inhibitors Descriptor: 4-(5-METHYL-4-PHENYLISOXAZOL-3-YL)BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA Authors: Dupuy, A, Vallee, F. Deposit date: 2011-05-24 Release date: 2011-10-19 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
5U0F	Identification of a New Zinc Binding Chemotype by Fragment Screening Descriptor: (5R)-5-[(2,4-dimethoxyphenyl)methyl]-2-sulfanylidene-1,3-thiazolidin-4-one, Carbonic anhydrase 2, ZINC ION Authors: Peat, T.S, Poulsen, S.A, Ren, B, Dolezal, O, Woods, L.A, Mujumdar, P, Chrysanthopoulos, P.K. Deposit date: 2016-11-23 Release date: 2017-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.21 Å) Cite: Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60, 2017
1NNU	Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase with Triclosan Analog Descriptor: 6-(4-CHLORO-2-HYDROXY-PHENOXY)-NAPHTHALEN-2-OL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase Authors: Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. Deposit date: 2003-01-14 Release date: 2003-02-25 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase J.Biol.Chem., 277, 2002
5TY9	Identification of a New Zinc Binding Chemotype by Fragment Screening Descriptor: (5R)-5-(2,4-dimethoxyphenyl)-1,3-oxazolidine-2,4-dione, Carbonic anhydrase 2, ZINC ION Authors: Peat, T.S, Poulsen, S.A, Ren, B, Dolezal, O, Woods, L.A, Mujumdar, P, Chrysanthopoulos, P.K. Deposit date: 2016-11-18 Release date: 2017-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60, 2017
4EU1	Structure of a mitochondrial aspartate aminotransferase from Trypanosoma brucei Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Mitochondrial aspartate aminotransferase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-04-25 Release date: 2012-05-16 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia. Acta Crystallogr F Struct Biol Commun, 71, 2015
2BGU	CRYSTAL STRUCTURE OF THE DNA MODIFYING ENZYME BETA-GLUCOSYLTRANSFERASE IN THE PRESENCE AND ABSENCE OF THE SUBSTRATE URIDINE DIPHOSPHOGLUCOSE Descriptor: BETA-GLUCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE Authors: Vrielink, A, Rueger, W, Driessen, H.P.C, Freemont, P.S. Deposit date: 1994-06-09 Release date: 1995-12-09 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of the DNA modifying enzyme beta-glucosyltransferase in the presence and absence of the substrate uridine diphosphoglucose. EMBO J., 13, 1994
3OJ2	Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation Descriptor: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION Authors: Beenken, A, Mohammadi, M. Deposit date: 2010-08-20 Release date: 2011-08-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287, 2012
1OAA	MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND OXALOACETATE Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, OXALOACETATE ION, SEPIAPTERIN REDUCTASE, ... Authors: Auerbach, G, Herrmann, A, Bacher, A, Huber, R. Deposit date: 1997-08-25 Release date: 1999-02-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.25 Å) Cite: The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. EMBO J., 16, 1997
7RXH	afTMEM16 in C18 lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+, monomer with extra lipids Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, afTMEM16 lipid scramblase Authors: Falzone, M.E, Accardi, A. Deposit date: 2021-08-23 Release date: 2022-05-18 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (2.3 Å) Cite: TMEM16 scramblases thin the membrane to enable lipid scrambling. Nat Commun, 13, 2022
2BTC	BOVINE TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA PEPO TRYPSIN INHIBITOR II) Descriptor: CALCIUM ION, PROTEIN (TRYPSIN INHIBITOR), PROTEIN (TRYPSIN) Authors: Helland, R, Berglund, G.I, Otlewski, J, Apostoluk, W, Andersen, O.A, Willassen, N.P, Smalas, A.O. Deposit date: 1998-12-11 Release date: 2000-01-19 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.5 Å) Cite: High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes. Acta Crystallogr.,Sect.D, 55, 1999
1NT9	Complete 12-subunit RNA polymerase II Descriptor: DNA-DIRECTED RNA POLYMERASE II 13.6 KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 19 KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT, ... Authors: Armache, K.-J, Kettenberger, H, Cramer, P. Deposit date: 2003-01-29 Release date: 2003-04-22 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (4.2 Å) Cite: Architecture of initiation-competent 12-subunit RNA polymerase II Proc.Natl.Acad.Sci.USA, 100, 2003
8CNK	Cryo-EM structure of retinal-free proteoopsin bound to decanoate Descriptor: DECANOIC ACID, Green-light absorbing proteorhodopsin Authors: Hirschi, S, Lemmin, T, Fotiadis, D. Deposit date: 2023-02-23 Release date: 2024-07-03 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Structural insights into the mechanism and dynamics of proteorhodopsin biogenesis and retinal scavenging. Nat Commun, 15, 2024
6CHA	STRUCTURE OF A TETRAHEDRAL TRANSITION STATE COMPLEX OF ALPHA-*CHYMOTRYPSIN AT 1.8-*ANGSTROMS RESOLUTION Descriptor: ALPHA-CHYMOTRYPSIN A, PHENYLETHANE BORONIC ACID Authors: Tulinsky, A, Blevins, R.A. Deposit date: 1987-02-06 Release date: 1987-04-16 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of a tetrahedral transition state complex of alpha-chymotrypsin dimer at 1.8-A resolution. J.Biol.Chem., 262, 1987

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