5KW2
The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation
Summary for 5KW2
Entry DOI | 10.2210/pdb5kw2/pdb |
Descriptor | Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1, (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid (3 entities in total) |
Functional Keywords | g-protein coupled receptor, free fatty acid receptor 1, lipid-binding protein, fatty acid binding protein-hydrolase complex, fatty acid binding protein/hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : O14842 |
Total number of polymer chains | 1 |
Total formula weight | 53725.97 |
Authors | Ho, J.D.,Chau, B.,Rodgers, L.,Lu, F.,Wilbur, K.L.,Otto, K.A.,Chen, Y.,Song, M.,Riley, J.P.,Yang, H.-C.,Reynolds, N.A.,Kahl, S.D.,Lewis, A.P.,Groshong, C.,Madsen, R.E.,Conners, K.,Linswala, J.P.,Gheyi, T.,Saflor, M.D.,Lee, M.R.,Benach, J.,Baker, K.A.,Montrose-Rafizadeh, C.,Genin, M.J.,Miller, A.R.,Hamdouchi, C. (deposition date: 2016-07-15, release date: 2018-05-02, Last modification date: 2023-10-04) |
Primary citation | Ho, J.D.,Chau, B.,Rodgers, L.,Lu, F.,Wilbur, K.L.,Otto, K.A.,Chen, Y.,Song, M.,Riley, J.P.,Yang, H.C.,Reynolds, N.A.,Kahl, S.D.,Lewis, A.P.,Groshong, C.,Madsen, R.E.,Conners, K.,Lineswala, J.P.,Gheyi, T.,Saflor, M.D.,Lee, M.R.,Benach, J.,Baker, K.A.,Montrose-Rafizadeh, C.,Genin, M.J.,Miller, A.R.,Hamdouchi, C. Structural basis for GPR40 allosteric agonism and incretin stimulation. Nat Commun, 9:1645-1645, 2018 Cited by PubMed: 29695780DOI: 10.1038/s41467-017-01240-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
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