2OP9
Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus
Summary for 2OP9
Entry DOI | 10.2210/pdb2op9/pdb |
Descriptor | Replicase polyprotein 1ab (pp1ab, ORF1AB) 3C-like proteinase (3CL-PRO, 3CLp), NALPHA-[(BENZYLOXY)CARBONYL]-N-[(1R)-4-HYDROXY-1-METHYL-2-OXOBUTYL]-L-PHENYLALANINAMIDE (3 entities in total) |
Functional Keywords | sars, 3clpro, proteinase, protease, hydrolase |
Biological source | SARS coronavirus |
Total number of polymer chains | 2 |
Total formula weight | 67627.16 |
Authors | Craik, C.S.,Goetz, D.H. (deposition date: 2007-01-27, release date: 2007-07-17, Last modification date: 2023-12-27) |
Primary citation | Goetz, D.H.,Choe, Y.,Hansell, E.,Chen, Y.T.,McDowell, M.,Jonsson, C.B.,Roush, W.R.,McKerrow, J.,Craik, C.S. Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus. Biochemistry, 46:8744-8752, 2007 Cited by PubMed: 17605471DOI: 10.1021/bi0621415 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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