5A3Q
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![BU of 5a3q by Molmil](/molmil-images/mine/5a3q) | Crystal structure of the (SR) Calcium ATPase E2-vanadate complex bound to thapsigargin and TNP-AMPPCP | Descriptor: | CHLORIDE ION, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Clausen, J.D, Bublitz, M, Arnou, B, Olesen, C, Andersen, J.P, Moller, J.V, Nissen, P. | Deposit date: | 2015-06-02 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase. Structure, 24, 2016
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8IQ6
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![BU of 8iq6 by Molmil](/molmil-images/mine/8iq6) | Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X. | Deposit date: | 2023-03-15 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity. Nat Commun, 14, 2023
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8IQ4
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![BU of 8iq4 by Molmil](/molmil-images/mine/8iq4) | Cryo-EM structure of Carboprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X. | Deposit date: | 2023-03-15 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity. Nat Commun, 14, 2023
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5A3S
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![BU of 5a3s by Molmil](/molmil-images/mine/5a3s) | Crystal structure of the (SR) Calcium ATPase E2-vanadate complex bound to thapsigargin and TNP-ATP | Descriptor: | CHLORIDE ION, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Clausen, J.D, Bublitz, M, Arnou, B, Olesen, C, Andersen, J.P, Moller, J.V, Nissen, P. | Deposit date: | 2015-06-03 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase. Structure, 24, 2016
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8I40
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![BU of 8i40 by Molmil](/molmil-images/mine/8i40) | Crystal structure of ASCT from Trypanosoma brucei in complex with CoA. | Descriptor: | ACETATE ION, CALCIUM ION, COENZYME A, ... | Authors: | Mochizuki, K, Inaoka, D.K, Fukuda, K, Kurasawa, H, Iyoda, K, Nakai, U, Harada, S, Balogun, E.O, Mazet, M, Millerioux, Y, Bringaud, F, Boshart, M, Hirayama, K, Kita, K, Shiba, T. | Deposit date: | 2023-01-18 | Release date: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Crystal structure of ligand complexes of ASCT from Trypanosoma brucei and molecular mechanism in comparison with mammalian SCOT. To Be Published
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1K0I
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![BU of 1k0i by Molmil](/molmil-images/mine/1k0i) | Pseudomonas aeruginosa phbh R220Q in complex with 100mM PHB | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOATE HYDROXYLASE, P-HYDROXYBENZOIC ACID, ... | Authors: | Wang, J, Ortiz-Maldonado, M, Entsch, B, Ballou, D, Gatti, D.L. | Deposit date: | 2001-09-19 | Release date: | 2002-02-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase. Proc.Natl.Acad.Sci.USA, 99, 2002
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1R31
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![BU of 1r31 by Molmil](/molmil-images/mine/1r31) | HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA | Descriptor: | (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ... | Authors: | Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. | Deposit date: | 2003-09-30 | Release date: | 2003-10-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase. To be Published
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6AZ4
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![BU of 6az4 by Molmil](/molmil-images/mine/6az4) | RNA hairpin complex with guanosine dinucleotide ligand G(5')ppp(5')G | Descriptor: | DIGUANOSINE-5'-TRIPHOSPHATE, RNA (32-MER), RNA (5'-R(*CP*AP*GP*CP*AP*GP*CP*AP*G)-3') | Authors: | Zhang, W, Szostak, J.W. | Deposit date: | 2017-09-09 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide. J. Am. Chem. Soc., 140, 2018
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8J1F
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![BU of 8j1f by Molmil](/molmil-images/mine/8j1f) | GSK101 bound state of mTRPV4 | Descriptor: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1D
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![BU of 8j1d by Molmil](/molmil-images/mine/8j1d) | Cryo-EM structure of apo state mTRPV4 | Descriptor: | Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1H
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![BU of 8j1h by Molmil](/molmil-images/mine/8j1h) | Agonist1 and Ruthenium Red bound state of mTRPV4 | Descriptor: | 8-fluoranyl-3-[4-(4-fluoranylphenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one, Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1B
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![BU of 8j1b by Molmil](/molmil-images/mine/8j1b) | GSK101 and Ruthenium Red bound state of mTRPV4 | Descriptor: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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1PKV
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![BU of 1pkv by Molmil](/molmil-images/mine/1pkv) | The N-terminal domain of riboflavin synthase in complex with riboflavin | Descriptor: | RIBOFLAVIN, Riboflavin synthase alpha chain | Authors: | Meining, W, Eberhardt, S, Bacher, A, Ladenstein, R. | Deposit date: | 2003-06-06 | Release date: | 2004-06-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution. J.Mol.Biol., 331, 2003
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1JWR
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![BU of 1jwr by Molmil](/molmil-images/mine/1jwr) | Crystal structure of human lysozyme at 100 K | Descriptor: | lysozyme | Authors: | Higo, J, Nakasako, M. | Deposit date: | 2001-09-05 | Release date: | 2001-09-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Hydration structure of human lysozyme investigated by molecular dynamics simulation and cryogenic X-ray crystal structure analyses: on the correlation between crystal water sites, solvent density, and solvent dipole J.Comput.Chem., 23, 2002
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1QGE
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![BU of 1qge by Molmil](/molmil-images/mine/1qge) | NEW CRYSTAL FORM OF PSEUDOMONAS GLUMAE (FORMERLY CHROMOBACTERIUM VISCOSUM ATCC 6918) LIPASE | Descriptor: | CALCIUM ION, PROTEIN (TRIACYLGLYCEROL HYDROLASE) | Authors: | Lang, D.A, Stadler, P, Kovacs, A, Paltauf, F, Dijkstra, B.W. | Deposit date: | 1999-04-27 | Release date: | 1999-05-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Kinetic Investigations of Enantiomeric Binding Mode of Subclass I Lipases from the Family of Pseudomonadaceae To be Published
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8JKM
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![BU of 8jkm by Molmil](/molmil-images/mine/8jkm) | RN-1747 bound state of mTRPV4 | Descriptor: | Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-06-01 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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2AO6
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![BU of 2ao6 by Molmil](/molmil-images/mine/2ao6) | Crystal structure of the human androgen receptor ligand binding domain bound with TIF2(iii) 740-753 peptide and R1881 | Descriptor: | (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE, 14-mer fragment of Nuclear receptor coactivator 2, androgen receptor | Authors: | He, B, Gampe Jr, R.T, Kole, A.J, Hnat, A.T, Stanley, T.B, An, G, Stewart, E.L, Kalman, R.I, Minges, J.T, Wilson, E.M. | Deposit date: | 2005-08-12 | Release date: | 2005-08-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance Mol.Cell, 16, 2004
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6GLC
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![BU of 6glc by Molmil](/molmil-images/mine/6glc) | Structure of phospho-Parkin bound to phospho-ubiquitin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | Authors: | Gladkova, C, Maslen, S.L, Skehel, J.M, Komander, D. | Deposit date: | 2018-05-23 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanism of parkin activation by PINK1. Nature, 559, 2018
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4C12
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![BU of 4c12 by Molmil](/molmil-images/mine/4c12) | X-ray Crystal Structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Fulop, V, Roper, D.I, Ruane, K.M, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J. | Deposit date: | 2013-08-09 | Release date: | 2013-10-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Specificity Determinants for Lysine Incorporation in Staphylococcus Aureus Peptidoglycan as Revealed by the Structure of a Mure Enzyme Ternary Complex. J.Biol.Chem., 288, 2013
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7ESK
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![BU of 7esk by Molmil](/molmil-images/mine/7esk) | Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, Ligand free form | Descriptor: | CALCIUM ION, L-Rhamnose-alpha-1,4-D-glucuronate lyase, SODIUM ION, ... | Authors: | Kondo, T, Arakawa, T, Fushinobu, S, Sakamoto, T. | Deposit date: | 2021-05-11 | Release date: | 2021-08-04 | Last modified: | 2021-09-01 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structural and functional analysis of gum arabic l-rhamnose-alpha-1,4-d-glucuronate lyase establishes a novel polysaccharide lyase family. J.Biol.Chem., 297, 2021
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3ZKI
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![BU of 3zki by Molmil](/molmil-images/mine/3zki) | BACE2 MUTANT STRUCTURE WITH LIGAND | Descriptor: | 5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-2-amino-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-4-yl)-phenyl]-amide, BETA-SECRETASE 2 | Authors: | Banner, D.W, Kuglstatter, A, Benz, J, Stihle, M, Ruf, A. | Deposit date: | 2013-01-23 | Release date: | 2013-05-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D, 69, 2013
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1K0J
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![BU of 1k0j by Molmil](/molmil-images/mine/1k0j) | Pseudomonas aeruginosa phbh R220Q in complex with NADPH and free of p-OHB | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, P-HYDROXYBENZOATE HYDROXYLASE, ... | Authors: | Wang, J, Ortiz-Maldonado, M, Entsch, B, Ballou, D, Gatti, D.L. | Deposit date: | 2001-09-19 | Release date: | 2002-02-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase. Proc.Natl.Acad.Sci.USA, 99, 2002
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5W9C
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![BU of 5w9c by Molmil](/molmil-images/mine/5w9c) | |
6DJ7
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![BU of 6dj7 by Molmil](/molmil-images/mine/6dj7) | HIV-1 protease with mutation L76V in complex with GRL-5010 (gem-difluoro-bis-tetrahydrofuran as P2 ligand) | Descriptor: | (3R,3aS,6aS)-4,4-difluorohexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, ACETATE ION, CHLORIDE ION, ... | Authors: | Wong-Sam, A.E, Wang, Y.F, Weber, I.T. | Deposit date: | 2018-05-24 | Release date: | 2018-10-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. ACS Omega, 3, 2018
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1JVT
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![BU of 1jvt by Molmil](/molmil-images/mine/1jvt) | |