7Z6L

Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Summary for 7Z6L

Entry DOI	10.2210/pdb7z6l/pdb
Descriptor	Probable global transcription activator SNF2L2, von Hippel-Lindau disease tumor suppressor, Elongin-C, ... (6 entities in total)
Functional Keywords	bromodomain, protac complex, e3 ligase, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	56843.93
Authors	Roy, M.J.,Bader, G.,Farnaby, W.,Ciulli, A. (deposition date: 2022-03-12, release date: 2022-09-07, Last modification date: 2024-01-31)
Primary citation	Kofink, C.,Trainor, N.,Mair, B.,Wohrle, S.,Wurm, M.,Mischerikow, N.,Roy, M.J.,Bader, G.,Greb, P.,Garavel, G.,Diers, E.,McLennan, R.,Whitworth, C.,Vetma, V.,Rumpel, K.,Scharnweber, M.,Fuchs, J.E.,Gerstberger, T.,Cui, Y.,Gremel, G.,Chetta, P.,Hopf, S.,Budano, N.,Rinnenthal, J.,Gmaschitz, G.,Mayer, M.,Koegl, M.,Ciulli, A.,Weinstabl, H.,Farnaby, W. A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13:5969-5969, 2022 Cited by PubMed: 36216795 DOI: 10.1038/s41467-022-33430-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation