2QT4
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![BU of 2qt4 by Molmil](/molmil-images/mine/2qt4) | Atomic-resolution crystal structure of the natural form of Scytovirin | Descriptor: | scytovirin | Authors: | Moulaei, T, Botos, I, Ziolkowska, N.E, Dauter, Z, Wlodawer, A. | Deposit date: | 2007-08-01 | Release date: | 2007-11-27 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Sci., 16, 2007
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2QTM
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2QTV
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![BU of 2qtv by Molmil](/molmil-images/mine/2qtv) | Structure of Sec23-Sar1 complexed with the active fragment of Sec31 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein transport protein SEC23, ... | Authors: | Goldberg, J, Bi, X, Mancias, J.D. | Deposit date: | 2007-08-02 | Release date: | 2008-01-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31. Dev.Cell, 13, 2007
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2OLU
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![BU of 2olu by Molmil](/molmil-images/mine/2olu) | Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme | Descriptor: | 1,2-ETHANEDIOL, Penicillin-binding protein 2 | Authors: | Lovering, A.L, De Castro, L.H, Lim, D, Strynadka, N.C. | Deposit date: | 2007-01-19 | Release date: | 2007-03-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis. Science, 315, 2007
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2OPH
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![BU of 2oph by Molmil](/molmil-images/mine/2oph) | Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Scapin, G, Weber, A.E, Duffy, J.L. | Deposit date: | 2007-01-29 | Release date: | 2007-05-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | 4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV. Bioorg.Med.Chem.Lett., 17, 2007
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3QCS
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![BU of 3qcs by Molmil](/molmil-images/mine/3qcs) | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-[2-Amino-6-(4-morpholinyl)-4-pyrimidinyl]-1H-indazol-3-amine | Descriptor: | 3-phosphoinositide-dependent protein kinase 1, 6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2H-indazol-3-amine, GLYCEROL, ... | Authors: | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | Deposit date: | 2011-01-17 | Release date: | 2011-03-09 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.487 Å) | Cite: | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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3GPP
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![BU of 3gpp by Molmil](/molmil-images/mine/3gpp) | MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC3-T224P complex | Descriptor: | DNA (5'-D(P*CP*GP*TP*CP*CP*(8OG)P*GP*AP*TP*CP*TP*AP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*GP*AP*TP*CP*CP*GP*GP*AP*C)-3'), DNA glycosylase, ... | Authors: | Spong, M.C, Qi, Y, Verdine, G.L. | Deposit date: | 2009-03-23 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature, 462, 2009
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3GVV
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![BU of 3gvv by Molmil](/molmil-images/mine/3gvv) | Single-chain UROD Y164G (GY) mutation | Descriptor: | Uroporphyrinogen decarboxylase | Authors: | Hill, C.P, Phillips, J.D, Whitby, F.G, Warby, C, Kushner, J.P. | Deposit date: | 2009-03-31 | Release date: | 2009-07-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen. J.Mol.Biol., 389, 2009
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3GPY
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![BU of 3gpy by Molmil](/molmil-images/mine/3gpy) | Sequence-matched MutM Lesion Recognition Complex 3 (LRC3) | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*TP*CP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*T*GP*CP*GP*TP*CP*CP*(8OG)P*GP*AP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | Authors: | Qi, Y, Verdine, G.L. | Deposit date: | 2009-03-23 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature, 462, 2009
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3GW5
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![BU of 3gw5 by Molmil](/molmil-images/mine/3gw5) | Crystal structure of human renin complexed with a novel inhibitor | Descriptor: | (3R)-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wu, Z, McKeever, B.M. | Deposit date: | 2009-03-31 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorg.Med.Chem.Lett., 19, 2009
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3GWM
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3GWV
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![BU of 3gwv by Molmil](/molmil-images/mine/3gwv) | Leucine transporter LeuT in complex with R-fluoxetine | Descriptor: | (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ... | Authors: | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | Deposit date: | 2009-04-01 | Release date: | 2009-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol., 16, 2009
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2ONB
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![BU of 2onb by Molmil](/molmil-images/mine/2onb) | Human Thymidylate Synthase at low salt conditions with PDPA bound | Descriptor: | 1,2-ETHANEDIOL, PROPANE-1,3-DIYLBIS(PHOSPHONIC ACID), SULFATE ION, ... | Authors: | Lovelace, L.L, Gibson, L.M, Lebioda, L. | Deposit date: | 2007-01-23 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors Biochemistry, 46, 2007
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2OLV
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![BU of 2olv by Molmil](/molmil-images/mine/2olv) | Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex | Descriptor: | MOENOMYCIN, Penicillin-binding protein 2 | Authors: | Lovering, A.L, De Castro, L, Lim, D, Strynadka, N.C.J. | Deposit date: | 2007-01-19 | Release date: | 2007-03-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis. Science, 315, 2007
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2OP9
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3TU6
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![BU of 3tu6 by Molmil](/molmil-images/mine/3tu6) | The Structure of a Pseudoazurin From Sinorhizobium meliltoi | Descriptor: | COPPER (II) ION, GLYCEROL, Pseudoazurin (Blue copper protein) | Authors: | Laming, E.M, McGrath, A.P, Guss, J.M, Maher, M.J. | Deposit date: | 2011-09-16 | Release date: | 2012-05-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The X-ray crystal structure of a pseudoazurin from Sinorhizobium meliloti. J.Inorg.Biochem., 115, 2012
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3TL4
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2OPE
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![BU of 2ope by Molmil](/molmil-images/mine/2ope) | Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43 | Descriptor: | PilX | Authors: | Dyer, D.H, Helaine, S, Pelicic, V, Forest, K.T. | Deposit date: | 2007-01-29 | Release date: | 2007-10-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | 3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili. Proc.Natl.Acad.Sci.Usa, 104, 2007
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3H0V
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![BU of 3h0v by Molmil](/molmil-images/mine/3h0v) | Human AdoMetDC with 5'-Deoxy-5'-(dimethylsulfonio) adenosine | Descriptor: | 1,4-DIAMINOBUTANE, 5'-deoxy-5'-(dimethyl-lambda~4~-sulfanyl)adenosine, PYRUVIC ACID, ... | Authors: | Bale, S, Brooks, W.H, Hanes, J.W, Mahesan, A.M, Guida, W.C, Ealick, S.E. | Deposit date: | 2009-04-10 | Release date: | 2009-06-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase. Biochemistry, 48, 2009
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3TVU
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![BU of 3tvu by Molmil](/molmil-images/mine/3tvu) | Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 3 | Descriptor: | 4-({4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl}carbonyl)-2-phenylquinoline, Acetyl-CoA carboxylase | Authors: | Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F. | Deposit date: | 2011-09-20 | Release date: | 2011-10-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion. J.Biol.Chem., 286, 2011
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2OLJ
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![BU of 2olj by Molmil](/molmil-images/mine/2olj) | ABC Protein ArtP in complex with ADP/Mg2+ | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Amino acid ABC transporter, GLYCEROL, ... | Authors: | Thaben, P.F, Eckey, V, Scheffel, F, Saenger, W, Schneider, E, Vahedi-Faridi, A. | Deposit date: | 2007-01-19 | Release date: | 2008-01-15 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structures of the ATP-binding cassette (ABC) protein ArtP from Geobacillus stearothermophilus reveal a stable dimer in the post hydrolysis state and an asymmetry in the dimerization region To be Published
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2OLW
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![BU of 2olw by Molmil](/molmil-images/mine/2olw) | Crystal Structure of E. coli pseudouridine synthase RluE | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETIC ACID, Ribosomal large subunit pseudouridine synthase E, ... | Authors: | Pan, H, Ho, J.D, Stroud, R.M, Finer-Moore, J. | Deposit date: | 2007-01-19 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE. J.Mol.Biol., 367, 2007
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3H05
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![BU of 3h05 by Molmil](/molmil-images/mine/3h05) | The Crystal Structure of a Putative Nicotinate-nucleotide Adenylyltransferase from Vibrio parahaemolyticus | Descriptor: | CHLORIDE ION, uncharacterized protein VPA0413 | Authors: | Stein, A.J, Cuff, M.E, Sather, A, Shackelford, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-04-08 | Release date: | 2009-04-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Crystal Structure of a Putative Nicotinate-nucleotide Adenylyltransferase from Vibrio parahaemolyticus To be Published
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3TPA
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3H0B
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![BU of 3h0b by Molmil](/molmil-images/mine/3h0b) | Discovery of aminoheterocycles as a novel beta-secretase inhibitor class | Descriptor: | 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine, Beta-secretase 1 | Authors: | Allison, T.J. | Deposit date: | 2009-04-08 | Release date: | 2009-07-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1. Bioorg.Med.Chem.Lett., 19, 2009
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