8PW8
Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA2)
Summary for 8PW8
Entry DOI | 10.2210/pdb8pw8/pdb |
Descriptor | N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid, ... (5 entities in total) |
Functional Keywords | mettl3, bisubstrate, complex, m6a, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 60284.63 |
Authors | Bedi, R.K.,Etheve-Quelquejeu, M.,Caflisch, A. (deposition date: 2023-07-19, release date: 2023-11-08, Last modification date: 2024-03-27) |
Primary citation | Corbeski, I.,Vargas-Rosales, P.A.,Bedi, R.K.,Deng, J.,Coelho, D.,Braud, E.,Iannazzo, L.,Li, Y.,Huang, D.,Etheve-Quelquejeu, M.,Cui, Q.,Caflisch, A. The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12:-, 2024 Cited by PubMed: 38470714DOI: 10.7554/eLife.92537 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report