8K2A
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![BU of 8k2a by Molmil](/molmil-images/mine/8k2a) | Cryo-EM structure of the human 55S mitoribosome with Tigecycline | Descriptor: | 12S rRNA, 16S rRNA, 39S ribosomal protein L22, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2023-07-12 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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5WQ3
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5WA9
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![BU of 5wa9 by Molmil](/molmil-images/mine/5wa9) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Ala phosphoramidate substrate complex | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{R})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2017-06-26 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
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7M4O
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7M4M
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7M4N
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5X0I
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8BTQ
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5W77
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![BU of 5w77 by Molmil](/molmil-images/mine/5w77) | Solution structure of the MYC G-quadruplex bound to small molecule DC-34 | Descriptor: | 4-[(azepan-1-yl)methyl]-5-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]-1-benzofuran-3-carboxamide, DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION | Authors: | Chen, X, Walters, K.J. | Deposit date: | 2017-06-19 | Release date: | 2018-10-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. Nat Commun, 9, 2018
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5LT8
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7N85
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![BU of 7n85 by Molmil](/molmil-images/mine/7n85) | Inner ring spoke from the isolated yeast NPC | Descriptor: | Nucleoporin ASM4, Nucleoporin NIC96, Nucleoporin NSP1, ... | Authors: | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | Deposit date: | 2021-06-13 | Release date: | 2022-01-26 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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7N9F
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![BU of 7n9f by Molmil](/molmil-images/mine/7n9f) | Structure of the in situ yeast NPC | Descriptor: | Dynein light chain 1, cytoplasmic, Nucleoporin 145c, ... | Authors: | Villa, E, Singh, D, Ludtke, S.J, Akey, C.W, Rout, M.P, Echeverria, I, Suslov, S. | Deposit date: | 2021-06-17 | Release date: | 2022-01-26 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (37 Å) | Cite: | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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5WA8
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![BU of 5wa8 by Molmil](/molmil-images/mine/5wa8) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Ala phosphoramidate substrate complex | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{S})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2017-06-26 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
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5WAA
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![BU of 5waa by Molmil](/molmil-images/mine/5waa) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) C84R mutant | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1 | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2017-06-26 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.098 Å) | Cite: | Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia. J. Mol. Biol., 430, 2018
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7N5S
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![BU of 7n5s by Molmil](/molmil-images/mine/7n5s) | ZBTB7A Zinc Finger Domain Bound to -200 Site of Fetal Globin Promoter (Oligo 6) | Descriptor: | DNA Strand I, DNA Strand II, ZINC ION, ... | Authors: | Horton, J.R, Ren, R, Cheng, X. | Deposit date: | 2021-06-06 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Structural basis for human ZBTB7A action at the fetal globin promoter. Cell Rep, 36, 2021
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7MYF
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![BU of 7myf by Molmil](/molmil-images/mine/7myf) | Ubiquitin variant UbV.k.1 in complex with Ube2k | Descriptor: | Ubiquitin, Ubiquitin variant UbV.k.1, Ubiquitin-conjugating enzyme E2 K | Authors: | Middleton, A.J, Day, C.L, Teyra, J, Sidhu, S.S. | Deposit date: | 2021-05-21 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k. Acs Chem.Biol., 16, 2021
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7N5T
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![BU of 7n5t by Molmil](/molmil-images/mine/7n5t) | ZBTB7A Zinc Finger Domain Bound to -200 Site of Fetal Globin Promoter (Oligo 5) | Descriptor: | DNA Strand I, DNA Strand II, ZINC ION, ... | Authors: | Horton, J.R, Ren, R, Cheng, X. | Deposit date: | 2021-06-06 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for human ZBTB7A action at the fetal globin promoter. Cell Rep, 36, 2021
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7MYH
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![BU of 7myh by Molmil](/molmil-images/mine/7myh) | Ubiquitin variant UbV.k.2 in complex with Ube2k | Descriptor: | GLYCEROL, Ubiquitin variant UbV.k.2, Ubiquitin-conjugating enzyme E2 K | Authors: | Middleton, A.J, Day, C.L, Teyra, J, Sidhu, S.S. | Deposit date: | 2021-05-21 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.394 Å) | Cite: | Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k. Acs Chem.Biol., 16, 2021
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7MZT
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5X9Y
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5XIT
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![BU of 5xit by Molmil](/molmil-images/mine/5xit) | Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form II | Descriptor: | E3 ubiquitin-protein ligase RNF168, GLYCEROL, PRASEODYMIUM ION, ... | Authors: | Takahashi, T.S, Sato, Y, Fukai, S. | Deposit date: | 2017-04-27 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168. Nat Commun, 9, 2018
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5XHB
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5XHZ
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![BU of 5xhz by Molmil](/molmil-images/mine/5xhz) | Crystal Structure Analysis of CIN85-SH3B in complex with ARAP1-P2 | Descriptor: | ACETATE ION, Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, ... | Authors: | Liu, W, Yang, W. | Deposit date: | 2017-04-25 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.319 Å) | Cite: | Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85. Biochemistry, 57, 2018
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5UD8
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![BU of 5ud8 by Molmil](/molmil-images/mine/5ud8) | Crystal Structure of Mutant Ig-like Domain | Descriptor: | Triggering receptor expressed on myeloid cells 2 | Authors: | Sudom, A, Min, X, Wang, Z. | Deposit date: | 2016-12-23 | Release date: | 2018-04-04 | Last modified: | 2019-04-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J. Biol. Chem., 293, 2018
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7N5U
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![BU of 7n5u by Molmil](/molmil-images/mine/7n5u) | ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 21) | Descriptor: | DNA Strain II, DNA Strand I, ZINC ION, ... | Authors: | Horton, J.R, Ren, R, Cheng, X. | Deposit date: | 2021-06-06 | Release date: | 2022-06-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
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