7Z78

Crystal structure of compound 4 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Summary for 7Z78

Entry DOI	10.2210/pdb7z78/pdb
Related	7Z6L 7Z76 7Z77
Descriptor	Probable global transcription activator SNF2L2, 4-bromanyl-7-cyclopentyl-9-piperidin-4-yl-benzimidazolo[1,2-a]quinazolin-5-one, ZINC ION, ... (4 entities in total)
Functional Keywords	protac, complex, bromodomain, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	44799.42
Authors	Bader, G.,Boettcher, J.,Wolkerstorfer, B. (deposition date: 2022-03-15, release date: 2022-09-14, Last modification date: 2024-01-31)
Primary citation	Kofink, C.,Trainor, N.,Mair, B.,Wohrle, S.,Wurm, M.,Mischerikow, N.,Roy, M.J.,Bader, G.,Greb, P.,Garavel, G.,Diers, E.,McLennan, R.,Whitworth, C.,Vetma, V.,Rumpel, K.,Scharnweber, M.,Fuchs, J.E.,Gerstberger, T.,Cui, Y.,Gremel, G.,Chetta, P.,Hopf, S.,Budano, N.,Rinnenthal, J.,Gmaschitz, G.,Mayer, M.,Koegl, M.,Ciulli, A.,Weinstabl, H.,Farnaby, W. A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13:5969-5969, 2022 Cited by PubMed: 36216795 DOI: 10.1038/s41467-022-33430-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.32 Å)

Structure validation