5U0E
Identification of a New Zinc Binding Chemotype by Fragment Screening
Summary for 5U0E
Entry DOI | 10.2210/pdb5u0e/pdb |
Related | 5TY1 5TY8 5TY9 5TYA 5U0D 5U0F 5U0G |
Descriptor | Carbonic anhydrase 2, ZINC ION, (5R)-5-benzyl-2-sulfanylidene-1,3-thiazolidin-4-one, ... (6 entities in total) |
Functional Keywords | fragment screening, carbonic anhydrase, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29731.95 |
Authors | Peat, T.S.,Poulsen, S.A.,Ren, B.,Dolezal, O.,Woods, L.A.,Mujumdar, P.,Chrysanthopoulos, P.K. (deposition date: 2016-11-23, release date: 2017-08-30, Last modification date: 2023-10-04) |
Primary citation | Chrysanthopoulos, P.K.,Mujumdar, P.,Woods, L.A.,Dolezal, O.,Ren, B.,Peat, T.S.,Poulsen, S.A. Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60:7333-7349, 2017 Cited by PubMed: 28817930DOI: 10.1021/acs.jmedchem.7b00606 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.27 Å) |
Structure validation
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