Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8XGT
DownloadVisualize
BU of 8xgt by Molmil
Crystal structure of human secretory glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-hydroxyindolin-2-one
Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-oxidanyl-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-15
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XBS
DownloadVisualize
BU of 8xbs by Molmil
C. elegans apo-SID1 structure
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gong, D.S.
Deposit date:2023-12-07
Release date:2024-06-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.21 Å)
Cite:Structural basis for double-stranded RNA recognition by SID1.
Nucleic Acids Res., 52, 2024
9LDB
DownloadVisualize
BU of 9ldb by Molmil
DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK
Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ...
Authors:Dunn, C.R, Holbrook, J.J, Muirhead, H.
Deposit date:1991-11-26
Release date:1993-10-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philos.Trans.R.Soc.London,Ser.B, 332, 1991
9LDT
DownloadVisualize
BU of 9ldt by Molmil
DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK
Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ...
Authors:Dunn, C.R, Holbrook, J.J, Muirhead, H.
Deposit date:1991-11-26
Release date:1993-10-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philos.Trans.R.Soc.London,Ser.B, 332, 1991
8XC1
DownloadVisualize
BU of 8xc1 by Molmil
C. elegans SID1 in complex with dsRNA
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gong, D.S.
Deposit date:2023-12-07
Release date:2024-06-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.21 Å)
Cite:Structural basis for double-stranded RNA recognition by SID1.
Nucleic Acids Res., 52, 2024
8XGB
DownloadVisualize
BU of 8xgb by Molmil
Crystal structure of human secretory glutaminyl cyclase in complex with (S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
Descriptor: (5~{S})-1-(3~{H}-benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-15
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XGY
DownloadVisualize
BU of 8xgy by Molmil
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one
Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-16
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
7QTT
DownloadVisualize
BU of 7qtt by Molmil
Structural organization of a late activated human spliceosome (Baqr, core region)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Cretu, C, Pena, V.
Deposit date:2022-01-15
Release date:2023-05-10
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of catalytic activation in human splicing.
Nature, 617, 2023
3CZ2
DownloadVisualize
BU of 3cz2 by Molmil
Dimeric crystal structure of a pheromone binding protein from Apis mellifera at pH 7.0
Descriptor: CHLORIDE ION, Pheromone-binding protein ASP1
Authors:Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C.
Deposit date:2008-04-27
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release
J.Mol.Biol., 390, 2009
4U28
DownloadVisualize
BU of 4u28 by Molmil
Crystal structure of apo Phosphoribosyl isomerase A from Streptomyces sviceus ATCC 29083
Descriptor: PHOSPHATE ION, Phosphoribosyl isomerase A
Authors:Chang, C, Verduzco-Castro, E.A, Endres, M, Barona-Gomez, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-07-16
Release date:2014-07-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop.
Biochem. J., 473, 2016
4U3B
DownloadVisualize
BU of 4u3b by Molmil
LpxC from A.Aaeolicus in complex with the MMP inhibitor 4-[[4-(4-chlorophenoxy)phenyl]sulfanylmethyl]tetrahydropyran-4-carbohydroxamic acid - compound 2
Descriptor: 4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide, CHLORIDE ION, IMIDAZOLE, ...
Authors:Olivier, N.B.
Deposit date:2014-07-19
Release date:2014-10-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.
Acs Med.Chem.Lett., 5, 2014
7R1U
DownloadVisualize
BU of 7r1u by Molmil
Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the WZ16 inhibitor
Descriptor: (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Klima, M, Boura, E, Li, F, Yazdi, A.K, Vedadi, M.
Deposit date:2022-02-03
Release date:2022-06-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
Protein Sci., 31, 2022
7R1T
DownloadVisualize
BU of 7r1t by Molmil
Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the SS148 inhibitor
Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Klima, M, Boura, E, Li, F, Yazdi, A.K, Vedadi, M.
Deposit date:2022-02-03
Release date:2022-06-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
Protein Sci., 31, 2022
7R9X
DownloadVisualize
BU of 7r9x by Molmil
Crystal structure of a dehydrating condensation domain, AmbE-CmodAA, involved in nonribosomal peptide synthesis
Descriptor: AmbE, IODIDE ION, SODIUM ION
Authors:Fortinez, C.M, Schmeing, T.M.
Deposit date:2021-06-29
Release date:2022-07-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis.
J.Am.Chem.Soc., 144, 2022
4U3D
DownloadVisualize
BU of 4u3d by Molmil
LpxC from A.Aaeolicus in complex with 4-[[4-[2-[4-(morpholinomethyl)phenyl]ethynyl]phenoxy]methyl]tetrahydropyran-4-carbohydroxamic acid (compound 9)
Descriptor: CHLORIDE ION, IMIDAZOLE, N-hydroxy-4-[(4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}phenoxy)methyl]tetrahydro-2H-pyran-4-carboxamide, ...
Authors:Olivier, N.B.
Deposit date:2014-07-19
Release date:2014-10-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.
Acs Med.Chem.Lett., 5, 2014
4TX9
DownloadVisualize
BU of 4tx9 by Molmil
Crystal structure of HisAp from Streptomyces sviceus with degraded ProFAR
Descriptor: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Phosphoribosyl isomerase A, SULFATE ION
Authors:Michalska, K, Verduzco-Castro, E.A, Endres, M, Barona-Gomez, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-07-02
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop.
Biochem. J., 473, 2016
7RW2
DownloadVisualize
BU of 7rw2 by Molmil
Cryo-EM structure of NTD-directed neutralizing antibody 5-7 in complex with prefusion SARS-CoV-2 spike glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-7 heavy chain, ...
Authors:Cerutti, G, Shapiro, L.
Deposit date:2021-08-19
Release date:2021-09-01
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain.
Cell Rep, 37, 2021
4U9B
DownloadVisualize
BU of 4u9b by Molmil
Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II)NO ligation state
Descriptor: GLYCEROL, NITRIC OXIDE, NO-binding heme-dependent sensor protein, ...
Authors:Herzik Jr, M.A, Jonnalagadda, R, Kuriyan, J, Marletta, M.A.
Deposit date:2014-08-05
Release date:2014-10-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UUK
DownloadVisualize
BU of 4uuk by Molmil
Human dynamin 1 K44A superconstricted polymer stabilized with GTP strand 2
Descriptor: DYNAMIN-1
Authors:Sundborger, A.C, Fang, S, Heymann, J.A, Ray, P, Chappie, J.S, Hinshaw, J.E.
Deposit date:2014-07-29
Release date:2014-08-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (12.5 Å)
Cite:A Dynamin Mutant Defines a Superconstricted Prefission State.
Cell Rep., 8, 2014
4W9T
DownloadVisualize
BU of 4w9t by Molmil
Crystal structure of HisAP from Streptomyces sp. Mg1
Descriptor: Phosphoribosyl isomerase A, SULFATE ION
Authors:MICHALSKA, K, VERDUZCO-CASTRO, E.A, ENDRES, M, BARONA-GOMEZ, F, JOACHIMIAK, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-08-27
Release date:2014-09-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop.
Biochem. J., 473, 2016
7SJ0
DownloadVisualize
BU of 7sj0 by Molmil
Antibody A7V3 bound to N-terminal domain of the spike
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, A7V3 Fab heavy chain, A7V3 Fab light chain, ...
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2021-10-15
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Antibody A7V3 bound to N-terminal domain of the spike
To Be Published
7TAA
DownloadVisualize
BU of 7taa by Molmil
FAMILY 13 ALPHA AMYLASE IN COMPLEX WITH ACARBOSE
Descriptor: CALCIUM ION, MODIFIED ACARBOSE HEXASACCHARIDE, TAKA AMYLASE
Authors:Davies, G.J, Brzozowski, A.M.
Deposit date:1997-10-06
Release date:1998-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure of the Aspergillus oryzae alpha-amylase complexed with the inhibitor acarbose at 2.0 A resolution.
Biochemistry, 36, 1997
7T5F
DownloadVisualize
BU of 7t5f by Molmil
Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10
Descriptor: Botulinum neurotoxin type B, IODIDE ION, JLJ-G3, ...
Authors:Jin, R, Lam, K.-H.
Deposit date:2021-12-12
Release date:2021-12-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
7SXI
DownloadVisualize
BU of 7sxi by Molmil
Solution Structure of Sds3 Capped Tudor Domain
Descriptor: Sin3 histone deacetylase corepressor complex component SDS3
Authors:Marcum, R.D, Radhakrishnan, I.
Deposit date:2021-11-23
Release date:2022-01-19
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:A capped Tudor domain within a core subunit of the Sin3L/Rpd3L histone deacetylase complex binds to nucleic acid G-quadruplexes.
J.Biol.Chem., 298, 2022
7ROQ
DownloadVisualize
BU of 7roq by Molmil
Alternative Structure of Human ABCA1
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Aller, S.G.
Deposit date:2021-08-01
Release date:2022-01-19
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Refined ABCA1 with Domain-swapped Regulatory Domains
Plos One, 2022

222415

数据于2024-07-10公开中

PDB statisticsPDBj update infoContact PDBjnumon