8FCK
 
 | | Structure of the vertebrate augmin complex | | Descriptor: | HAUS augmin like complex subunit 2 L homeolog, Green fluorescent protein chimera, HAUS augmin like complex subunit 4 L homeolog, ... | | Authors: | Travis, S.M, Huang, W, Zhang, R, Petry, S. | | Deposit date: | 2022-12-01 | | Release date: | 2023-04-19 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (6.88 Å) | | Cite: | Integrated model of the vertebrate augmin complex.
Nat Commun, 14, 2023
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7FHO
 | | Structure of AtTPC1 D240A/D454A/E528A mutant with 50 mM Ca2+ | | Descriptor: | CALCIUM ION, Two pore calcium channel protein 1,GFP | | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | | Deposit date: | 2021-07-29 | | Release date: | 2021-12-01 | | Last modified: | 2022-03-16 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHL
 | | Structure of AtTPC1 with 50 mM Ca2+ | | Descriptor: | AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP | | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | | Deposit date: | 2021-07-29 | | Release date: | 2021-12-01 | | Last modified: | 2022-03-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHK
 | | Structure of AtTPC1 with 1 mM Ca2+ | | Descriptor: | AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP | | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | | Deposit date: | 2021-07-29 | | Release date: | 2021-12-01 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6RMG
 | | Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Korkhov, V.M, Qi, C. | | Deposit date: | 2019-05-06 | | Release date: | 2019-10-09 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of sterol recognition by human hedgehog receptor PTCH1.
Sci Adv, 5, 2019
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3EK7
 | | Calcium-saturated GCaMP2 dimer | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Akerboom, J, Velez Rivera, J.D, Looger, L.L, Schreiter, E.R. | | Deposit date: | 2008-09-18 | | Release date: | 2008-12-16 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
J.Biol.Chem., 284, 2009
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8TLM
 | | Structure of a class A GPCR/Fab complex | | Descriptor: | C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ... | | Authors: | Sun, D, Johnson, M, Masureel, M. | | Deposit date: | 2023-07-27 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
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6DEJ
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6HR1
 | | Crystal structure of the YFPnano fusion protein | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Benoit, R.M. | | Deposit date: | 2018-09-26 | | Release date: | 2020-04-08 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Chimeric single alpha-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology.
Structure, 2021
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8HTT
 | | Cryo-EM structure of human TMEM87A, gluconate-bound | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-gluconic acid, Transmembrane protein 87A,EGFP, ... | | Authors: | Han, A, Kim, H.M. | | Deposit date: | 2022-12-21 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of human TMEM87A, PE-bound
To Be Published
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5OOZ
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5OQE
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5OQ9
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3SG4
 | | Crystal Structure of GCaMP3-D380Y, LP(linker 2) | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Schreiter, E.R, Akerboom, J, Looger, L.L. | | Deposit date: | 2011-06-14 | | Release date: | 2012-06-20 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Optimization of a GCaMP calcium indicator for neural activity imaging.
J.Neurosci., 32, 2012
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3SG3
 | | Crystal Structure of GCaMP3-D380Y | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Schreiter, E.R, Akerboom, J, Looger, L.L. | | Deposit date: | 2011-06-14 | | Release date: | 2012-06-20 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Optimization of a GCaMP calcium indicator for neural activity imaging.
J.Neurosci., 32, 2012
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3SG2
 | | Crystal Structure of GCaMP2-T116V,D381Y | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Schreiter, E.R, Akerboom, J, Looger, L.L. | | Deposit date: | 2011-06-14 | | Release date: | 2012-06-20 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Optimization of a GCaMP calcium indicator for neural activity imaging.
J.Neurosci., 32, 2012
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3SG6
 | | Crystal Structure of Dimeric GCaMP2-LIA(linker 1) | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Schreiter, E.R, Akerboom, J, Looger, L.L. | | Deposit date: | 2011-06-14 | | Release date: | 2012-06-20 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Optimization of a GCaMP calcium indicator for neural activity imaging.
J.Neurosci., 32, 2012
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3SG7
 | | Crystal Structure of GCaMP3-KF(linker 1) | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Schreiter, E.R, Akerboom, J, Looger, L.L. | | Deposit date: | 2011-06-14 | | Release date: | 2012-06-20 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Optimization of a GCaMP calcium indicator for neural activity imaging.
J.Neurosci., 32, 2012
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3SG5
 | | Crystal Structure of Dimeric GCaMP3-D380Y, QP(linker 1), LP(linker 2) | | Descriptor: | CALCIUM ION, GLYCEROL, Myosin light chain kinase, ... | | Authors: | Schreiter, E.R, Akerboom, J, Looger, L.L. | | Deposit date: | 2011-06-14 | | Release date: | 2012-06-20 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Optimization of a GCaMP calcium indicator for neural activity imaging.
J.Neurosci., 32, 2012
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5OQA
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8JU6
 | | Structure of human TRPV4 with antagonist GSK279 | | Descriptor: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-24 | | Release date: | 2024-05-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JU5
 | | Structure of human TRPV4 with antagonist A1 | | Descriptor: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-24 | | Release date: | 2024-05-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JVI
 | | Structure of human TRPV4 with antagonist A2 | | Descriptor: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-28 | | Release date: | 2024-05-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JVJ
 | | Structure of human TRPV4 with antagonist A2 and RhoA | | Descriptor: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-28 | | Release date: | 2024-05-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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3WLD
 | | Crystal structure of monomeric GCaMP6m | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Ding, J, Luo, A.F, Hu, L.Y, Wang, D.C, Shao, F. | | Deposit date: | 2013-11-08 | | Release date: | 2014-01-22 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis of the ultrasensitive calcium indicator GCaMP6.
Sci China Life Sci, 57, 2014
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