7Z77

Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0030891	cellular_component	VCB complex
A	0070449	cellular_component	elongin complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006338	biological_process	chromatin remodeling
D	0016586	cellular_component	RSC-type complex

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslgdlekdvml.LchNAqtF

Chain	Residue	Details
D	SER1406-PHE1463

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER1377

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869

Chain	Residue	Details
A	THR84

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