6CM3
 
 | | BG505 SOSIP in complex with sCD4, 17b, 8ANC195 | | Descriptor: | 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wang, H, Bjorkman, P.J. | | Deposit date: | 2018-03-02 | | Release date: | 2018-10-17 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.
Cell Host Microbe, 24, 2018
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1OLZ
 | | The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D | | Descriptor: | SEMAPHORIN 4D | | Authors: | Love, C.A, Harlos, K, Mavaddat, N, Davis, S.J, Stuart, D.I, Jones, E.Y, Esnouf, R.M. | | Deposit date: | 2003-08-19 | | Release date: | 2003-09-11 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Ligand-Binding Face of the Semaphorins Revealed by the High-Resolution Crystal Structure of Sema4D
Nat.Struct.Biol., 10, 2003
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3CD4
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8IOW
 | | Cryo-EM structure of the sarilumab Fab/IL-6R complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Sarilumab Fab, Interleukin-6 receptor subunit alpha, ... | | Authors: | She, J, Chen, L, Wang, M.X. | | Deposit date: | 2023-03-13 | | Release date: | 2024-03-20 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into IL-6 signaling inhibition by therapeutic antibodies.
Cell Rep, 43, 2024
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6GRQ
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6DLF
 | | Crystal structure of NTRI homodimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neurotrimin | | Authors: | Ranaivoson, F.M, Turk, L.S, Ozkan, E, Montelione, G.T, Comoletti, D. | | Deposit date: | 2018-06-01 | | Release date: | 2019-04-10 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.446 Å) | | Cite: | Structure of a heterodimer of neuronal cell surface proteins
Structure, 2019
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8FYJ
 | | Structure of HIV-1 BG505 SOSIP-HT2 in complex with two CD4 molecules (class I) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | Authors: | Fan, C, Dam, K.A, Bjorkman, P.J. | | Deposit date: | 2023-01-26 | | Release date: | 2023-10-18 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.
Nature, 623, 2023
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8FYI
 | | Structure of HIV-1 BG505 SOSIP-HT1 in complex with one CD4 molecule | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(6-8)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Fan, C, Dam, K.A, Bjorkman, P.J. | | Deposit date: | 2023-01-26 | | Release date: | 2023-10-18 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.
Nature, 623, 2023
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3CHN
 | | Solution structure of human secretory IgA1 | | Descriptor: | Ig alpha-1 chain C region, Immunoglobulin kappa light chain, Secretory component | | Authors: | Bonner, A, Almogren, A, Furtado, P.B, Kerr, M.A, Perkins, S.J. | | Deposit date: | 2008-03-10 | | Release date: | 2008-12-30 | | Last modified: | 2024-02-21 | | Method: | SOLUTION SCATTERING | | Cite: | Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity.
Mucosal Immunol, 2, 2009
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4LIQ
 | | Structure of the extracellular domain of human CSF-1 receptor in complex with the Fab fragment of RG7155 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab fragment RG7155 heavy chain, Fab fragment RG7155 light chain, ... | | Authors: | Benz, J, Gorr, I.H, Hertenberger, H, Ries, C.H. | | Deposit date: | 2013-07-03 | | Release date: | 2014-06-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
Cancer Cell, 25, 2014
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3EJJ
 | | Structure of M-CSF bound to the first three domains of FMS | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Colony stimulating factor-1, Macrophage colony-stimulating factor 1 receptor | | Authors: | Chen, X, Liu, H, Focia, P.J, Shim, A, He, X. | | Deposit date: | 2008-09-18 | | Release date: | 2008-12-09 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.
Proc.Natl.Acad.Sci.USA, 105, 2008
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6EDU
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5IHB
 | | Structure of the immune receptor CD33 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Myeloid cell surface antigen CD33 | | Authors: | Dodd, R.B. | | Deposit date: | 2016-02-29 | | Release date: | 2017-03-29 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structure of ligand bound CD33 receptor associated with Alzheimer's disease
To Be Published
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6X5B
 | | Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52 | | Descriptor: | 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ozorowski, G, Torres, J.L, Ward, A.B. | | Deposit date: | 2020-05-25 | | Release date: | 2020-10-21 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Cell Rep, 33, 2020
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6L1Y
 | | structure of gp120/CD4 with a non-canonical surface | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, T-cell surface glycoprotein CD4, ... | | Authors: | Liu, X, Ning, W. | | Deposit date: | 2019-10-01 | | Release date: | 2020-05-20 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.469 Å) | | Cite: | A non-canonical binding interface in the crystal structure of HIV-1 gp120 core in complex with CD4.
Sci Rep, 7, 2017
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5J06
 | | Structure of the immune receptor CD33 in complex with 3'-sialyllactose | | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Myeloid cell surface antigen CD33, ... | | Authors: | Dodd, R.B. | | Deposit date: | 2016-03-27 | | Release date: | 2017-04-05 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | STRUCTURE OF LIGAND BOUND CD33 RECEPTOR ASSOCIATED WITH ALZHEIMER'S DISEASE
To Be Published
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5VN3
 | | Cryo-EM model of B41 SOSIP.664 in complex with soluble CD4 (D1-D2) and fragment antigen binding variable domain of 17b | | Descriptor: | 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ozorowski, G, Pallesen, J, Ward, A.B. | | Deposit date: | 2017-04-28 | | Release date: | 2017-07-12 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.
Nature, 547, 2017
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5VI4
 | | IL-33/ST2/IL-1RAcP ternary complex structure | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 receptor accessory protein, Interleukin-1 receptor-like 1, ... | | Authors: | Guenther, S, Sundberg, E.J. | | Deposit date: | 2017-04-13 | | Release date: | 2017-09-27 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.792 Å) | | Cite: | IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor.
Immunity, 47, 2017
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1RZK
 | | HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | | Authors: | Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D. | | Deposit date: | 2003-12-24 | | Release date: | 2004-02-03 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101, 2004
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8GRX
 | | APOE4 receptor in complex with APOE4 NTD | | Descriptor: | Apolipoprotein E, Leukocyte immunoglobulin-like receptor subfamily A member 6 | | Authors: | Zhou, J, Wang, Y, Huang, G, Shi, Y. | | Deposit date: | 2022-09-02 | | Release date: | 2023-07-05 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | LilrB3 is a putative cell surface receptor of APOE4.
Cell Res., 33, 2023
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5J0B
 | | Structure of the immune receptor CD33 in complex with 6'-sialyllactose | | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Myeloid cell surface antigen CD33, ... | | Authors: | Dodd, R.B. | | Deposit date: | 2016-03-28 | | Release date: | 2017-04-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | STRUCTURE OF LIGAND BOUND CD33 RECEPTOR ASSOCIATED WITH ALZHEIMER'S DISEASE
To Be Published
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4N8V
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6X5C
 | | Asymmetric model of CD4-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | Authors: | Ozorowski, G, Torres, J.L, Ward, A.B. | | Deposit date: | 2020-05-25 | | Release date: | 2020-10-21 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.04 Å) | | Cite: | A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Cell Rep, 33, 2020
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4H8W
 | | Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4. | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, ... | | Authors: | Tolbert, W.D, Acharya, P, Kwong, P.D, Pazgier, M. | | Deposit date: | 2012-09-24 | | Release date: | 2014-04-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
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1OW0
 | | Crystal structure of human FcaRI bound to IgA1-Fc | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Ig alpha-1 chain C region, Immunoglobulin alpha Fc receptor, ... | | Authors: | Herr, A.B, Ballister, E.R, Bjorkman, P.J. | | Deposit date: | 2003-03-27 | | Release date: | 2003-05-27 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Insights into IgA-mediated immune responses from the crystal structures of human Fc-alpha-RI and its complex with IgA1-Fc
Nature, 423, 2003
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