5WA8

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Ala phosphoramidate substrate complex

Summary for 5WA8

Related5IPB 5IPC 5KMA 5KMB 3TW2
DescriptorHistidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{S})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywordshistidine triad, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm P49773
Total number of polymer chains2
Total molecular weight28612.07
Authors
Maize, K.M.,Finzel, B.C. (deposition date: 2017-06-26, release date: 2017-10-18, Last modification date: 2017-11-22)
Primary citation
Maize, K.M.,Shah, R.,Strom, A.,Kumarapperuma, S.,Zhou, A.,Wagner, C.R.,Finzel, B.C.
A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Mol. Pharm., 14:3987-3997, 2017
PubMed: 28968488 (PDB entries with the same primary citation)
DOI: 10.1021/acs.molpharmaceut.7b00664
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.171201.1%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-07-29