6PIF
| V. cholerae TniQ-Cascade complex, open conformation | Descriptor: | Cas7, type I-F CRISPR-associated protein, TniQ monomer 1, ... | Authors: | Halpin-Healy, T, Klompe, S, Sternberg, S.H. | Deposit date: | 2019-06-26 | Release date: | 2019-10-02 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system. Nature, 577, 2020
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6P8W
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6SYI
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6VAU
| Bare actin filament from a partially cofilin-decorated sample | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Huehn, A.R, Bibeau, J.P, Schramm, A.C, Cao, W, De La Cruz, E.M, Sindelar, C.V. | Deposit date: | 2019-12-17 | Release date: | 2020-01-01 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments. Proc.Natl.Acad.Sci.USA, 117, 2020
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6SSD
| Transaminase with PLP bound | Descriptor: | ForI-PLP, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Naismith, J.H, Gao, S. | Deposit date: | 2019-09-06 | Release date: | 2020-01-15 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis. Chem.Commun.(Camb.), 55, 2019
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6SV5
| Amicoumacin kinase AmiN in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Phosphotransferase enzyme family protein, amicoumacin kinase | Authors: | Bourenkov, G.P, Mokrushina, Y.A, Terekhov, S.S, Smirnov, I.V, Gabibov, A.G, Altman, S. | Deposit date: | 2019-09-17 | Release date: | 2020-07-22 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding. Sci Adv, 6, 2020
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6VGS
| Alpha-ketoisovalerate decarboxylase (KivD) from Lactococcus lactis, thermostable mutant | Descriptor: | Alpha-keto acid decarboxylase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | Authors: | Chan, S, Korman, T.P, Sawaya, M.R, Bowie, J.U. | Deposit date: | 2020-01-08 | Release date: | 2020-08-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Isobutanol production freed from biological limits using synthetic biochemistry. Nat Commun, 11, 2020
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4IJ9
| Bovine PKA C-alpha in complex with 2-[[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-(2-thiophenyl)ethanone | Descriptor: | 2-[[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-(2-thiophenyl)ethanone, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | Authors: | Dreyer, M.K, Schiffer, A. | Deposit date: | 2012-12-21 | Release date: | 2013-05-01 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Accounting for Conformational Variability in Protein-Ligand Docking with NMR-Guided Rescoring J.Am.Chem.Soc., 135, 2013
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3IGD
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6V02
| N-terminal 5 domains of CI-MPR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor | Authors: | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | Deposit date: | 2019-11-18 | Release date: | 2020-09-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor. Commun Biol, 3, 2020
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6SM0
| Venus 66 p-Azido-L-Phenylalanin (azF) variant, dark grown | Descriptor: | Green fluorescent protein, OXYGEN MOLECULE, SULFATE ION, ... | Authors: | Rizkallah, P.J, Al Maslookhi, H.S, Jones, D.D. | Deposit date: | 2019-08-21 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Stalling chromophore synthesis of the fluorescent protein Venus reveals the molecular basis of the final oxidation step. Chem Sci, 12, 2021
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6SMS
| Vegetative Insecticidal Protein 1 (Vip1Ac1) from Bacillus thuringiensis | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, SULFATE ION, ... | Authors: | Rizkallah, P.J, Al-Maslookhi, H.S, Berry, C, Jones, D. | Deposit date: | 2019-08-22 | Release date: | 2021-02-10 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Bacillus thuringiensis insecticidal protein 1Ac, VIP1Ac Not Published
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6V6Q
| Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657 | Descriptor: | Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | Authors: | Lin, C.-C, Wieteska, L, Poncet-Montange, G, Suen, K.M, Arold, S.T, Ahmed, Z, Ladbury, J.E. | Deposit date: | 2019-12-05 | Release date: | 2020-11-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | The combined action of the intracellular regions regulates FGFR2 kinase activity Commun Biol, 6, 2023
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6VAO
| Human cofilin-1 decorated actin filament | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Huehn, A.R, Bibeau, J.P, Schramm, A.C, Cao, W, De La Cruz, E.M, Sindelar, C.V. | Deposit date: | 2019-12-17 | Release date: | 2020-01-08 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VCZ
| Crystal structure of Arabidopsis thaliana S-adenosylmethionine Synthase 2 (AtMAT2) | Descriptor: | 2-METHOXYETHANOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, MAGNESIUM ION, ... | Authors: | Sekula, B, Ruszkowski, M, Dauter, Z. | Deposit date: | 2019-12-23 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | S-adenosylmethionine synthases in plants: Structural characterization of type I and II isoenzymes from Arabidopsis thaliana and Medicago truncatula. Int.J.Biol.Macromol., 151, 2020
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6P0R
| Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor | Descriptor: | (3S)-1-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]-N-[(pyridin-4-yl)methyl]pyrrolidin-3-amine, Histone-lysine N-methyltransferase SUV39H2, UNKNOWN ATOM OR ION, ... | Authors: | Halabelian, L, Dong, A, Zeng, H, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2019-05-17 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor to be published
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6V7L
| The structure of the P212121 crystal form of canavalin at 173 K | Descriptor: | BENZOIC ACID, Canavalin | Authors: | McPherson, A. | Deposit date: | 2019-12-08 | Release date: | 2020-02-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Binding of benzoic acid and anions within the cupin domains of the vicilin protein canavalin from jack bean (Canavalia ensiformis): Crystal structures. Biochem.Biophys.Res.Commun., 524, 2020
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3WB4
| Crystal Structure of beta secetase in complex with 2-amino-3,6-dimethyl-6-(2-phenylethyl)-3,4,5,6-tetrahydropyrimidin-4-one | Descriptor: | (6R)-2-amino-3,6-dimethyl-6-(2-phenylethyl)-5,6-dihydropyrimidin-4(3H)-one, Beta-secretase 1, GLYCEROL, ... | Authors: | Yonezawa, S, Fujiwara, K, Yamamoto, T, Hattori, K, Yamakawa, H, Muto, C, Hosono, M, Tanaka, Y, Nakano, T, Takemoto, H, Arisawa, M, Shuto, S. | Deposit date: | 2013-05-13 | Release date: | 2013-10-02 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Conformational restriction approach to beta-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations Bioorg.Med.Chem., 21, 2013
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6PFL
| Crystal structure of Human HUWE1 WWE domain in complex with ADPR | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION | Authors: | Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | Deposit date: | 2019-06-21 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of Human HUWE1 WWE domain in complex with ADPR to be published
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6VAD
| Fanconi Anemia ID complex | Descriptor: | Fanconi anemia group D2 protein, Fanconi anemia, complementation group I | Authors: | Pavletich, N.P. | Deposit date: | 2019-12-17 | Release date: | 2020-03-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex. Nature, 580, 2020
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4ILU
| Crystal structure of Mycobacterium tuberculosis CarD | Descriptor: | RNA polymerase-binding transcription factor CarD, SULFATE ION | Authors: | Thakur, K.G, Kaur, G. | Deposit date: | 2013-01-01 | Release date: | 2013-10-30 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture. Proteins, 82, 2014
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6T1T
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6VG2
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6PBJ
| The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase with Gly190Pro mutation | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | Authors: | Jiao, W, Fan, Y, Blackmore, N.J, Parker, E.J. | Deposit date: | 2019-06-13 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis . J.Biol.Chem., 295, 2020
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6PJQ
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