4NJ4
Crystal Structure of Human ALKBH5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA demethylase ALKBH5 | polymer | 250 | 28748.7 | 2 | UniProt (Q6P6C2) Pfam (PF13532) | Homo sapiens (human) | Alkylated DNA repair protein alkB homolog 5, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 |
| 2 | C, H (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 3 | D, I, J (A, B) | NITRATE ION | non-polymer | 62.0 | 3 | Chemie (NO3) | |||
| 4 | E, F, K (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | G, L (A, B) | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE | non-polymer | 280.7 | 2 | Chemie (UN9) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A, B: 66 - 292 (UniProt: Q6P6C2)
| PDB | External Database | Details |
|---|---|---|
| Met 43 | - | initiating methionine |
| His 44 | - | expression tag |
| His 45 | - | expression tag |
| His 46 | - | expression tag |
| His 47 | - | expression tag |
| His 48 | - | expression tag |
| His 49 | - | expression tag |
| Ser 50 | - | expression tag |
| Ser 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Val 53 | - | expression tag |
| Asp 54 | - | expression tag |
| Leu 55 | - | expression tag |
| Gly 56 | - | expression tag |
| Thr 57 | - | expression tag |
| Glu 58 | - | expression tag |
| Asn 59 | - | expression tag |
| Leu 60 | - | expression tag |
| Tyr 61 | - | expression tag |
| Phe 62 | - | expression tag |
| Gln 63 | - | expression tag |
| Ser 64 | - | expression tag |
| Met 65 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57497.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1133.5 | |
| All* | Total formula weight | 58630.9 |
