Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7K7L
DownloadVisualize
BU of 7k7l by Molmil
Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
Descriptor: 3-benzyl-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Spurlino, J.C, Milligan, C.
Deposit date:2020-09-23
Release date:2020-10-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.539 Å)
Cite:Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.
Bioorg.Med.Chem.Lett., 30, 2020
2O3B
DownloadVisualize
BU of 2o3b by Molmil
Crystal structure complex of Nuclease A (NucA) with intra-cellular inhibitor NuiA
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, NICKEL (II) ION, ...
Authors:Ghosh, M, Meiss, G, Pingoud, A.M, London, R.E, Pedersen, L.C.
Deposit date:2006-12-01
Release date:2006-12-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The nuclease a-inhibitor complex is characterized by a novel metal ion bridge.
J.Biol.Chem., 282, 2007
2YNO
DownloadVisualize
BU of 2yno by Molmil
yeast betaprime COP 1-304H6
Descriptor: COATOMER SUBUNIT BETA', POLY ALA
Authors:Jackson, L.P, Lewis, M, Kent, H.M, Edeling, M.A, Evans, P.R, Duden, R, Owen, D.J.
Deposit date:2012-10-17
Release date:2012-12-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis for Recognition of Dilysine Trafficking Motifs by Copi.
Dev.Cell, 23, 2012
2O85
DownloadVisualize
BU of 2o85 by Molmil
S. Aureus thioredoxin P31T mutant
Descriptor: Thioredoxin
Authors:Roos, G, Loris, R, Messens, J.
Deposit date:2006-12-12
Release date:2007-07-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The conserved active site proline determines the reducing power of Staphylococcus aureus thioredoxin
J.Mol.Biol., 368, 2007
7K7Z
DownloadVisualize
BU of 7k7z by Molmil
Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
Descriptor: 3-benzyl-7-(1H-pyrazol-4-yl)quinazolin-4(3H)-one, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Spurlino, J.C, Milligan, C.
Deposit date:2020-09-24
Release date:2020-10-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.606087 Å)
Cite:Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.
Bioorg.Med.Chem.Lett., 30, 2020
7LS1
DownloadVisualize
BU of 7ls1 by Molmil
80S ribosome from mouse bound to eEF2 (Class II)
Descriptor: 28S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T.
Deposit date:2021-02-17
Release date:2021-11-03
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Nat Commun, 12, 2021
7LS2
DownloadVisualize
BU of 7ls2 by Molmil
80S ribosome from mouse bound to eEF2 (Class I)
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T.
Deposit date:2021-02-17
Release date:2021-11-03
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Nat Commun, 12, 2021
7K5I
DownloadVisualize
BU of 7k5i by Molmil
SARS-COV-2 nsp1 in complex with human 40S ribosome
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Wang, L, Shi, M, Wu, H.
Deposit date:2020-09-16
Release date:2020-10-14
Last modified:2021-03-17
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
Biorxiv, 2020
6CEQ
DownloadVisualize
BU of 6ceq by Molmil
The Aer2 Receptor from Vibrio cholerae is a Dual PAS-Heme Oxygen Sensor
Descriptor: Methyl-accepting chemotaxis protein, PROTOPORPHYRIN IX CONTAINING FE
Authors:Crane, B.R, Chua, T.K, Sukomon, N.
Deposit date:2018-02-12
Release date:2018-05-16
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:THE AER2 RECEPTOR FROM VIBRIO CHOLERAE IS A DUAL PAS-HEME OXYGEN SENSOR.
Mol. Microbiol., 2018
2O9R
DownloadVisualize
BU of 2o9r by Molmil
beta-glucosidase B complexed with thiocellobiose
Descriptor: Beta-glucosidase B, beta-D-glucopyranose-(1-4)-4-thio-beta-D-glucopyranose
Authors:Isorna, P, Polaina, J, Sanz-Aparicio, J.
Deposit date:2006-12-14
Release date:2007-10-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Paenibacillus polymyxa beta-Glucosidase B Complexes Reveal the Molecular Basis of Substrate Specificity and Give New Insights into the Catalytic Machinery of Family I Glycosidases
J.Mol.Biol., 371, 2007
2O9T
DownloadVisualize
BU of 2o9t by Molmil
beta-glucosidase B from Bacillus polymyxa complexed with glucose
Descriptor: Beta-glucosidase B, beta-D-glucopyranose
Authors:Isorna, P, Polaina, J, Sanz-Aparicio, J.
Deposit date:2006-12-14
Release date:2007-10-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structures of Paenibacillus polymyxa beta-Glucosidase B Complexes Reveal the Molecular Basis of Substrate Specificity and Give New Insights into the Catalytic Machinery of Family I Glycosidases
J.Mol.Biol., 371, 2007
2OGQ
DownloadVisualize
BU of 2ogq by Molmil
Molecular and structural basis of Plk1 substrate recognition: Implications in centrosomal localization
Descriptor: Serine/threonine-protein kinase PLK1
Authors:Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G.
Deposit date:2007-01-08
Release date:2007-02-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3AZZ
DownloadVisualize
BU of 3azz by Molmil
Crystal structure of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with gluconolactone
Descriptor: CALCIUM ION, D-glucono-1,5-lactone, Laminarinase, ...
Authors:Jeng, W.Y, Wang, N.C, Wang, A.H.J.
Deposit date:2011-06-03
Release date:2011-11-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for beta-1,3 and beta-1,4 glucan selection.
J.Biol.Chem., 286, 2011
2P5J
DownloadVisualize
BU of 2p5j by Molmil
sPLA2 inhibitor pip 17
Descriptor: pip17
Authors:Thwin, M.M, Satyanarayanajois, D.S, Nagarajarao, L.M, Sato, K, Gopalakrishnakone, P.P, Arjunan, P.
Deposit date:2007-03-15
Release date:2007-11-13
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Novel Peptide Inhibitors of Human Secretory Phospholipase A2 with Antiinflammatory Activity: Solution Structure and Molecular Modeling.
J.Med.Chem., 50, 2007
2PBI
DownloadVisualize
BU of 2pbi by Molmil
The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure
Descriptor: GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9
Authors:Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J.
Deposit date:2007-03-28
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
6NK0
DownloadVisualize
BU of 6nk0 by Molmil
EphA2 LBD in complex with bA-WLA-Yam peptide
Descriptor: 1,2-ETHANEDIOL, 6-AMINOHEXANOIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6HJY
DownloadVisualize
BU of 6hjy by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72
Descriptor: Cys-loop ligand-gated ion channel, nanobody 72
Authors:Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6HA1
DownloadVisualize
BU of 6ha1 by Molmil
Cryo-EM structure of a 70S Bacillus subtilis ribosome translating the ErmD leader peptide in complex with telithromycin
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Crowe-McAuliffe, C, Graf, M, Huter, P, Abdelshahid, M, Novacek, J, Wilson, D.N.
Deposit date:2018-08-07
Release date:2018-08-29
Last modified:2021-01-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for antibiotic resistance mediated by theBacillus subtilisABCF ATPase VmlR.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3AZX
DownloadVisualize
BU of 3azx by Molmil
Crystal structure of the laminarinase catalytic domain from Thermotoga maritima MSB8
Descriptor: CALCIUM ION, Laminarinase
Authors:Jeng, W.Y, Wang, N.C, Wang, A.H.J.
Deposit date:2011-06-03
Release date:2011-11-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for beta-1,3 and beta-1,4 glucan selection.
J.Biol.Chem., 286, 2011
3B01
DownloadVisualize
BU of 3b01 by Molmil
Crystal structure of the laminarinase catalytic domain from Thermotoga maritima MSB8
Descriptor: CALCIUM ION, CHLORIDE ION, Laminarinase, ...
Authors:Jeng, W.Y, Wang, N.C, Wang, A.H.J.
Deposit date:2011-06-03
Release date:2011-11-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for beta-1,3 and beta-1,4 glucan selection.
J.Biol.Chem., 286, 2011
2O7K
DownloadVisualize
BU of 2o7k by Molmil
S. aureus thioredoxin
Descriptor: Thioredoxin
Authors:Roos, G, Garcia-Pino, A, Van Belle, K, Brosens, E, Wahni, K, Vandenbussche, G, Wyns, L, Loris, R, Messens, J.
Deposit date:2006-12-11
Release date:2007-07-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The conserved active site proline determines the reducing power of Staphylococcus aureus thioredoxin
J.Mol.Biol., 368, 2007
2OAJ
DownloadVisualize
BU of 2oaj by Molmil
Crystal structure of Sro7 from S. cerevisiae
Descriptor: Protein SNI1, SODIUM ION, ZINC ION
Authors:Hattendorf, D.A, Weis, W.I.
Deposit date:2006-12-15
Release date:2007-04-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism.
Nature, 446, 2007
2OJX
DownloadVisualize
BU of 2ojx by Molmil
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
Descriptor: Serine/threonine-protein kinase PLK1, Synthetic peptide
Authors:Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G.
Deposit date:2007-01-15
Release date:2007-02-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
Proc.Natl.Acad.Sci.Usa, 104, 2007
6JWN
DownloadVisualize
BU of 6jwn by Molmil
Crystal structure of the SPRY domain of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interaction
Descriptor: Nitric oxide synthase, inducible, SPRY domain-containing SOCS box protein 2
Authors:Li, K, Kuang, Z.
Deposit date:2019-04-21
Release date:2020-04-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal structure of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interaction
To Be Published
3AZY
DownloadVisualize
BU of 3azy by Molmil
Crystal structure of the laminarinase catalytic domain from Thermotoga maritima MSB8
Descriptor: CALCIUM ION, Laminarinase, SULFATE ION
Authors:Jeng, W.Y, Wang, N.C, Wang, A.H.J.
Deposit date:2011-06-03
Release date:2011-11-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for beta-1,3 and beta-1,4 glucan selection.
J.Biol.Chem., 286, 2011

224572

数据于2024-09-04公开中

PDB statisticsPDBj update infoContact PDBjnumon