6MJX
human cGAS catalytic domain bound with cGAMP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cyclic GMP-AMP synthase | polymer | 372 | 43486.0 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) In PDB | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
2 | A | cGAMP | non-polymer | 674.4 | 1 | Chemie (1SY) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 152 - 522 (UniProt: Q8N884)
PDB | External Database | Details |
---|---|---|
Ser 151 | - | expression tag |
Glu 427 | Lys 427 | engineered mutation |
Glu 428 | Lys 428 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 43486.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 739.8 | |
All* | Total formula weight | 44225.9 |