7S9A

Cryo-EM Structure of dolphin Prestin: Inhibited I (Chloride + Salicylate)

Summary for 7S9A

• Entry DOI: 10.2210/pdb7s9a/pdb
• EMDB information: 24930
• Descriptor: Prestin, 2-HYDROXYBENZOIC ACID (2 entities in total)
• Functional Keywords: outer hair cells, electromotility, mechanotransduction, hearing, deafness, frequency sensation, echolocation, slc26, slc26a5, motor protein
• Biological source: Tursiops truncatus (Atlantic bottle-nosed dolphin, Delphinus truncatus)
• Total number of polymer chains: 2
• Total formula weight: 162223.74

Authors

Bavi, N.,Clark, M.D.,Contreras, G.F.,Shen, R.,Reddy, B.G.,Milewski, W.,Perozo, E. (deposition date: 2021-09-20, release date: 2021-11-03, Last modification date: 2021-12-29)

• Primary citation: Bavi, N.,Clark, M.D.,Contreras, G.F.,Shen, R.,Reddy, B.G.,Milewski, W.,Perozo, E.; The conformational cycle of prestin underlies outer-hair cell electromotility.; Nature, 600:553-558, 2021; PubMed: 34695838; DOI: 10.1038/s41586-021-04152-4

Experimental method

ELECTRON MICROSCOPY (3.8 Å)