4U3D
LpxC from A.Aaeolicus in complex with 4-[[4-[2-[4-(morpholinomethyl)phenyl]ethynyl]phenoxy]methyl]tetrahydropyran-4-carbohydroxamic acid (compound 9)
Summary for 4U3D
Entry DOI | 10.2210/pdb4u3d/pdb |
Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, IMIDAZOLE, ZINC ION, ... (6 entities in total) |
Functional Keywords | antibacterial, lpxc, gram negative bacteria, mmp, hydrophobe, hydrolase |
Biological source | Aquifex aeolicus |
Total number of polymer chains | 1 |
Total formula weight | 31675.39 |
Authors | Olivier, N.B. (deposition date: 2014-07-19, release date: 2014-10-01, Last modification date: 2023-12-20) |
Primary citation | Murphy-Benenato, K.E.,Olivier, N.,Choy, A.,Ross, P.L.,Miller, M.D.,Thresher, J.,Gao, N.,Hale, M.R. Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. Acs Med.Chem.Lett., 5:1213-1218, 2014 Cited by PubMed: 25408833DOI: 10.1021/ml500210x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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