4NJ4

Crystal Structure of Human ALKBH5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	RNA demethylase ALKBH5	polymer	250	28748.7	2	UniProt (Q6P6C2) Pfam (PF13532) In PDB	Homo sapiens (human)	Alkylated DNA repair protein alkB homolog 5, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
2	A, B	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	A, B	NITRATE ION	non-polymer		62.0	3	Chemie (NO3)
4	A, B	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5	A, B	N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE	non-polymer		280.7	2	Chemie (UN9)
6		water	water		18.0	223	Chemie (HOH)

Sequence modifications

A, B: 66 - 292 (UniProt: Q6P6C2)

PDB	External Database	Details
Met 43	-	initiating methionine
His 44	-	expression tag
His 45	-	expression tag
His 46	-	expression tag
His 47	-	expression tag
His 48	-	expression tag
His 49	-	expression tag
Ser 50	-	expression tag
Ser 51	-	expression tag
Gly 52	-	expression tag
Val 53	-	expression tag
Asp 54	-	expression tag
Leu 55	-	expression tag
Gly 56	-	expression tag
Thr 57	-	expression tag
Glu 58	-	expression tag
Asn 59	-	expression tag
Leu 60	-	expression tag
Tyr 61	-	expression tag
Phe 62	-	expression tag
Gln 63	-	expression tag
Ser 64	-	expression tag
Met 65	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57497.4
Non-Polymers*	Number of molecules	10
	Total formula weight	1133.5
All*	Total formula weight	58630.9

*Water molecules are not included.