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5U0F

Identification of a New Zinc Binding Chemotype by Fragment Screening

Summary for 5U0F
Entry DOI10.2210/pdb5u0f/pdb
Related5TY1 5TY8 5TY9 5TYA 5U0D 5U0E 5U0G
DescriptorCarbonic anhydrase 2, ZINC ION, (5R)-5-[(2,4-dimethoxyphenyl)methyl]-2-sulfanylidene-1,3-thiazolidin-4-one, ... (4 entities in total)
Functional Keywordsfragment screening, carbonic anhydrase, lyase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P00918
Total number of polymer chains1
Total formula weight29637.84
Authors
Peat, T.S.,Poulsen, S.A.,Ren, B.,Dolezal, O.,Woods, L.A.,Mujumdar, P.,Chrysanthopoulos, P.K. (deposition date: 2016-11-23, release date: 2017-08-30, Last modification date: 2023-10-04)
Primary citationChrysanthopoulos, P.K.,Mujumdar, P.,Woods, L.A.,Dolezal, O.,Ren, B.,Peat, T.S.,Poulsen, S.A.
Identification of a New Zinc Binding Chemotype by Fragment Screening.
J. Med. Chem., 60:7333-7349, 2017
Cited by
PubMed: 28817930
DOI: 10.1021/acs.jmedchem.7b00606
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.21 Å)
Structure validation

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