5JSB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jsb by Molmil](/molmil-images/mine/5jsb) | Crystal structure of Mcl1-inhibitor complex | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 inhibitor | Authors: | Shen, B.W, Stoddard, B.L. | Deposit date: | 2016-05-07 | Release date: | 2016-11-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
|
|
5JTB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jtb by Molmil](/molmil-images/mine/5jtb) | Crystal structure of the chimeric protein of A2aAR-BRIL with bound iodide ions | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | Authors: | Melnikov, I, Polovinkin, V, Shevtsov, M, Borshchevskiy, V, Cherezov, V, Popov, A, Gordeliy, V. | Deposit date: | 2016-05-09 | Release date: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Fast iodide-SAD phasing for high-throughput membrane protein structure determination. Sci Adv, 3, 2017
|
|
5JU8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ju8 by Molmil](/molmil-images/mine/5ju8) | Cryo-EM structure of an ErmBL-stalled ribosome in complex with P-, and E-tRNA | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Arenz, S, Bock, L.V, Graf, M, Innis, C.A, Beckmann, R, Grubmueller, H, Vaiana, A.C, Wilson, D.N. | Deposit date: | 2016-05-10 | Release date: | 2016-07-20 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. Nat Commun, 7, 2016
|
|
5MDW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mdw by Molmil](/molmil-images/mine/5mdw) | Structure of ArfA(A18T) and RF2 bound to the 70S ribosome (pre-accommodated state) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | James, N.R, Brown, A, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2016-11-13 | Release date: | 2016-12-14 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Translational termination without a stop codon. Science, 354, 2016
|
|
5MBV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mbv by Molmil](/molmil-images/mine/5mbv) | Cryo-EM structure of Lambda Phage protein GamS bound to RecBCD. | Descriptor: | Host-nuclease inhibitor protein gam, RecBCD enzyme subunit RecB, RecBCD enzyme subunit RecC, ... | Authors: | Wilkinson, M, Chaban, Y, Wigley, D.B. | Deposit date: | 2016-11-08 | Release date: | 2017-01-11 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones. Elife, 5, 2016
|
|
5NF9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nf9 by Molmil](/molmil-images/mine/5nf9) | Structure of Galectin-3 CRD in complex with compound 2 | Descriptor: | Galectin-3, ~{N}-[(2~{R},3~{R},4~{R},5~{S},6~{R})-2-acetamido-6-(hydroxymethyl)-5-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4-oxidanyl-oxan-3-yl]-3-methoxy-benzamide | Authors: | Ronin, C, Atmanene, C, Gautier, F.M, Djedaini Pilard, F, Teletchea, S, Ciesielski, F, Vivat Hannah, V, Grandjean, C. | Deposit date: | 2017-03-13 | Release date: | 2017-06-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3. Biochem. Biophys. Res. Commun., 489, 2017
|
|
5NFB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nfb by Molmil](/molmil-images/mine/5nfb) | Structure of Galectin-3 CRD in complex with compound 4 | Descriptor: | Galectin-3, ~{N}-[(2~{R},3~{R},4~{R},5~{S},6~{R})-2-acetamido-6-(hydroxymethyl)-5-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-4-[(3-methoxyphenyl)methoxy]-3,5-bis(oxidanyl)oxan-2-yl]oxy-4-oxidanyl-oxan-3-yl]-3-methoxy-benzamide | Authors: | Ronin, C, Atmanene, C, Gautier, F.M, Djedaini Pilard, F, Teletchea, S, Ciesielski, F, Vivat Hannah, V, Grandjean, C. | Deposit date: | 2017-03-13 | Release date: | 2017-06-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3. Biochem. Biophys. Res. Commun., 489, 2017
|
|
5NI4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ni4 by Molmil](/molmil-images/mine/5ni4) | |
5NP4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5np4 by Molmil](/molmil-images/mine/5np4) | |
5NPQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5npq by Molmil](/molmil-images/mine/5npq) | Human N-myristoyltransferase 1 (MNT1) with Myristoyl-CoA analogue X10 bound | Descriptor: | GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, MAGNESIUM ION, ... | Authors: | Shen, M, Perez-Dorado, I, Fedoryshchak, R, Tate, E.W. | Deposit date: | 2017-04-18 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.372 Å) | Cite: | Human N-myristoyltransferase 1 (MNT1) with Myristoyl-CoA analogue X10 bound. To be published
|
|
5KK5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kk5 by Molmil](/molmil-images/mine/5kk5) | AsCpf1(E993A)-crRNA-DNA ternary complex | Descriptor: | CRISPR-associated endonuclease Cpf1, DNA (28-MER), DNA (8-mer), ... | Authors: | Gao, P, Yang, H, Rajashankar, K.R, Huang, Z, Patel, D.J. | Deposit date: | 2016-06-21 | Release date: | 2016-08-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.289 Å) | Cite: | Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Res., 26, 2016
|
|
5NQA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nqa by Molmil](/molmil-images/mine/5nqa) | Crystal structure of GalNAc-T4 in complex with the monoglycopeptide 3 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-galactopyranose, GLYCEROL, ... | Authors: | de las Rivas, M, Lira-Navarrete, E, Daniel, E.J.P, Companon, I, Coelho, H, Diniz, A, Jimenez-Barbero, J, Peregrina, J.M, Clausen, H, Corzana, F, Marcelo, F, Jimenez-Oses, G, Gerken, T.A, Hurtado-Guerrero, R. | Deposit date: | 2017-04-19 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. Nat Commun, 8, 2017
|
|
5NR8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nr8 by Molmil](/molmil-images/mine/5nr8) | Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 7a | Descriptor: | 1-(3-azanyl-1~{H}-1,2,4-triazol-5-yl)-~{N}-[2-(4-bromophenyl)ethyl]-~{N}-methyl-piperidin-4-amine, Chitotriosidase-1, GLYCEROL | Authors: | Podjarny, A, Fadel, F, Golebiowski, A. | Deposit date: | 2017-04-22 | Release date: | 2018-02-21 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.349 Å) | Cite: | Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J. Med. Chem., 61, 2018
|
|
5KN8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kn8 by Molmil](/molmil-images/mine/5kn8) | MutY N-terminal domain in complex with undamaged DNA | Descriptor: | Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ... | Authors: | Wang, L, Chakravarthy, S, Verdine, G.L. | Deposit date: | 2016-06-27 | Release date: | 2017-02-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase. J. Biol. Chem., 292, 2017
|
|
5KNN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5knn by Molmil](/molmil-images/mine/5knn) | |
5KPV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kpv by Molmil](/molmil-images/mine/5kpv) | Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2016-07-05 | Release date: | 2016-09-28 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Ribosome•RelA structures reveal the mechanism of stringent response activation. Elife, 5, 2016
|
|
5KNL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5knl by Molmil](/molmil-images/mine/5knl) | Crystal structure of S. pombe ubiquitin E1 (Uba1) in complex with Ubc15 and ubiquitin | Descriptor: | SULFATE ION, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | Authors: | Olsen, S.K, Lv, Z, Yuan, L, Williams, K. | Deposit date: | 2016-06-28 | Release date: | 2017-02-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol. Cell, 65, 2017
|
|
5NJV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5njv by Molmil](/molmil-images/mine/5njv) | Flavivirus NS5 domain | Descriptor: | CHLORIDE ION, NS5, S-ADENOSYLMETHIONINE | Authors: | Talapatra, S.K, Chatrin, C, Kozielski, F. | Deposit date: | 2017-03-29 | Release date: | 2018-01-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping. Oncotarget, 9, 2018
|
|
5NKN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nkn by Molmil](/molmil-images/mine/5nkn) | Crystal structure of an Anticalin-colchicine complex | Descriptor: | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, Neutrophil gelatinase-associated lipocalin | Authors: | Skerra, A, Eichinger, A, Barkovskiy, M. | Deposit date: | 2017-03-31 | Release date: | 2018-04-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications. Biol. Chem., 400, 2019
|
|
5KSD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ksd by Molmil](/molmil-images/mine/5ksd) | Crystal Structure of a Plasma Membrane Proton Pump | Descriptor: | ATPase 2, plasma membrane-type, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Croll, T, Pedersen, B.P, Nissen, P. | Deposit date: | 2016-07-08 | Release date: | 2016-08-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Improved Model of Proton Pump Crystal Structure Obtained by Interactive Molecular Dynamics Flexible Fitting Expands the Mechanistic Model for Proton Translocation in P-Type ATPases. Front Physiol, 8, 2017
|
|
5NJU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nju by Molmil](/molmil-images/mine/5nju) | Flavivirus NS5 domain | Descriptor: | Genome polyprotein, MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Talapatra, S.K, Chatrin, C, Kozielski, F. | Deposit date: | 2017-03-29 | Release date: | 2018-01-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping. Oncotarget, 9, 2018
|
|
5KTE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kte by Molmil](/molmil-images/mine/5kte) | Crystal structure of Deinococcus radiodurans MntH, an Nramp-family transition metal transporter | Descriptor: | Divalent metal cation transporter MntH, Fab Heavy Chain, Fab Light Chain, ... | Authors: | Bane, L.B, Gaudet, R, Weihofen, W.A, Singharoy, A. | Deposit date: | 2016-07-11 | Release date: | 2016-11-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.941 Å) | Cite: | Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter. Structure, 24, 2016
|
|
5KW2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kw2 by Molmil](/molmil-images/mine/5kw2) | The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation | Descriptor: | (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid, Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1 | Authors: | Ho, J.D, Chau, B, Rodgers, L, Lu, F, Wilbur, K.L, Otto, K.A, Chen, Y, Song, M, Riley, J.P, Yang, H.-C, Reynolds, N.A, Kahl, S.D, Lewis, A.P, Groshong, C, Madsen, R.E, Conners, K, Linswala, J.P, Gheyi, T, Saflor, M.D, Lee, M.R, Benach, J, Baker, K.A, Montrose-Rafizadeh, C, Genin, M.J, Miller, A.R, Hamdouchi, C. | Deposit date: | 2016-07-15 | Release date: | 2018-05-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structural basis for GPR40 allosteric agonism and incretin stimulation. Nat Commun, 9, 2018
|
|
5KPW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kpw by Molmil](/molmil-images/mine/5kpw) | Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2016-07-05 | Release date: | 2016-09-28 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Ribosome•RelA structures reveal the mechanism of stringent response activation. Elife, 5, 2016
|
|
5NL2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nl2 by Molmil](/molmil-images/mine/5nl2) | cryo-EM structure of the mTMEM16A ion channel at 6.6 A resolution. | Descriptor: | Anoctamin-1 | Authors: | Paulino, C, Neldner, Y, Lam, K.M, Kalienkova, V, Brunner, J.D, Schenck, S, Dutzler, R. | Deposit date: | 2017-04-03 | Release date: | 2017-06-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A. Elife, 6, 2017
|
|