5A3S

Crystal structure of the (SR) Calcium ATPase E2-vanadate complex bound to thapsigargin and TNP-ATP

Summary for 5A3S

• Entry DOI: 10.2210/pdb5a3s/pdb
• Related: 5A3Q 5A3R
• Descriptor: SARCOPLASMIC RETICULUM CALCIUM ATPASE 1 MOLECULE SARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE 1, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z), 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OX Y]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER, oxido(dioxo)vanadium, ... (8 entities in total)
• Functional Keywords: hydrolase, sarco(endo)plasmic reticulum calcium atpase, beryllium fluoride, p-type atpase, serca, trinitrophenyl-nucleotide analoges, tnp-atp, calcium transport, inhibition, transition state
• Biological source: ORYCTOLAGUS CUNICULUS (RABBIT)
• Total number of polymer chains: 2
• Total formula weight: 222439.48

Authors

Clausen, J.D.,Bublitz, M.,Arnou, B.,Olesen, C.,Andersen, J.P.,Moller, J.V.,Nissen, P. (deposition date: 2015-06-03, release date: 2016-04-13, Last modification date: 2024-01-10)

• Primary citation: Clausen, J.D.,Bublitz, M.,Arnou, B.,Olesen, C.,Andersen, J.P.,Moller, J.V.,Nissen, P.; Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase.; Structure, 24:617-, 2016; PubMed: 27050689; DOI: 10.1016/J.STR.2016.02.018

Experimental method

X-RAY DIFFRACTION (3.3 Å)