6MJX

human cGAS catalytic domain bound with cGAMP

Summary for 6MJX

Entry DOI	10.2210/pdb6mjx/pdb
Descriptor	Cyclic GMP-AMP synthase, cGAMP, ZINC ION (3 entities in total)
Functional Keywords	human cgas, dna sensor, immune system, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	44225.87
Authors	Lama, L.,Adura, C.,Xie, W.,Tomita, D.,Kamei, T.,Kuryavyi, V.,Gogakos, T.,Steinberg, J.I.,Miller, M.,Ramos-Espiritu, L.,Asano, Y.,Hashizume, S.,Aida, J.,Imaeda, T.,Okamoto, R.,Jennings, A.J.,Michinom, M.,Kuroita, T.,Stamford, A.,Gao, P.,Meinke, P.,Glickman, J.F.,Patel, D.J.,Tuschl, T. (deposition date: 2018-09-23, release date: 2019-05-29, Last modification date: 2024-03-13)
Primary citation	Lama, L.,Adura, C.,Xie, W.,Tomita, D.,Kamei, T.,Kuryavyi, V.,Gogakos, T.,Steinberg, J.I.,Miller, M.,Ramos-Espiritu, L.,Asano, Y.,Hashizume, S.,Aida, J.,Imaeda, T.,Okamoto, R.,Jennings, A.J.,Michino, M.,Kuroita, T.,Stamford, A.,Gao, P.,Meinke, P.,Glickman, J.F.,Patel, D.J.,Tuschl, T. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10:2261-2261, 2019 Cited by PubMed: 31113940 DOI: 10.1038/s41467-019-08620-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation