PDB: 8880 resultsInfo pagesStatus searchChemie searchBIRD

---

5ZAL	Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate Descriptor: Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) Authors: Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. Deposit date: 2018-02-07 Release date: 2018-05-09 Last modified: 2020-08-05 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173, 2018
6V53	The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000985494 Descriptor: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... Authors: Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. Deposit date: 2019-12-03 Release date: 2020-12-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000985494 To Be Published
6YJ6	Structure of the TFIIIC subcomplex tauA Descriptor: Transcription factor tau 131 kDa subunit, Transcription factor tau 55 kDa subunit, Transcription factor tau 95 kDa subunit,Transcription factor tau 95 kDa subunit Authors: Vorlaender, M.K, Muller, C.W. Deposit date: 2020-04-02 Release date: 2020-09-16 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structure of the TFIIIC subcomplex tau A provides insights into RNA polymerase III pre-initiation complex formation. Nat Commun, 11, 2020
2BPC	CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM Descriptor: DNA POLYMERASE BETA, MANGANESE (II) ION Authors: Sawaya, M.R, Pelletier, H, Kumar, A, Wilson, S.H, Kraut, J. Deposit date: 1994-07-08 Release date: 1994-08-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Science, 264, 1994
6VLL	The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with SJ000986213 Descriptor: MANGANESE (II) ION, Polymerase acidic protein, SULFATE ION, ... Authors: Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. Deposit date: 2020-01-24 Release date: 2021-02-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.87 Å) Cite: The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986213 To Be Published
3MAQ	Crystal structure of E.coli Pol II-normal DNA-dGTP ternary complex Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*AP*CP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), ... Authors: Yang, W, Wang, F. Deposit date: 2010-03-24 Release date: 2010-04-07 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insight into translesion synthesis by DNA Pol II Cell(Cambridge,Mass.), 139, 2009
5ZC9	Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex Descriptor: (1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ... Authors: Iwasaki, W, Takahashi, M, Sakamoto, A, Iwasaki, S, Ito, T. Deposit date: 2018-02-16 Release date: 2019-01-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA. Mol. Cell, 73, 2019
7ML8	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ001023038 Descriptor: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-phenyl-1,6-dihydropyrimidine-4-carboxamide, GLUTAMIC ACID, Hexa Vinylpyrrolidone K15, ... Authors: Cuypers, M.G, Slavish, P.J, Yun, M.K, Dubois, R, Rankovic, Z, White, S.W. Deposit date: 2021-04-27 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with St Jude compound AC067-19 To Be Published
6Q5Y	Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser5 Descriptor: PHD finger protein 3, pSer2pSer5 Authors: Grishkovskaya, I, Djinovic-Carugo, K, Slade, D. Deposit date: 2018-12-09 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.85 Å) Cite: PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC Nat Commun, 12, 2021
7MX0	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988558 Descriptor: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2021-05-17 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.48 Å) Cite: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988558 To Be Published
1UON	REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION Descriptor: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 5'-R(*GP*GP*GP*GP*GP*)-3', 5'-R(*UP*AP*GP*CP*CP*CP*CP*CP*)-3', ... Authors: Zhang, X, Walker, S.B, Chipman, P.R, Nibert, M.L, Baker, T.S. Deposit date: 2003-09-21 Release date: 2003-11-13 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (7.6 Å) Cite: Reovirus Polymerase Lambda3 Localized by Cryo-Electron Microscopy of Virions at a Resolution of 7.6 A Nat.Struct.Biol., 10, 2003
2Q66	Structure of Yeast Poly(A) Polymerase with ATP and oligo(A) Descriptor: 1,2-ETHANEDIOL, 5'-R(P*AP*AP*AP*AP*A)-3', ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Bohm, A, Balbo, P. Deposit date: 2007-06-04 Release date: 2007-08-28 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis. Structure, 15, 2007
6EUV	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787) Descriptor: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2 Authors: Cusack, S, Lethier, M. Deposit date: 2017-10-31 Release date: 2017-12-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
8FYH	G4 RNA-mediated PRC2 dimer Descriptor: G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... Authors: Song, J, Kasinath, V. Deposit date: 2023-01-26 Release date: 2023-10-04 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 2023
5FDD	Endonuclease inhibitor 1 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 Descriptor: 5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde, MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein, ... Authors: Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Hoshino, T. Deposit date: 2015-12-16 Release date: 2015-12-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.506 Å) Cite: Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit Biochemistry, 55, 2016
5FDG	Endonuclease inhibitor 3 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 Descriptor: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, Polymerase acidic protein, ... Authors: Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Hoshino, T. Deposit date: 2015-12-16 Release date: 2015-12-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit Biochemistry, 55, 2016
7MY5	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988503 Descriptor: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2021-05-20 Release date: 2022-05-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.38 Å) Cite: The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988503 To Be Published
5OMF	Closed, ternary structure of KOD DNA polymerase Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), ... Authors: Kropp, H.M, Betz, K, Wirth, J, Diederichs, K, Marx, A. Deposit date: 2017-07-31 Release date: 2017-12-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.092 Å) Cite: Crystal structures of ternary complexes of archaeal B-family DNA polymerases. PLoS ONE, 12, 2017
5I13	Endonuclease inhibitor 2 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 Descriptor: 4-{(E)-[2-(4-chlorophenyl)hydrazinylidene]methyl}benzene-1,2,3-triol, MANGANESE (II) ION, Polymerase acidic protein, ... Authors: Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Hoshino, T. Deposit date: 2016-02-05 Release date: 2016-02-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.151 Å) Cite: Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit Biochemistry, 55, 2016
2W69	Influenza polymerase fragment Descriptor: MANGANESE (II) ION, POLYMERASE ACIDIC PROTEIN, SULFATE ION Authors: Dias, A, Bouvier, D, Crepin, T, McCarthy, A.A, Hart, D.J, Baudin, F, Cusack, S, Ruigrok, R.W.H. Deposit date: 2008-12-17 Release date: 2009-02-03 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The CAP-Snatching Endonuclease of Influenza Virus Polymerase Resides in the Pa Subunit Nature, 458, 2009
4AWK	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1 Descriptor: (2Z)-4-[(3S)-1-(benzylsulfonyl)-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-04 Release date: 2012-08-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
7K77	The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ001008025 Descriptor: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. Deposit date: 2020-09-22 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.78 Å) Cite: The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ001008025 To Be Published
4AWM	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with (-)-epigallocatechin gallate from green tea Descriptor: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, MANGANESE (II) ION, POLYMERASE PA Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-04 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
7KNR	The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988558 Descriptor: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, P.J, Jayaraman, S, White, S.W. Deposit date: 2020-11-05 Release date: 2021-11-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.48 Å) Cite: The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988558 To Be Published
7KNY	The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988528 Descriptor: 2-(2-fluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, P.J, Jayaraman, S, White, S.W. Deposit date: 2020-11-06 Release date: 2021-11-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.48 Å) Cite: The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988528 To Be Published

<41424344454647484950515253545556>