8AS5
| |
6ZY7
| Cryo-EM structure of the entire Human topoisomerase II alpha in State 1 | Descriptor: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | Authors: | Vanden Broeck, A, Lamour, V. | Deposit date: | 2020-07-30 | Release date: | 2021-05-26 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.64 Å) | Cite: | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
|
|
6ZY6
| Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2 | Descriptor: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | Authors: | Vanden Broeck, A, Lamour, V. | Deposit date: | 2020-07-30 | Release date: | 2021-05-26 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
|
|
6ZY8
| Cryo-EM structure of the entire Human topoisomerase II alpha in State 2 | Descriptor: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | Authors: | Vanden Broeck, A, Lamour, V. | Deposit date: | 2020-07-30 | Release date: | 2021-05-26 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
|
|
6ZY5
| Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1 | Descriptor: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | Authors: | Vanden Broeck, A, Lamour, V. | Deposit date: | 2020-07-30 | Release date: | 2021-05-26 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
|
|
6RYU
| Nucleosome-CHD4 complex structure (two CHD4 copies) | Descriptor: | Chromodomain-helicase-DNA-binding protein 4,CHD4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | Authors: | Farnung, L, Ochmann, M, Cramer, P. | Deposit date: | 2019-06-12 | Release date: | 2020-07-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. Elife, 9, 2020
|
|
6RYR
| Nucleosome-CHD4 complex structure (single CHD4 copy) | Descriptor: | Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | Authors: | Farnung, L, Ochmann, M, Cramer, P. | Deposit date: | 2019-06-11 | Release date: | 2020-07-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. Elife, 9, 2020
|
|
6CWZ
| Crystal structure of apo SUMO E1 | Descriptor: | SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ZINC ION | Authors: | Lv, Z, Yuan, L, Atkison, J.H, Williams, K.M, Olsen, S.K. | Deposit date: | 2018-04-01 | Release date: | 2019-01-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme. Nat Commun, 9, 2018
|
|
2ASQ
| Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM) | Descriptor: | Protein inhibitor of activated STAT2, Small ubiquitin-related modifier 1 | Authors: | Song, J, Zhang, Z, Hu, W, Chen, Y. | Deposit date: | 2005-08-23 | Release date: | 2005-10-11 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif: A reversal of the bound orientation J.Biol.Chem., 280, 2005
|
|
7AAV
| Human pre-Bact-2 spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-04 | Release date: | 2020-12-09 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
|
|
7AOA
| Structure of the extended MTA1/HDAC1/MBD2/RBBP4 NURD deacetylase complex | Descriptor: | Histone deacetylase 1, Histone-binding protein RBBP4, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-10-14 | Release date: | 2020-11-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (19.4 Å) | Cite: | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
|
|
7ONB
| Structure of the U2 5' module of the A3'-SSA complex | Descriptor: | MINX, PHD finger-like domain-containing protein 5A, RNU2, ... | Authors: | Cretu, C, Pena, V. | Deposit date: | 2021-05-25 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
|
|
6P5J
| Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2) | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | Deposit date: | 2019-05-30 | Release date: | 2019-09-18 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
|
|
6P5I
| Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1) | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | Deposit date: | 2019-05-30 | Release date: | 2019-09-18 | Last modified: | 2020-02-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
|
|
7Q4O
| Substrate-bound A-like U2 snRNP | Descriptor: | BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ... | Authors: | Tholen, J, Galej, W.P. | Deposit date: | 2021-11-01 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
|
|
7Q4P
| U2 snRNP after ATP-dependent remodelling | Descriptor: | PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, Splicing factor 3A subunit 3, ... | Authors: | Tholen, J, Galej, W.P. | Deposit date: | 2021-11-01 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.15 Å) | Cite: | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
|
|
6QAJ
| Structure of the tripartite motif of KAP1/TRIM28 | Descriptor: | Endolysin,Transcription intermediary factor 1-beta, ZINC ION | Authors: | Stoll, G.A, Oda, S, Yu, M, Modis, Y. | Deposit date: | 2018-12-19 | Release date: | 2019-07-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.901 Å) | Cite: | Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
4W5V
| Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme (Uba2) ubiquitin fold domain (Ufd) | Descriptor: | FORMIC ACID, GLYCEROL, POTASSIUM ION, ... | Authors: | Boucher, L.E, Reiter, K.H, Matunis, M.J, Bosch, J. | Deposit date: | 2014-08-19 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human SUMO complex To Be Published
|
|
4WJQ
| Crystal Structure of SUMO1 in complex with Daxx | Descriptor: | Daxx, Small ubiquitin-related modifier 1 | Authors: | Cappadocia, L, Mascle, X.H, Bourdeau, V, Tremblay-Belzile, S, Chaker-Margot, M, Lussier-Price, M, Wada, J, Sakaguchi, K, Aubry, M, Ferbeyre, G, Omichinski, J.G. | Deposit date: | 2014-10-01 | Release date: | 2014-12-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1. Structure, 23, 2015
|
|
4WJN
| Crystal structure of SUMO1 in complex with phosphorylated PML | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | Authors: | Cappadocia, L, Mascle, X.H, Bourdeau, V, Tremblay-Belzile, S, Chaker-Margot, M, Lussier-Price, M, Wada, J, Sakaguchi, K, Aubry, M, Ferbeyre, G, Omichinski, J.G. | Deposit date: | 2014-10-01 | Release date: | 2014-12-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1. Structure, 23, 2015
|
|
4WJP
| Crystal Structure of SUMO1 in complex with phosphorylated Daxx | Descriptor: | Daxx, Small ubiquitin-related modifier 1 | Authors: | Cappadocia, L, Mascle, X.H, Bourdeau, V, Tremblay-Belzile, S, Chaker-Margot, M, Lussier-Price, M, Wada, J, Sakaguchi, K, Aubry, M, Ferbeyre, G, Omichinski, J.G. | Deposit date: | 2014-10-01 | Release date: | 2014-12-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1. Structure, 23, 2015
|
|
4WJO
| Crystal Structure of SUMO1 in complex with PML | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | Authors: | Cappadocia, L, Mascle, X.H, Bourdeau, V, Tremblay-Belzile, S, Chaker-Margot, M, Lussier-Price, M, Wada, J, Sakaguchi, K, Aubry, M, Ferbeyre, G, Omichinski, J.G. | Deposit date: | 2014-10-01 | Release date: | 2014-12-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1. Structure, 23, 2015
|
|
6ID0
| Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
|
|
6ID1
| Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
|
|
8D4Y
| C-terminal SANT-SLIDE domain of human Chromodomain-helicase-DNA-binding protein 4 (CHD4) | Descriptor: | Chromodomain-helicase-DNA-binding protein 4 | Authors: | Moghaddas Sani, H, Deshpande, C.N, Panjikar, S, Patel, K, Mackay, J.P. | Deposit date: | 2022-06-03 | Release date: | 2022-12-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families. Nat Commun, 13, 2022
|
|