8PW8
Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N6-adenosine-methyltransferase catalytic subunit | polymer | 228 | 26017.8 | 1 | UniProt (Q86U44) Pfam (PF05063) UniProt (by SIFTS) (Q9HCE5) | Homo sapiens (human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B (B) | N6-adenosine-methyltransferase non-catalytic subunit | polymer | 290 | 33547.1 | 1 | UniProt (A4IFD8) Pfam (PF05063) UniProt (by SIFTS) (Q9HCE5) | Homo sapiens (human) | Methyltransferase-like protein 14 |
| 3 | C (A) | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid | non-polymer | 660.6 | 1 | Chemie (HZ2) | |||
| 4 | D (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 354 - 580 (UniProt: Q86U44)
B: 107 - 395 (UniProt: A4IFD8)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59564.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 719.7 | |
| All* | Total formula weight | 60284.6 |
