4BRE
| Legionella pneumophila NTPDase1 crystal form II (closed) in complex with transition state mimic adenosine 5'phosphovanadate | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-PHOSPHOVANADATE, ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE I, ... | Authors: | Zebisch, M, Schaefer, P, Lauble, P, Straeter, N. | Deposit date: | 2013-06-04 | Release date: | 2013-07-17 | Last modified: | 2013-12-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystallographic Snapshots Along the Reaction Pathway of Nucleoside Triphosphate Diphosphohydrolases Structure, 21, 2013
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4BRN
| Legionella pneumophila NTPDase1 crystal form III (closed) in complex with Mg AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE I, ... | Authors: | Zebisch, M, Schaefer, P, Lauble, P, Straeter, N. | Deposit date: | 2013-06-04 | Release date: | 2013-07-17 | Last modified: | 2013-12-25 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Crystallographic Snapshots Along the Reaction Pathway of Nucleoside Triphosphate Diphosphohydrolases Structure, 21, 2013
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6SY2
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2W5P
| DraE Adhesin in complex with Chloramphenicol Succinate (monoclinic form) | Descriptor: | CHLORAMPHENICOL SUCCINATE, DR HEMAGGLUTININ STRUCTURAL SUBUNIT, SULFATE ION | Authors: | Pettigrew, D.M, Roversi, P, Davies, S.G, Russell, A.J, Lea, S.M. | Deposit date: | 2008-12-11 | Release date: | 2009-06-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A Structural Study of the Interaction between the Dr Haemagglutinin Drae and Derivatives of Chloramphenicol Acta Crystallogr.,Sect.D, 65, 2009
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6ZS2
| Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol | Descriptor: | 1,2-ETHANEDIOL, 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol, Transcription activator BRG1 | Authors: | Preuss, F, Joerger, A.C, Kraemer, A, Wanior, M, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2020-07-15 | Release date: | 2020-10-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63, 2020
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2JKJ
| DraE Adhesin in complex with Chloramphenicol Succinate | Descriptor: | CHLORAMPHENICOL, DR HEMAGGLUTININ STRUCTURAL SUBUNIT, SULFATE ION, ... | Authors: | Pettigrew, D.M, Roversi, P, Davies, S.G, Russell, A.J, Lea, S.M. | Deposit date: | 2008-08-28 | Release date: | 2008-12-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Structural Study of the Interaction between the Dr Haemagglutinin Drae and Derivatives of Chloramphenicol Acta Crystallogr.,Sect.D, 65, 2009
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2JKL
| DraE Adhesin in complex with Bromamphenicol | Descriptor: | 1,2-ETHANEDIOL, BROMAMPHENICOL, CHLORAMPHENICOL, ... | Authors: | Pettigrew, D.M, Roversi, P, Davies, S.G, Russell, A.J, Lea, S.M. | Deposit date: | 2008-08-28 | Release date: | 2008-12-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A Structural Study of the Interaction between the Dr Haemagglutinin Drae and Derivatives of Chloramphenicol Acta Crystallogr.,Sect.D, 65, 2009
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2JKN
| DraE Adhesin in complex with Chloramphenicol Succinate (trigonal form) | Descriptor: | 1,2-ETHANEDIOL, CHLORAMPHENICOL SUCCINATE, DR HEMAGGLUTININ STRUCTURAL SUBUNIT, ... | Authors: | Pettigrew, D.M, Roversi, P, Davies, S.G, Russell, A.J, Lea, S.M. | Deposit date: | 2008-08-28 | Release date: | 2008-12-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol. Acta Crystallogr. D Biol. Crystallogr., 65, 2009
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7S4E
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6LTH
| Structure of human BAF Base module | Descriptor: | AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ... | Authors: | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | Deposit date: | 2020-01-22 | Release date: | 2020-02-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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6LTJ
| Structure of nucleosome-bound human BAF complex | Descriptor: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | Authors: | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | Deposit date: | 2020-01-22 | Release date: | 2020-02-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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4QY4
| Crystal structure of the bromodomain of human SMARCA2 | Descriptor: | SMARCA2 protein, ZINC ION | Authors: | Tallant, C, Savitsky, P, Nunez-Alonso, G, Fonseca, M, Krojer, T, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2014-07-23 | Release date: | 2014-08-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Crystal structure of the bromodomain of human SMARCA2 To be Published
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7Z6L
| Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[[2-[3-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Roy, M.J, Bader, G, Farnaby, W, Ciulli, A. | Deposit date: | 2022-03-12 | Release date: | 2022-09-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z77
| Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[(1~{S})-4-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]butyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2022-03-15 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z76
| Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[(1~{R})-2-[(2~{R})-1-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propan-2-yl]oxy-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-1-[(2~{S})-2-[[1-(dimethylamino)cyclopropyl]carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2022-03-15 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z78
| Crystal structure of compound 4 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | 4-bromanyl-7-cyclopentyl-9-piperidin-4-yl-benzimidazolo[1,2-a]quinazolin-5-one, Probable global transcription activator SNF2L2, ZINC ION | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2022-03-15 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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5GJK
| Crystal Structure of BAF47 and BAF155 Complex | Descriptor: | GLYCEROL, PHOSPHATE ION, SWI/SNF complex subunit SMARCC1, ... | Authors: | Yan, L, Qian, C. | Deposit date: | 2016-06-30 | Release date: | 2017-06-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | Structural Insights into BAF47 and BAF155 Complex Formation. J. Mol. Biol., 429, 2017
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4MPQ
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6V45
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8CU5
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5TS3
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5EZ3
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1UV5
| GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME | Descriptor: | 6-BROMOINDIRUBIN-3'-OXIME, CHLORIDE ION, COBALT (II) ION, ... | Authors: | Dajani, R, Pearl, L.H, Roe, S.M. | Deposit date: | 2004-01-14 | Release date: | 2004-01-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Gsk-3-Selective Inhibitors Derived from Tyrian Purple Indurubins Chem.Biol., 10, 2003
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3VAB
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4K3Z
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