7Z77
Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB
Summary for 7Z77
Entry DOI | 10.2210/pdb7z77/pdb |
Related | 7Z6L 7Z76 |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (6 entities in total) |
Functional Keywords | protac, complex, bromodomain, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 56827.93 |
Authors | Bader, G.,Boettcher, J.,Wolkerstorfer, B. (deposition date: 2022-03-15, release date: 2022-09-14, Last modification date: 2024-01-31) |
Primary citation | Kofink, C.,Trainor, N.,Mair, B.,Wohrle, S.,Wurm, M.,Mischerikow, N.,Roy, M.J.,Bader, G.,Greb, P.,Garavel, G.,Diers, E.,McLennan, R.,Whitworth, C.,Vetma, V.,Rumpel, K.,Scharnweber, M.,Fuchs, J.E.,Gerstberger, T.,Cui, Y.,Gremel, G.,Chetta, P.,Hopf, S.,Budano, N.,Rinnenthal, J.,Gmaschitz, G.,Mayer, M.,Koegl, M.,Ciulli, A.,Weinstabl, H.,Farnaby, W. A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13:5969-5969, 2022 Cited by PubMed: 36216795DOI: 10.1038/s41467-022-33430-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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