3KB5
 
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7BRE
 | | The crystal structure of MLL2 in complex with ASH2L and RBBP5 | | Descriptor: | Histone-lysine N-methyltransferase 2B, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Li, Y, Zhao, L, Chen, Y. | | Deposit date: | 2020-03-28 | | Release date: | 2020-07-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.803 Å) | | Cite: | Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.
Structure, 28, 2020
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5LYG
 | | CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A1 BOUND TO MALONATE | | Descriptor: | 1,2-ETHANEDIOL, Butyrophilin subfamily 3 member A1, MALONATE ION | | Authors: | Mohammed, F, Baker, A.T, Salim, M, Willcox, B.E. | | Deposit date: | 2016-09-28 | | Release date: | 2017-09-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | BTN3A1 Discriminates gamma delta T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.
ACS Chem. Biol., 12, 2017
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4N7U
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4N7I
 | | Crystal Structure of Intracellular B30.2 Domain of BTN3A1 | | Descriptor: | BETA-MERCAPTOETHANOL, Butyrophilin subfamily 3 member A1, CHLORIDE ION, ... | | Authors: | Sandstrom, A, Adams, E.J. | | Deposit date: | 2013-10-15 | | Release date: | 2014-04-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.4015 Å) | | Cite: | The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human V gamma 9V delta 2 T Cells.
Immunity, 40, 2014
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3ZO0
 | | Mouse IgG2a in complex with mouse TRIM21 PRYSPRY | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE TRIM21, IG GAMMA-2A CHAIN C REGION, A ALLELE, ... | | Authors: | James, L.C. | | Deposit date: | 2013-02-19 | | Release date: | 2013-05-22 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Trim21 is an Igg Receptor that is Structurally, Thermodynamically, and Kinetically Conserved.
Proc.Natl.Acad.Sci.USA, 105, 2008
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2FBE
 | | Crystal Structure of the PRYSPRY-domain | | Descriptor: | PREDICTED: similar to ret finger protein-like 1 | | Authors: | Gruetter, C, Briand, C, Capitani, G, Mittl, P.R, Gruetter, M.G. | | Deposit date: | 2005-12-09 | | Release date: | 2006-01-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Structure of the PRYSPRY-domain: Implications for autoinflammatory diseases
Febs Lett., 580, 2006
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2VOK
 | | Murine TRIM21 | | Descriptor: | 52 KDA RO PROTEIN | | Authors: | Keeble, A.H, Khan, Z, Forster, A, James, L.C. | | Deposit date: | 2008-02-19 | | Release date: | 2008-04-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Trim21 is an Igg Receptor that is Structurally, Thermodynamically, and Kinetically Conserved.
Proc.Natl.Acad.Sci.USA, 105, 2008
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2IWG
 | | COMPLEX BETWEEN THE PRYSPRY DOMAIN OF TRIM21 AND IGG FC | | Descriptor: | 52 KDA RO PROTEIN, IG GAMMA-1 CHAIN C, alpha-L-fucopyranose, ... | | Authors: | James, L.C, Keeble, A.H, Rhodes, D.A, Trowsdale, J. | | Deposit date: | 2006-06-30 | | Release date: | 2007-03-27 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural Basis for Pryspry-Mediated Tripartite Motif (Trim) Protein Function.
Proc.Natl.Acad.Sci.USA, 104, 2007
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2WL1
 | | Pyrin PrySpry domain | | Descriptor: | 1,2-ETHANEDIOL, PYRIN, THIOCYANATE ION | | Authors: | Weinert, C, Mittl, P.R, Gruetter, M.G. | | Deposit date: | 2009-06-19 | | Release date: | 2009-10-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | The Crystal Structure of Human Pyrin B30.2 Domain: Implications for Mutations Associated with Familial Mediterranean Fever.
J.Mol.Biol., 394, 2009
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4WVM
 | | Stonustoxin structure | | Descriptor: | Stonustoxin subunit alpha, Stonustoxin subunit beta | | Authors: | Ellisdon, A.M, Panjikar, S, Whisstock, J.C, McGowan, S. | | Deposit date: | 2014-11-06 | | Release date: | 2015-12-02 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Stonefish toxin defines an ancient branch of the perforin-like superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4B3N
 | | Crystal structure of rhesus TRIM5alpha PRY/SPRY domain | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MALTOSE-BINDING PERIPLASMIC PROTEIN, TRIPARTITE MOTIF-CONTAINING PROTEIN 5, ... | | Authors: | Yang, H, Ji, X, Zhao, Q, Xiong, Y. | | Deposit date: | 2012-07-25 | | Release date: | 2012-10-24 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural Insight Into HIV-1 Capsid Recognition by Rhesus Trim5Alpha
Proc.Natl.Acad.Sci.USA, 109, 2012
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4CG4
 | | Crystal structure of the CHS-B30.2 domains of TRIM20 | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-ETHANETHIOL, PYRIN, ... | | Authors: | Weinert, C, Morger, D, Djekic, A, Mittl, P.R.E, Gruetter, M.G. | | Deposit date: | 2013-11-20 | | Release date: | 2015-04-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structure of Trim20 C-Terminal Coiled-Coil/B30.2 Fragment: Implications for the Recognition of Higher Order Oligomers
Sci.Rep., 5, 2015
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4CFG
 | | Structure of the TRIM25 coiled-coil | | Descriptor: | E3 UBIQUITIN/ISG15 LIGASE TRIM25 | | Authors: | James, L. | | Deposit date: | 2013-11-15 | | Release date: | 2014-12-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the Trim25 Coiled-Coil
To be Published
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4B8E
 | | PRY-SPRY domain of Trim25 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN/ISG15 LIGASE TRIM25 | | Authors: | Kershaw, N.J, D'Cruz, A.A, Nicola, N.A, Nicholson, S.E, Babon, J.J. | | Deposit date: | 2012-08-27 | | Release date: | 2013-09-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.779 Å) | | Cite: | Crystal Structure of the Trim25 B30.2 (Pryspry) Domain: A Key Component of Antiviral Signaling.
Biochem.J., 456, 2013
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5HM7
 | | The Intracellular domain of Butyrophilin 3A1 protein | | Descriptor: | BETA-MERCAPTOETHANOL, Butyrophilin subfamily 3 member A1, GLYCEROL, ... | | Authors: | Adams, E.J, Gu, S. | | Deposit date: | 2016-01-15 | | Release date: | 2017-07-26 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V gamma 9V delta 2 T cell activation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5F6L
 | | The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | | Descriptor: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Li, Y, Lei, M, Chen, Y. | | Deposit date: | 2015-12-06 | | Release date: | 2016-02-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
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5F6K
 | | Crystal structure of the MLL3-Ash2L-RbBP5 complex | | Descriptor: | Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Li, Y, Lei, M, Chen, Y. | | Deposit date: | 2015-12-06 | | Release date: | 2016-02-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.411 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
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6UMA
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6UMB
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7XZ0
 | | TRIM E3 ubiquitin ligase | | Descriptor: | Tripartite motif-containing protein 72, ZINC ION | | Authors: | Park, S.H, Song, H.K. | | Deposit date: | 2022-06-02 | | Release date: | 2023-07-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.28 Å) | | Cite: | Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Nat.Struct.Mol.Biol., 30, 2023
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7Y4S
 | | Structure of human MG53 homo-dimer | | Descriptor: | Tripartite motif-containing protein 72 | | Authors: | Chen, L, Niu, Y. | | Deposit date: | 2022-06-16 | | Release date: | 2022-09-21 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structure of human MG53 homodimer.
Biochem.J., 479, 2022
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7Y3A
 | | Crystal structure of TRIM7 bound to 2C | | Descriptor: | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-2C | | Authors: | Dong, C, Yan, X. | | Deposit date: | 2022-06-10 | | Release date: | 2022-08-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y3B
 | | Crystal structure of TRIM7 bound to GN1 | | Descriptor: | E3 ubiquitin-protein ligase TRIM7,TRIM7-GN1 | | Authors: | Dong, C, Yan, X. | | Deposit date: | 2022-06-10 | | Release date: | 2022-08-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y3C
 | | Crystal structure of TRIM7 bound to RACO-1 | | Descriptor: | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-RACO-1 | | Authors: | Dong, C, Yan, X. | | Deposit date: | 2022-06-10 | | Release date: | 2022-08-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7.
Proc.Natl.Acad.Sci.USA, 119, 2022
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