6MJX
human cGAS catalytic domain bound with cGAMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 372 | 43486.0 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | B (A) | cGAMP | non-polymer | 674.4 | 1 | Chemie (1SY) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 152 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Ser 151 | - | expression tag |
| Glu 427 | Lys 427 | engineered mutation |
| Glu 428 | Lys 428 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43486.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 739.8 | |
| All* | Total formula weight | 44225.9 |
