PDB: 1901 resultsInfo pagesStatus searchChemie searchBIRD

---

2OJ3	Hepatitis Delta Virus ribozyme precursor structure, with C75U mutation, bound to Tl+ and cobalt hexammine (Co(NH3)63+) Descriptor: COBALT HEXAMMINE(III), HDV RIBOZYME, THALLIUM (I) ION, ... Authors: Ke, A, Ding, F, Batchelor, J.D, Doudna, J.A. Deposit date: 2007-01-12 Release date: 2007-03-27 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural roles of monovalent cations in the HDV ribozyme. Structure, 15, 2007
6MEV	Structure of JMJD6 bound to Mono-Methyl Arginine. Descriptor: (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, 2-OXOGLUTARIC ACID, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, ... Authors: Lee, S, Zhang, G. Deposit date: 2018-09-07 Release date: 2019-09-18 Last modified: 2020-04-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes. Elife, 9, 2020
4LMO	Structure of a vertebrate RNA binding domain of telomerase (TRBD) Descriptor: Telomerase reverse transcriptase Authors: Harkisheimer, M, Mason, M, Shuvaeva, E, Skordalakes, E. Deposit date: 2013-07-10 Release date: 2013-10-09 Last modified: 2013-10-30 Method: X-RAY DIFFRACTION (2.37 Å) Cite: A Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity. Structure, 21, 2013
2P5P	Crystal Structure Analysis of the West Nile virus envelope (E) protein domain III Descriptor: Genome polyprotein Authors: Gao, F, Yuan, F, Gao, G.F. Deposit date: 2007-03-16 Release date: 2008-03-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure Analysis of the West Nile virus envelope (E) protein domain III To be Published
2RS3	STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES Descriptor: 5-(7-(5-HYDRO-4-ETHYL-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), ... Authors: Badger, J, Smith, T.J, Rossmann, M.G. Deposit date: 1988-10-03 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses. Proteins, 6, 1989
1EAM	VACCINIA METHYLTRANSFERASE VP39 MUTANT (EC: 2.7.7.19) Descriptor: PROTEIN (VP39), S-ADENOSYL-L-HOMOCYSTEINE Authors: Hu, G, Hodel, A.E, Gershon, P.D, Quiocho, F.A. Deposit date: 1999-01-26 Release date: 1999-06-14 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains. Proc.Natl.Acad.Sci.USA, 96, 1999
1R2P	Solution structure of domain 5 from the ai5(gamma) group II intron Descriptor: 34-MER Authors: Sigel, R.K.O, Sashital, D.G, Abramovitz, D.L, Palmer III, A.G, Butcher, S.E, Pyle, A.M. Deposit date: 2003-09-29 Release date: 2004-02-03 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif. Nat.Struct.Mol.Biol., 11, 2004
3RB9	Crystal structure of the M. tuberculosis beta clamp Descriptor: DNA polymerase III subunit beta Authors: Kukshal, V, Ramachandran, R. Deposit date: 2011-03-29 Release date: 2012-04-04 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3 Å) Cite: M. tuberculosis Sliding beta-Clamp Does Not Interact Directly with the NAD(+)-Dependent DNA Ligase Plos One, 7, 2012
7Z3P	Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution. Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ... Authors: Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K. Deposit date: 2022-03-02 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.943 Å) Cite: Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
5NAS	Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide Descriptor: 14-3-3 protein zeta/delta, Phosphatidylinositol 4-kinase beta Authors: Boura, E, Eisenreichova, A. Deposit date: 2017-02-28 Release date: 2017-03-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide To Be Published
4II5	Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... Authors: Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks III, C.L, Young, M.A. Deposit date: 2012-12-19 Release date: 2013-01-23 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE J.Am.Chem.Soc., 134, 2012
7CMW	Complex structure of PARP1 catalytic domain with pamiparib Descriptor: (2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one, GLYCEROL, Poly [ADP-ribose] polymerase 1 Authors: Feng, Y.C, Peng, H, Hong, Y, Liu, Y. Deposit date: 2020-07-29 Release date: 2020-12-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development. J.Med.Chem., 63, 2020
1R08	STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES Descriptor: 5-(5-(2,6-DICHLORO-4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)PENTYL)-3-(HYDROXYETHYL OXYMETHYLENEOXYMETHYL) ISOXAZOLE, HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), ... Authors: Badger, J, Smith, T.J, Rossmann, M.G. Deposit date: 1988-10-03 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses. Proteins, 6, 1989
8C6J	Human spliceosomal PM5 C* complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Dybkov, O, Kastner, B, Luehrmann, R. Deposit date: 2023-01-12 Release date: 2023-07-12 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins. Sci Adv, 9, 2023
9FMD	Integrative model of the human post-catalytic spliceosome (P-complex) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Rothe, P, Plaschka, C, Vorlaender, M.K. Deposit date: 2024-06-05 Release date: 2024-07-10 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Mechanism for the initiation of spliceosome disassembly. Nature, 2024
6ICZ	Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhang, X, Zhan, X, Yan, C, Shi, Y. Deposit date: 2018-09-07 Release date: 2019-03-13 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
7W59	The cryo-EM structure of human pre-C*-I complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
7W5B	The cryo-EM structure of human C* complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
7W5A	The cryo-EM structure of human pre-C*-II complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
8C42	Ternary structure of 14-3-3sigma, PKA-responsive ERa phosphopeptide and Fusicoccin-A Descriptor: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen receptor, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C43	Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. Descriptor: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8FOW	Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib Descriptor: 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... Authors: Schonbrunn, E, Sun, L. Deposit date: 2023-01-03 Release date: 2023-05-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
8FP0	Ternary complex of CDK2 with small molecule ligands TW8672 and Roscovitine Descriptor: 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, Cyclin-dependent kinase 2, ... Authors: Schonbrunn, E, Sun, L. Deposit date: 2023-01-03 Release date: 2023-05-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
6FD7	NMR structure of the first TPR domain of the human RPAP3 protein Descriptor: RNA polymerase II-associated protein 3 Authors: Quinternet, M, Chagot, M.E, Manival, X. Deposit date: 2017-12-22 Release date: 2018-08-01 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure, 26, 2018
8BJG	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 8 Descriptor: 14-3-3 protein sigma, 3-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-11-04 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

<34353637383940414243444546474849>