PDB: 10243 resultsInfo pagesStatus searchChemie searchBIRD

---

5IYD	Human core-PIC in the initial transcribing state (no IIS) Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... Authors: He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. Deposit date: 2016-03-24 Release date: 2016-05-18 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
5U0S	Cryo-EM structure of the Mediator-RNAPII complex Descriptor: Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ... Authors: Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F. Deposit date: 2016-11-26 Release date: 2017-03-08 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (7.8 Å) Cite: Mediator structure and rearrangements required for holoenzyme formation. Nature, 544, 2017
7TQL	CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B. Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Lapointe, C.P, Grosely, R, Sokabe, M, Alvarado, C, Wang, J, Montabana, E, Villa, N, Shin, B, Dever, T, Fraser, C, Fernandez, I.S, Puglisi, J.D. Deposit date: 2022-01-26 Release date: 2022-04-27 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. Nature, 607, 2022
6QCX	Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer Descriptor: MAGNESIUM ION, PHOSPHATE ION, PYROPHOSPHATE 2-, ... Authors: Cusack, S, Drncova, P. Deposit date: 2018-12-31 Release date: 2019-06-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.08 Å) Cite: Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6QCV	Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP Descriptor: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Cusack, S, Drncova, P. Deposit date: 2018-12-31 Release date: 2019-06-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.24 Å) Cite: Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6QCW	Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Cusack, S, Drncova, P. Deposit date: 2018-12-31 Release date: 2019-06-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6SZV	Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only) Descriptor: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... Authors: Wandzik, J.M, Kouba, T, Cusack, S. Deposit date: 2019-10-02 Release date: 2020-04-15 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
7ZPL	Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook Descriptor: 5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ... Authors: Cusack, S, Kouba, T. Deposit date: 2022-04-27 Release date: 2022-12-28 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
6T0V	Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase) Descriptor: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... Authors: Wandzik, J.M, Kouba, T, Cusack, S. Deposit date: 2019-10-03 Release date: 2020-04-15 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (3.02 Å) Cite: A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
7OO3	Pol II-CSB-CSA-DDB1-UVSSA (Structure1) Descriptor: CSB element, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ... Authors: Kokic, G, Cramer, P. Deposit date: 2021-05-26 Release date: 2021-10-06 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
7OOB	Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2) Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA damage-binding protein 1, ... Authors: Kokic, G, Cramer, P. Deposit date: 2021-05-27 Release date: 2021-10-13 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
8WAV	De novo transcribing complex 12 (TC12), the early elongation complex with Pol II positioned 12nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAX	De novo transcribing complex 14 (TC14), the early elongation complex with Pol II positioned 14nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.75 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAW	De novo transcribing complex 13 (TC13), the early elongation complex with Pol II positioned 13nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (3.02 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAY	De novo transcribing complex 15 (TC15), the early elongation complex with Pol II positioned 15nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAZ	De novo transcribing complex 16 (TC16), the early elongation complex with Pol II positioned 16nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAT	De novo transcribing complex 10 (TC10), the early elongation complex with Pol II positioned 10nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.82 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WB0	De novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAU	De novo transcribing complex 11 (TC11), the early elongation complex with Pol II positioned 11nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.78 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
7R1F	Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106 Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... Authors: Cusack, S, Kouba, T. Deposit date: 2022-02-02 Release date: 2022-12-28 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (2.58 Å) Cite: Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7QTL	Influenza A/H7N9 polymerase elongation complex Descriptor: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... Authors: Cusack, S, Kouba, T. Deposit date: 2022-01-14 Release date: 2022-12-28 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (2.48 Å) Cite: Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7R0E	Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... Authors: Cusack, S, Kouba, T. Deposit date: 2022-02-01 Release date: 2022-12-28 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7KHE	Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp Descriptor: CHAPSO, DNA (46-MER), DNA (54-MER), ... Authors: Shin, Y, Qayyum, M.Z, Murakami, K.S. Deposit date: 2020-10-21 Release date: 2020-12-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
6OW3	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1T Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*GP*AP*TP*CP*TP*GP*AP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*TP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2019-05-09 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.766 Å) Cite: Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6P71	X-ray crystal structure of a bacterial reiterative transcription complex of pyrBI promoter Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*CP*GP*AP*GP*CP*CP*GP*GP*GP*A)-3'), DNA (5'-D(P*CP*TP*CP*CP*CP*GP*GP*CP*AP*AP*AP*TP*TP*GP*T)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2019-06-04 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020

<27282930313233343536373839404142>