6VG2
Crystal structure of the DNA binding domain of human transcription factor FLI1 in complex with 16-mer DNA CAGAGGATGTGGCTTC
Summary for 6VG2
Entry DOI | 10.2210/pdb6vg2/pdb |
Descriptor | Friend leukemia integration 1 transcription factor, DNA (5'-D(*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*C)-3') (3 entities in total) |
Functional Keywords | dna binding, ewing sarcoma, leukemia, oncogenesis, ets-family, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 43792.05 |
Authors | Hou, C.,Tsodikov, O.V. (deposition date: 2020-01-07, release date: 2020-11-25, Last modification date: 2023-10-11) |
Primary citation | Hou, C.,Mandal, A.,Rohr, J.,Tsodikov, O.V. Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29:404-412.e4, 2021 Cited by PubMed: 33275876DOI: 10.1016/j.str.2020.11.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.9 Å) |
Structure validation
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