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3H0B

Discovery of aminoheterocycles as a novel beta-secretase inhibitor class

Summary for 3H0B
Entry DOI10.2210/pdb3h0b/pdb
DescriptorBeta-secretase 1, 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine (3 entities in total)
Functional Keywordsaspartyl protease, alternative splicing, disulfide bond, glycoprotein, hydrolase, membrane, polymorphism, protease, transmembrane, zymogen
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains3
Total formula weight136875.80
Authors
Allison, T.J. (deposition date: 2009-04-08, release date: 2009-07-07, Last modification date: 2023-09-06)
Primary citationStachel, S.J.,Coburn, C.A.,Rush, D.,Jones, K.L.,Zhu, H.,Rajapakse, H.,Graham, S.L.,Simon, A.,Katharine Holloway, M.,Allison, T.J.,Munshi, S.K.,Espeseth, A.S.,Zuck, P.,Colussi, D.,Wolfe, A.,Pietrak, B.L.,Lai, M.T.,Vacca, J.P.
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.
Bioorg.Med.Chem.Lett., 19:2977-2980, 2009
Cited by
PubMed: 19409780
DOI: 10.1016/j.bmcl.2009.04.033
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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