8PW8
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![BU of 8pw8 by Molmil](/molmil-images/mine/8pw8) | Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA2) | Descriptor: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A. | Deposit date: | 2023-07-19 | Release date: | 2023-11-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12, 2024
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8PWA
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![BU of 8pwa by Molmil](/molmil-images/mine/8pwa) | Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA4) | Descriptor: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7~{H}-purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid, ACETATE ION, MAGNESIUM ION, ... | Authors: | Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A. | Deposit date: | 2023-07-19 | Release date: | 2023-11-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12, 2024
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8PWB
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![BU of 8pwb by Molmil](/molmil-images/mine/8pwb) | Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA6) | Descriptor: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(7~{H}-purin-6-ylcarbamoyl)amino]-2-azanyl-butanoic acid, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A. | Deposit date: | 2023-07-19 | Release date: | 2023-11-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12, 2024
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8PW9
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![BU of 8pw9 by Molmil](/molmil-images/mine/8pw9) | Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA1) | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[2-[[9-[(2~{R},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethylamino]methyl]oxolane-3,4-diol, ACETATE ION, MAGNESIUM ION, ... | Authors: | Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A. | Deposit date: | 2023-07-19 | Release date: | 2023-11-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12, 2024
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4NFO
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![BU of 4nfo by Molmil](/molmil-images/mine/4nfo) | Crystal Structure Analysis of the 16mer GCAGACUUAAGUCUGC | Descriptor: | GCAGACUUAAGUCUGC, SPERMINE | Authors: | Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y. | Deposit date: | 2013-10-31 | Release date: | 2014-07-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA. Acs Chem.Biol., 9, 2014
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4NFP
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![BU of 4nfp by Molmil](/molmil-images/mine/4nfp) | Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 8-aza-7-deaza-7-ethynyl Adenosine | Descriptor: | FORMAMIDE, GCAG(A7E)CUUAAGUCUGC | Authors: | Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y. | Deposit date: | 2013-10-31 | Release date: | 2014-07-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA. Acs Chem.Biol., 9, 2014
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4NFQ
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![BU of 4nfq by Molmil](/molmil-images/mine/4nfq) | Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 7-triazolyl-8-aza-7-deazaadenosine | Descriptor: | GCAG(7AT)CUUAAGUCUGC | Authors: | Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y. | Deposit date: | 2013-10-31 | Release date: | 2014-07-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA. Acs Chem.Biol., 9, 2014
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2E48
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![BU of 2e48 by Molmil](/molmil-images/mine/2e48) | Crystal Structure of Human D-Amino Acid Oxidase: Substrate-Free Holoenzyme | Descriptor: | D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Kawazoe, T, Tsuge, H, Imagawa, T, Fukui, K. | Deposit date: | 2006-12-05 | Release date: | 2007-03-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of d-DOPA oxidation by d-amino acid oxidase: Alternative pathway for dopamine biosynthesis. Biochem.Biophys.Res.Commun., 355, 2007
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2E82
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![BU of 2e82 by Molmil](/molmil-images/mine/2e82) | Crystal structure of human D-amino acid oxidase complexed with imino-DOPA | Descriptor: | (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Kawazoe, T, Tsuge, H, Imagawa, T, Kuramitsu, S, Fukui, K. | Deposit date: | 2007-01-16 | Release date: | 2007-03-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of d-DOPA oxidation by d-amino acid oxidase: Alternative pathway for dopamine biosynthesis. Biochem.Biophys.Res.Commun., 355, 2007
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2E4A
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![BU of 2e4a by Molmil](/molmil-images/mine/2e4a) | Crystal Structure of Human D-Amino Acid Oxidase in complex with o-aminobenzoate | Descriptor: | 2-AMINOBENZOIC ACID, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Kawazoe, T, Tsuge, H, Imagawa, T, Fukui, K. | Deposit date: | 2006-12-05 | Release date: | 2007-03-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of d-DOPA oxidation by d-amino acid oxidase: Alternative pathway for dopamine biosynthesis. Biochem.Biophys.Res.Commun., 355, 2007
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2E49
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![BU of 2e49 by Molmil](/molmil-images/mine/2e49) | Crystal Structure of Human D-Amino Acid Oxidase in Complex with Imino-Serine | Descriptor: | 3-hydroxy-2-iminopropanoic acid, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Kawazoe, T, Tsuge, H, Imagawa, T, Fukui, K. | Deposit date: | 2006-12-05 | Release date: | 2007-03-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of d-DOPA oxidation by d-amino acid oxidase: Alternative pathway for dopamine biosynthesis. Biochem.Biophys.Res.Commun., 355, 2007
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1S39
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![BU of 1s39 by Molmil](/molmil-images/mine/1s39) | CRYSTAL STRUCTURE OF TGT IN COMPLEX WITH 2-aminoquinazolin-4(3H)-one | Descriptor: | 2-AMINOQUINAZOLIN-4(3H)-ONE, ZINC ION, tRNA guanine transglycosylase | Authors: | Brenk, R, Meyer, E.A, Reuter, K, Garcia, G.A, Stubbs, M.T, Klebe, G. | Deposit date: | 2004-01-12 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Synthesis and In Vitro Evaluation of 2-Aminoquinazolin-4(3H)-one-Based Inhibitors for tRNA-Guanine Transglycosylase (TGT) HELV.CHIM.ACTA, 87, 2004
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2Z7J
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![BU of 2z7j by Molmil](/molmil-images/mine/2z7j) | Structural insights into de multifunctional VP3 protein of birnaviruses:gold derivative | Descriptor: | Capsid assembly protein VP3, GOLD ION | Authors: | Casanas, A, Navarro, A, Ferrer-Orta, C, Gonzalez, D, Rodriguez, J.F, Verdaguer, N. | Deposit date: | 2007-08-23 | Release date: | 2008-02-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into the multifunctional protein VP3 of birnaviruses. Structure, 16, 2008
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3GO5
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![BU of 3go5 by Molmil](/molmil-images/mine/3go5) | |
3UNG
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![BU of 3ung by Molmil](/molmil-images/mine/3ung) | Structure of the Cmr2 subunit of the CRISPR RNA silencing complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Cmr2dHD, ... | Authors: | Cocozaki, A.I, Ramia, N.F, Shao, Y, Hale, C.R, Terns, R.M, Terns, M.P, Li, H. | Deposit date: | 2011-11-15 | Release date: | 2012-03-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structure of the Cmr2 Subunit of the CRISPR-Cas RNA Silencing Complex. Structure, 20, 2012
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3UR3
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![BU of 3ur3 by Molmil](/molmil-images/mine/3ur3) | Structure of the Cmr2 subunit of the CRISPR RNA silencing complex | Descriptor: | CALCIUM ION, Cmr2dHD, ZINC ION | Authors: | Cocozaki, A.I, Ramia, N.F, Shao, Y, Hale, C.R, Terns, R.M, Terns, M.P, Li, H. | Deposit date: | 2011-11-21 | Release date: | 2012-03-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.405 Å) | Cite: | Structure of the Cmr2 Subunit of the CRISPR-Cas RNA Silencing Complex. Structure, 20, 2012
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1U09
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![BU of 1u09 by Molmil](/molmil-images/mine/1u09) | Footand Mouth Disease Virus RNA-dependent RNA polymerase | Descriptor: | polyprotein | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2004-07-13 | Release date: | 2004-08-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA J.Biol.Chem., 279, 2004
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7EJO
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![BU of 7ejo by Molmil](/molmil-images/mine/7ejo) | Structure of ERH-2 bound to TOST-1 | Descriptor: | Enhancer of rudimentary homolog 2, Enhancer of rudimentary homolog 2,Protein tost-1 | Authors: | Wang, X, Xu, C. | Deposit date: | 2021-04-02 | Release date: | 2021-08-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.191 Å) | Cite: | Molecular basis for PICS-mediated piRNA biogenesis and cell division. Nat Commun, 12, 2021
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4J3C
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![BU of 4j3c by Molmil](/molmil-images/mine/4j3c) | Crystal structure of 16S ribosomal RNA methyltransferase RsmE | Descriptor: | Ribosomal RNA small subunit methyltransferase E | Authors: | Eswaramoorthy, S, Chamala, S, Evans, B, Foti, F, Gizzi, A, Hillerich, B, Kar, A, Lafleur, J, Seidel, R, Villigas, G, Zencheck, W, Al Obaidi, N, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-02-05 | Release date: | 2013-02-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of 16S ribosomal RNA methyltransferase RsmE TO BE PUBLISHED
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6ZXV
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![BU of 6zxv by Molmil](/molmil-images/mine/6zxv) | |
6ZXY
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![BU of 6zxy by Molmil](/molmil-images/mine/6zxy) | |
4CTG
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![BU of 4ctg by Molmil](/molmil-images/mine/4ctg) | The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle | Descriptor: | P1 | Authors: | Bakker, S.E, Groppelli, E, Pearson, A.R, Stockley, P.G, Rowlands, D.J, Ranson, N.A. | Deposit date: | 2014-03-13 | Release date: | 2014-05-21 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (17 Å) | Cite: | Limits of Structural Plasticity in a Picornavirus Capsid Revealed by a Massively Expanded Equine Rhinitis a Virus Particle. J.Virol., 88, 2014
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4CTF
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![BU of 4ctf by Molmil](/molmil-images/mine/4ctf) | The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle | Descriptor: | EQUINE RHINITIS A VIRUS, P1, VP1 | Authors: | Bakker, S.E, Groppelli, E, Pearson, A.R, Stockley, P.G, Rowlands, D.J, Ranson, N.A. | Deposit date: | 2014-03-13 | Release date: | 2014-05-21 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (17 Å) | Cite: | Limits of Structural Plasticity in a Picornavirus Capsid Revealed by a Massively Expanded Equine Rhinitis a Virus Particle. J.Virol., 88, 2014
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3M0E
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![BU of 3m0e by Molmil](/molmil-images/mine/3m0e) | Crystal structure of the ATP-bound state of Walker B mutant of NtrC1 ATPase domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Transcriptional regulator (NtrC family) | Authors: | Chen, B, Sysoeva, T.A, Chowdhury, S, Rusu, M, Birmanns, S, Guo, L, Hanson, J, Yang, H, Nixon, B.T. | Deposit date: | 2010-03-02 | Release date: | 2010-11-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase for Remodeling Bacterial RNA Polymerase. Structure, 18, 2010
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4NJ4
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![BU of 4nj4 by Molmil](/molmil-images/mine/4nj4) | Crystal Structure of Human ALKBH5 | Descriptor: | GLYCEROL, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... | Authors: | Aik, W.S, McDonough, M.A, Schofield, C.J. | Deposit date: | 2013-11-08 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res., 42, 2014
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