PDB: 1372 resultsInfo pagesStatus searchChemie searchBIRD

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5C4G	Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the inhibitor BQR695 in complex with GDP loaded Rab11 Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, N~2~-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]-N-methylglycinamide, ... Authors: Burke, J.E, Fowler, M.L. Deposit date: 2015-06-18 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11. Protein Sci., 25, 2016
5CLL	Truncated Ran wild type in complex with GDP-BeF and RanBD1 Descriptor: BERYLLIUM TRIFLUORIDE ION, E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, ... Authors: Vetter, I.R, Brucker, S. Deposit date: 2015-07-16 Release date: 2015-09-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy. J.Biol.Chem., 290, 2015
5CM8	Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral Descriptor: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a Authors: Popovic, M, Schouten, A, Rehmann, H. Deposit date: 2015-07-16 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J.Struct.Biol., 193, 2016
2H7V	Co-crystal structure of YpkA-Rac1 Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Migration-inducing protein 5, ... Authors: Prehna, G, Ivanov, M, Bliska, J.B, Stebbins, C.E. Deposit date: 2006-06-04 Release date: 2006-09-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Yersinia virulence depends on mimicry of host rho-family nucleotide dissociation inhibitors. Cell(Cambridge,Mass.), 126, 2006
5CM9	Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral Descriptor: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a Authors: Popovic, M, Schouten, A, Rehmann, H. Deposit date: 2015-07-16 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J.Struct.Biol., 193, 2016
6XJS	Crystal Structure of KPT-330 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M, Chook, Y.M. Deposit date: 2020-06-24 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.942 Å) Cite: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
5DHF	Crystal Structure of hRio2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.285 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIS	Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214 Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Monecke, T, Port, S.A, Dickmanns, A, Kehlenbach, R.H, Ficner, R. Deposit date: 2015-09-01 Release date: 2015-11-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep, 13, 2015
6XI7	Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form I) Descriptor: CHLORIDE ION, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... Authors: Chan, A.H, Tran, T.H, Dharmaiah, S, Simanshu, D.K. Deposit date: 2020-06-19 Release date: 2021-01-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
6ZAY	Crystal structure of Atg16L in complex with GDP-bound Rab33B Descriptor: 1,2-ETHANEDIOL, Autophagy-related protein 16-1, DI(HYDROXYETHYL)ETHER, ... Authors: Pantoom, S, Wu, Y.W. Deposit date: 2020-06-06 Release date: 2020-09-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.4 Å) Cite: RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein. Autophagy, 17, 2021
5DH9	Crystal Structure of PKI NES Flip Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (PKINES-Flip3 mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
6XHA	Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF Descriptor: CHLORIDE ION, GLYCEROL, Isoform 2B of GTPase KRas, ... Authors: Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. Deposit date: 2020-06-18 Release date: 2021-01-13 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.87 Å) Cite: KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
6XGV	Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF Descriptor: CHLORIDE ION, GLYCEROL, GTPase KRas, ... Authors: Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. Deposit date: 2020-06-18 Release date: 2021-01-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.11 Å) Cite: KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
6XHB	Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II) Descriptor: CHLORIDE ION, GLYCEROL, GTPase KRas, ... Authors: Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. Deposit date: 2020-06-18 Release date: 2021-01-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
6YX5	Structure of DrrA from Legionella pneumophilia in complex with human Rab8a Descriptor: MAGNESIUM ION, Multifunctional virulence effector protein DrrA, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Schneider, S, Du, J, von Wrisberg, M.K, Lang, K, Itzen, A. Deposit date: 2020-04-30 Release date: 2020-12-23 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1. Nat Commun, 12, 2021
5DHA	Crystal Structure of CPEB4 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (CPEB4 NES reverse mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIF	Crystal Structure of CPEB4 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Cytoplasmic polyadenylation element-binding protein 4, Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.092 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DI9	Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
6XJP	Crystal Structure of KPT-185 bound to CRM1 (537-DLTVK-541 to GLCEQ) Descriptor: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... Authors: Baumhardt, J.M, Chook, Y.M. Deposit date: 2020-06-24 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.802 Å) Cite: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6XJT	Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ) Descriptor: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M, Chook, Y.M. Deposit date: 2020-06-24 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.406 Å) Cite: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
2HV8	Crystal structure of GTP-bound Rab11 in complex with FIP3 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Eathiraj, S, Mishra, A, Prekeris, R, Lambright, D.G. Deposit date: 2006-07-27 Release date: 2006-11-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structural Basis for Rab11-mediated Recruitment of FIP3 to Recycling Endosomes. J.Mol.Biol., 364, 2006
2G77	Crystal Structure of Gyp1 TBC domain in complex with Rab33 GTPase bound to GDP and AlF3 Descriptor: ALUMINUM FLUORIDE, GTPase-activating protein GYP1, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Pan, X, Eathiraj, S, Munson, M, Lambright, D.G. Deposit date: 2006-02-27 Release date: 2006-07-25 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.26 Å) Cite: TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature, 442, 2006
6ZQT	Crystal structure of the RLIP76 Ral binding domain mutant (E427H/Q433L/K440R) in complex with RalB-GMPPNP Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Hurd, C, Brear, P, Revell, J, Ross, S, Mott, H, Owen, D. Deposit date: 2020-07-10 Release date: 2020-11-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases. J.Biol.Chem., 296, 2020
6ZSI	The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Descriptor: DI(HYDROXYETHYL)ETHER, EH domain-binding protein 1, MAGNESIUM ION, ... Authors: Rai, A, Bleimling, N, Vetter, I.R, Goody, R.S. Deposit date: 2020-07-15 Release date: 2020-09-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.914 Å) Cite: The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Nat Commun, 11, 2020
6ZSJ	The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Descriptor: EH domain-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Rai, A, Bleimling, N, Vetter, I.R, Goody, R.S. Deposit date: 2020-07-15 Release date: 2020-09-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Nat Commun, 11, 2020

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