4NJ4

Crystal Structure of Human ALKBH5

Summary for 4NJ4

Entry DOI	10.2210/pdb4nj4/pdb
Descriptor	RNA demethylase ALKBH5, MANGANESE (II) ION, NITRATE ION, ... (6 entities in total)
Functional Keywords	double-stranded beta helix, jelly-roll motif, dioxygenase, rna demethylase, rna, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus speckle: Q6P6C2
Total number of polymer chains	2
Total formula weight	58630.85
Authors	Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2013-11-08, release date: 2014-01-15, Last modification date: 2023-09-20)
Primary citation	Aik, W.,Scotti, J.S.,Choi, H.,Gong, L.,Demetriades, M.,Schofield, C.J.,McDonough, M.A. Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res., 42:4741-4754, 2014 Cited by PubMed: 24489119 DOI: 10.1093/nar/gku085 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation