7R1T

Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the SS148 inhibitor

Summary for 7R1T

Entry DOI	10.2210/pdb7r1t/pdb
Descriptor	2'-O-methyltransferase nsp16, Non-structural protein 10, (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ... (7 entities in total)
Functional Keywords	methyltransferase, nsp10, nsp16, inhibitor, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	2
Total formula weight	47536.95
Authors	Klima, M.,Boura, E.,Li, F.,Yazdi, A.K.,Vedadi, M. (deposition date: 2022-02-03, release date: 2022-06-29, Last modification date: 2024-01-31)
Primary citation	Klima, M.,Khalili Yazdi, A.,Li, F.,Chau, I.,Hajian, T.,Bolotokova, A.,Kaniskan, H.U.,Han, Y.,Wang, K.,Li, D.,Luo, M.,Jin, J.,Boura, E.,Vedadi, M. Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Sci., 31:e4395-e4395, 2022 Cited by PubMed: 36040262 DOI: 10.1002/pro.4395 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation