4D2G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4d2g by Molmil](/molmil-images/mine/4d2g) | Crystal structure of human PCNA in complex with p15 peptide | Descriptor: | P15, PROLIFERATING CELL NUCLEAR ANTIGEN | Authors: | DeBiasio, A, Ibanez, A, Mortuza, G, Molina, R, Cordeiro, T.N, Castillo, F, Villate, M, Merino, N, Lelli, M, Diercks, T, Luque, I, Bernardo, P, Montoya, G, Blanco, F.J. | Deposit date: | 2014-05-09 | Release date: | 2015-03-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure of P15(Paf)-PCNA Complex and Implications for Clamp Sliding During DNA Replication and Repair. Nat.Commun., 6, 2015
|
|
2B0E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2b0e by Molmil](/molmil-images/mine/2b0e) | EcoRV Restriction Endonuclease/GAAUTC/Ca2+ | Descriptor: | 5'-D(*AP*AP*AP*GP*AP*AP*(DU)P*TP*CP*TP*T)-3', CALCIUM ION, Type II restriction enzyme EcoRV | Authors: | Hiller, D.A, Rodriguez, A.M, Perona, J.J. | Deposit date: | 2005-09-13 | Release date: | 2005-09-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Non-cognate Enzyme-DNA Complex: Structural and Kinetic Analysis of EcoRV Endonuclease Bound to the EcoRI Recognition Site GAATTC J.Mol.Biol., 354, 2005
|
|
5XN1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5xn1 by Molmil](/molmil-images/mine/5xn1) | HIV-1 reverse transcriptase Q151M:DNA:entecavir-triphosphate ternary complex | Descriptor: | 38-MER DNA aptamer, GLYCEROL, MAGNESIUM ION, ... | Authors: | Yasutake, Y, Tamura, N, Hayashi, H, Maeda, K. | Deposit date: | 2017-05-17 | Release date: | 2018-02-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.446 Å) | Cite: | HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir. Sci Rep, 8, 2018
|
|
4I2H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4i2h by Molmil](/molmil-images/mine/4i2h) | Ternary complex of mouse TdT with ssDNA and AMPcPP | Descriptor: | 5'-D(P*AP*AP*AP*AP*A)-3', DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA nucleotidylexotransferase, ... | Authors: | Gouge, J, Delarue, M. | Deposit date: | 2012-11-21 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J.Mol.Biol., 425, 2013
|
|
4I27
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4i27 by Molmil](/molmil-images/mine/4i27) | Ternary complex of mouse TdT with ssDNA and incoming nucleotide | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*AP*AP*AP*AP*T)-3', DNA nucleotidylexotransferase, ... | Authors: | Gouge, J, Delarue, M. | Deposit date: | 2012-11-21 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J.Mol.Biol., 425, 2013
|
|
4PW6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pw6 by Molmil](/molmil-images/mine/4pw6) | structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II | Descriptor: | 5hmC-containing DNA1, 5hmC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | Authors: | Zhou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | Deposit date: | 2014-03-18 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.789 Å) | Cite: | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell, 54, 2014
|
|
4PW5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pw5 by Molmil](/molmil-images/mine/4pw5) | structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I | Descriptor: | 5hmC-containing DNA1, 5hmC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | Authors: | ZHou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | Deposit date: | 2014-03-18 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.204 Å) | Cite: | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell, 54, 2014
|
|
7XVA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xva by Molmil](/molmil-images/mine/7xva) | |
5XN0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5xn0 by Molmil](/molmil-images/mine/5xn0) | HIV-1 reverse transcriptase Q151M:DNA binary complex | Descriptor: | 38-MER DNA aptamer, GLYCEROL, Pol protein, ... | Authors: | Yasutake, Y, Tamura, N, Hayashi, H, Maeda, K. | Deposit date: | 2017-05-17 | Release date: | 2018-02-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.596 Å) | Cite: | HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir. Sci Rep, 8, 2018
|
|
3P87
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3p87 by Molmil](/molmil-images/mine/3p87) | Structure of human PCNA bound to RNASEH2B PIP box peptide | Descriptor: | Proliferating cell nuclear antigen, Ribonuclease H2 subunit B | Authors: | Bubeck, D, Reijns, M.A, Graham, S.C, Astell, K.R, Jones, E.Y, Jackson, A.P. | Deposit date: | 2010-10-13 | Release date: | 2011-02-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | PCNA directs type 2 RNase H activity on DNA replication and repair substrates. Nucleic Acids Res., 39, 2011
|
|
2DG6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2dg6 by Molmil](/molmil-images/mine/2dg6) | Crystal structure of the putative transcriptional regulator SCO5550 from Streptomyces coelicolor A3(2) | Descriptor: | putative transcriptional regulator | Authors: | Hayashi, T, Tanaka, Y, Sakai, N, Yao, M, Tamura, T, Tanaka, I. | Deposit date: | 2006-03-08 | Release date: | 2007-03-13 | Last modified: | 2018-03-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and genomic DNA analysis of a putative transcription factor SCO5550 from Streptomyces coelicolor A3(2): regulating the expression of gene sco5551 as a transcriptional activator with a novel dimer shape Biochem. Biophys. Res. Commun., 435, 2013
|
|
1DNO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1dno by Molmil](/molmil-images/mine/1dno) | A-DNA/RNA DODECAMER R(GCG)D(TATACGC) MG BINDING SITES | Descriptor: | DNA/RNA (5'-R(*GP*CP*GP)-D(*TP*AP*TP*AP*CP*GP*C)-3'), MAGNESIUM ION | Authors: | Robinson, H, Gao, Y.-G, Sanishvili, R, Joachimiak, A, Wang, A.H.-J. | Deposit date: | 1999-12-16 | Release date: | 2000-04-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Hexahydrated magnesium ions bind in the deep major groove and at the outer mouth of A-form nucleic acid duplexes. Nucleic Acids Res., 28, 2000
|
|
2QNC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qnc by Molmil](/molmil-images/mine/2qnc) | Crystal structure of T4 Endonuclease VII N62D mutant in complex with a DNA Holliday junction | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*DAP*DGP*DGP*DCP*DCP*DTP*DAP*DGP*DCP*DGP*DTP*DCP*DCP*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DTP*DTP*DCP*DG)-3'), DNA (5'-D(*DCP*DAP*DCP*DAP*DTP*DCP*DGP*DAP*DTP*DGP*DGP*DAP*DGP*DCP*DCP*DGP*DCP*DTP*DAP*DGP*DGP*DCP*DCP*DT)-3'), ... | Authors: | Biertumpfel, C, Yang, W, Suck, D. | Deposit date: | 2007-07-18 | Release date: | 2008-01-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of T4 endonuclease VII resolving a Holliday junction. Nature, 449, 2007
|
|
2RIQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2riq by Molmil](/molmil-images/mine/2riq) | Crystal Structure of the Third Zinc-binding domain of human PARP-1 | Descriptor: | ETHANOL, GLYCEROL, Poly [ADP-ribose] polymerase 1, ... | Authors: | Pascal, J.M, Langelier, M.F, Servent, K.M. | Deposit date: | 2007-10-12 | Release date: | 2008-01-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Third Zinc-binding Domain of Human Poly(ADP-ribose) Polymerase-1 Coordinates DNA-dependent Enzyme Activation. J.Biol.Chem., 283, 2008
|
|
1G3V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1g3v by Molmil](/molmil-images/mine/1g3v) | CRYSTAL STRUCTURE OF NICKEL-D[CGTGTACACG]2 | Descriptor: | 5'-D(*CP*GP*TP*GP*TP*AP*CP*AP*CP*G)-3', NICKEL (II) ION | Authors: | Subirana, J.A, Abrescia, N.G.A. | Deposit date: | 2000-10-25 | Release date: | 2002-01-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Nickel-guanine interactions in DNA: crystal structure of nickel-d[CGTGTACACG]2. J.Biol.Inorg.Chem., 7, 2002
|
|
6MJW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mjw by Molmil](/molmil-images/mine/6mjw) | human cGAS catalytic domain bound with the inhibitor G150 | Descriptor: | 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, Cyclic GMP-AMP synthase, ZINC ION | Authors: | Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T. | Deposit date: | 2018-09-23 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.405 Å) | Cite: | Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10, 2019
|
|
6MJU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mju by Molmil](/molmil-images/mine/6mju) | human cGAS catalytic domain bound with the inhibitor G108 | Descriptor: | 1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, Cyclic GMP-AMP synthase, ZINC ION | Authors: | Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T. | Deposit date: | 2018-09-22 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10, 2019
|
|
6MJX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mjx by Molmil](/molmil-images/mine/6mjx) | human cGAS catalytic domain bound with cGAMP | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION, cGAMP | Authors: | Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T. | Deposit date: | 2018-09-23 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10, 2019
|
|
6PLC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6plc by Molmil](/molmil-images/mine/6plc) | |
6P81
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6p81 by Molmil](/molmil-images/mine/6p81) | |
6W64
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w64 by Molmil](/molmil-images/mine/6w64) | |
5YZP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5yzp by Molmil](/molmil-images/mine/5yzp) | Crystal structure of p204 HINa domain | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Ifi204 | Authors: | Jin, T. | Deposit date: | 2017-12-15 | Release date: | 2018-12-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.581 Å) | Cite: | Structural mechanism of DNA recognition by the p204 HIN domain. Nucleic Acids Res., 2021
|
|
1SRU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sru by Molmil](/molmil-images/mine/1sru) | Crystal structure of full length E. coli SSB protein | Descriptor: | Single-strand binding protein | Authors: | Savvides, S.N, Raghunathan, S, Fuetterer, K, Kozlov, A.G, Lohman, T.M, Waksman, G. | Deposit date: | 2004-03-23 | Release date: | 2004-08-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA. Protein Sci., 13, 2004
|
|
5YZW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5yzw by Molmil](/molmil-images/mine/5yzw) | Crystal structure of p204 HINb domain | Descriptor: | Ifi204 | Authors: | Jin, T. | Deposit date: | 2017-12-15 | Release date: | 2018-12-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural mechanism of DNA recognition by the p204 HIN domain. Nucleic Acids Res., 2021
|
|
6K08
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6k08 by Molmil](/molmil-images/mine/6k08) | Crystal structure of REV7(R124A/A135D) in complex with a Shieldin3 fragment | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 | Authors: | Zhang, F, Dai, Y. | Deposit date: | 2019-05-05 | Release date: | 2019-12-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.312 Å) | Cite: | Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair. J.Biol.Chem., 295, 2020
|
|