4NJ4
Crystal Structure of Human ALKBH5
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 301 |
| Chain | Residue |
| A | HIS204 |
| A | ASP206 |
| A | HIS266 |
| A | HOH405 |
| A | HOH416 |
| A | HOH439 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 302 |
| Chain | Residue |
| A | HOH478 |
| A | HOH542 |
| A | SER217 |
| A | ILE268 |
| A | ARG277 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | GLU212 |
| A | ARG286 |
| A | LEU287 |
| A | ASP288 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 304 |
| Chain | Residue |
| A | ILE201 |
| A | VAL202 |
| A | HIS204 |
| A | UN9305 |
| A | HOH532 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE UN9 A 305 |
| Chain | Residue |
| A | ARG130 |
| A | CYS200 |
| A | ILE201 |
| A | VAL202 |
| A | GLN233 |
| A | GOL304 |
| B | CYS200 |
| B | UN9305 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 301 |
| Chain | Residue |
| B | HIS204 |
| B | ASP206 |
| B | HIS266 |
| B | HOH422 |
| B | HOH431 |
| B | HOH434 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 B 302 |
| Chain | Residue |
| B | SER217 |
| B | ILE268 |
| B | ARG277 |
| B | HOH479 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 303 |
| Chain | Residue |
| A | GLN271 |
| A | HOH428 |
| B | LYS235 |
| B | PRO236 |
| B | ILE237 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 304 |
| Chain | Residue |
| A | ARG93 |
| B | GLU166 |
| B | GLU184 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE UN9 B 305 |
| Chain | Residue |
| A | CYS200 |
| A | UN9305 |
| B | ARG130 |
| B | CYS200 |
| B | ILE201 |
| B | VAL202 |
| B | GLN233 |
| B | HOH480 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24778178","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WKV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24616105","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24778178","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7V4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WL0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"source":"PubMed","id":"34048572","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"37369679","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"34048572","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
