PDB: 1487 resultsInfo pagesStatus searchChemie searchBIRD

---

7F5S	human delta-METTL18 60S ribosome Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Takahashi, M, Kashiwagi, K, Ito, T. Deposit date: 2021-06-22 Release date: 2022-06-22 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. Elife, 11, 2022
8IYT	Crystal Structure of Serine Palmitoyltransferase complexed with D-methylserine Descriptor: (2~{R})-2-methyl-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]-3-oxidanyl-propanoic acid, 1,2-ETHANEDIOL, Serine palmitoyltransferase Authors: Takahashi, A, Murakami, T, Katayama, A, Miyahara, I, Kamiya, N, Ikushiro, H, Yano, T. Deposit date: 2023-04-06 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of Serine Palmitoyltransferase from Sphingobacterium multivorum To Be Published
8IYP	Crystal structure of serine palmitoyltransferase soaked in 190 mM D-serine solution Descriptor: 1,2-ETHANEDIOL, Serine palmitoyltransferase, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE Authors: Takahashi, A, Murakami, T, Katayama, A, Miyahara, I, Kamiya, N, Ikushiro, H, Yano, T. Deposit date: 2023-04-05 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (1.651 Å) Cite: Crystal structure of Serine Palmitoyltransferase from Sphingobacterium multivorum To Be Published
3KBZ	Crystal structure of human liver FBPase in complex with tricyclic inhibitor 6 Descriptor: Fructose-1,6-bisphosphatase 1, {[(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid Authors: Takahashi, M, Sone, J, Hanzawa, H. Deposit date: 2009-10-20 Release date: 2010-02-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3KC1	Crystal structure of human liver FBPase in complex with tricyclic inhibitor 19a Descriptor: Fructose-1,6-bisphosphatase 1, {[(7-carbamoyl-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid Authors: Takahashi, M, Sone, J, Hanzawa, H. Deposit date: 2009-10-20 Release date: 2010-02-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
6J6Y	FGFR4 D2 - Fab complex Descriptor: Fab Heavy chain, Fab light chain, Fibroblast growth factor receptor 4 Authors: Takahashi, M, Hanzawa, H. Deposit date: 2019-01-16 Release date: 2019-08-07 Last modified: 2019-10-16 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity. Mol.Cancer Ther., 18, 2019
3KC0	Crystal structure of human liver FBPase in complex with tricyclic inhibitor 10b Descriptor: Fructose-1,6-bisphosphatase 1, [(8H-indeno[1,2-d][1,3]thiazol-4-yloxy)methyl]phosphonic acid Authors: Takahashi, M, Sone, J, Hanzawa, H. Deposit date: 2009-10-20 Release date: 2010-02-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
6LUR	Human PUF60 UHM domain (thioredoxin fusion) in complex with a small molecule binder Descriptor: 4-[2-[4-(aminomethyl)phenyl]phenyl]piperazin-2-one, Thioredoxin 1,Poly(U)-binding-splicing factor PUF60 Authors: Takahashi, M, Hanzawa, H. Deposit date: 2020-01-30 Release date: 2020-04-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Revisiting biomolecular NMR spectroscopy for promoting small-molecule drug discovery. J.Biomol.Nmr, 74, 2020
5ETY	Crystal Structure of human Tankyrase-1 bound to K-756 Descriptor: 3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-1,4-dihydroquinazolin-2-one, Tankyrase-1, ZINC ION Authors: Takahashi, Y, Miyagi, H, Suzuki, M, Saito, J. Deposit date: 2015-11-18 Release date: 2016-06-22 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The Discovery and Characterization of K-756, a Novel Wnt/ beta-Catenin Pathway Inhibitor Targeting Tankyrase Mol.Cancer Ther., 15, 2016
2MGZ	Solution structure of RBFOX family ASD-1 RRM and SUP-12 RRM in ternary complex with RNA Descriptor: Protein ASD-1, isoform a, Protein SUP-12, ... Authors: Takahashi, M, Kuwasako, K, Unzai, S, Tsuda, K, Yoshikawa, S, He, F, Kobayashi, N, Guntert, P, Shirouzu, M, Ito, T, Tanaka, A, Yokoyama, S, Hagiwara, M, Kuroyanagi, H, Muto, Y. Deposit date: 2013-11-12 Release date: 2014-08-13 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing Nat.Struct.Mol.Biol., 21, 2014
8G21	Reelin C-Terminal Region Descriptor: Reelin Authors: Chandrahas, A.S, Marino, C, Arboleda-Velasquez, J.F. Deposit date: 2023-02-03 Release date: 2023-05-31 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man. Nat Med, 29, 2023
3W5E	Crystal structure of phosphodiesterase 4B in complex with compound 31e Descriptor: CALCIUM ION, N-tert-butyl-2-{4-[(5,5-dioxido-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl}acetamide, ZINC ION, ... Authors: Takahashi, M, Hanzawa, H. Deposit date: 2013-01-28 Release date: 2013-05-29 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors Bioorg.Med.Chem.Lett., 23, 2013
3WD9	Crystal structure of phosphodiesterase 4B in complex with compound 10f Descriptor: 4-[(4-{2-[(2,2-dimethylpropyl)amino]-2-oxoethyl}phenyl)amino]-2-phenylpyrimidine-5-carboxamide, CALCIUM ION, ZINC ION, ... Authors: Takahashi, M, Hanzawa, H. Deposit date: 2013-06-11 Release date: 2013-10-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors Bioorg.Med.Chem., 21, 2013
8T8A	Structure of arginine oxidase from Pseudomonas sp. TRU 7192 Descriptor: Amine oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE Authors: Takahashi, K, Yamaguchi, H, Tatsumi, M, Sugiki, M. Deposit date: 2023-06-22 Release date: 2024-06-26 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structural basis of arginine oxidase from Pseudomonas sp. TRU 7192 To Be Published
2RU3	Solution structure of c.elegans SUP-12 RRM in complex with RNA Descriptor: Protein SUP-12, isoform a, RNA (5'-R(*GP*UP*GP*UP*GP*C)-3') Authors: Takahashi, M, Kuwasako, K, Unzai, S, Tsuda, K, Yoshikawa, S, He, F, Kobayashi, N, Guntert, P, Shirouzu, M, Ito, T, Tanaka, A, Yokoyama, S, Hagiwara, M, Kuroyanagi, H, Muto, Y. Deposit date: 2013-11-12 Release date: 2014-08-13 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing Nat.Struct.Mol.Biol., 21, 2014
3A29	Crystal structure of human liver FBPase in complex with tricyclic inhibitor Descriptor: 2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl dihydrogen phosphate, Fructose-1,6-bisphosphatase 1 Authors: Takahashi, M, Sone, J, Hanzawa, H. Deposit date: 2009-05-08 Release date: 2009-10-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors Bioorg.Med.Chem.Lett., 19, 2009
2RNE	Solution structure of the second RNA recognition motif (RRM) of TIA-1 Descriptor: Tia1 protein Authors: Takahashi, M, Kuwasako, K, Abe, C, Tsuda, K, Inoue, M, Terada, T, Shirouzu, M, Kobayashi, N, Kigawa, T, Taguchi, S, Guntert, P, Hayashizaki, Y, Tanaka, A, Muto, Y, Yokoyama, S. Deposit date: 2007-12-19 Release date: 2008-11-04 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode Biochemistry, 47, 2008
8GZC	Crystal structure of EP300 HAT domain in complex with compound 10 Descriptor: (2~{R},4~{R})-4-fluoranyl-1-[1-(4-methoxyphenyl)cyclohexyl]carbonyl-~{N}-(1~{H}-pyrazolo[4,3-b]pyridin-5-yl)pyrrolidine-2-carboxamide, Histone acetyltransferase p300, ZINC ION Authors: Takahashi, M, Hanzawa, H. Deposit date: 2022-09-26 Release date: 2023-01-11 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor. J.Med.Chem., 66, 2023
8HVA	Crystal structure of EGFR_TMX in complex with covalently bound compound 14 Descriptor: Epidermal growth factor receptor, ~{N}-[6-(1-methylindol-3-yl)pyrimidin-4-yl]prop-2-enamide Authors: Takahashi, M, Dokurno, P. Deposit date: 2022-12-26 Release date: 2023-12-13 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.77 Å) Cite: A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase. Rsc Med Chem, 14, 2023
8H1W	Serine Palmitoyltransferase from Sphingobacterium multivorum Descriptor: 1,2-ETHANEDIOL, Serine palmitoyltransferase Authors: Takahashi, A, Murakami, T, Katayama, A, Miyahara, I, Kamiya, N, Ikushiro, H, Yano, T. Deposit date: 2022-10-04 Release date: 2023-08-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structural insights into the substrate recognition of serine palmitoyltransferase from Sphingobacterium multivorum. J.Biol.Chem., 299, 2023
5AVF	The ligand binding domain of Mlp37 with taurine Descriptor: 2-AMINOETHANESULFONIC ACID, Methyl-accepting chemotaxis (MCP) signaling domain protein Authors: Takahashi, Y, Sumita, K, Uchida, Y, Nishiyama, S, Kawagishi, I, Imada, K. Deposit date: 2015-06-15 Release date: 2016-06-01 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants Sci Rep, 6, 2016
5AVE	The ligand binding domain of Mlp37 with serine Descriptor: Methyl-accepting chemotaxis (MCP) signaling domain protein, SERINE Authors: Takahashi, Y, Sumita, K, Uchida, Y, Nishiyama, S, Kawagishi, I, Imada, K. Deposit date: 2015-06-15 Release date: 2016-03-02 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants Sci Rep, 6, 2016
7VHZ	Crystal structure of EP300 HAT domain in complex with compound 7 Descriptor: (2R)-N-(2H-indazol-4-yl)-1-[1-(4-methoxyphenyl)cyclopentyl]carbonyl-pyrrolidine-2-carboxamide, Histone acetyltransferase p300, ZINC ION Authors: Takahashi, M, Hanzawa, H. Deposit date: 2021-09-24 Release date: 2022-04-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg.Med.Chem.Lett., 66, 2022
7VHY	Crystal structure of EP300 HAT domain in complex with compound (+)-3 Descriptor: Histone acetyltransferase p300, ZINC ION, [(6R)-6-(1H-indazol-4-ylmethyl)-1,4-oxazepan-4-yl]-[1-(4-methoxyphenyl)cyclopentyl]methanone Authors: Takahashi, M, Hanzawa, H. Deposit date: 2021-09-24 Release date: 2022-04-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg.Med.Chem.Lett., 66, 2022
7VI0	Crystal structure of EP300 HAT domain in complex with compound 11 Descriptor: (4S)-N-(3H-indazol-4-yl)-3-[1-(4-methoxyphenyl)cyclopentyl]carbonyl-1,1-bis(oxidanylidene)-1,3-thiazolidine-4-carboxamide, Histone acetyltransferase p300, ZINC ION Authors: Takahashi, M, Hanzawa, H. Deposit date: 2021-09-24 Release date: 2022-04-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg.Med.Chem.Lett., 66, 2022

<12345678910111213141516>