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2R99
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Crystal structure of cyclophilin ABH-like domain of human peptidylprolyl isomerase E isoform 1
Descriptor: Peptidyl-prolyl cis-trans isomerase E
Authors:Walker, J.R, Davis, T, Newman, E.M, Mackenzie, F, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2007-09-12
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
3NXT
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Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase
Descriptor: 5-[(E)-2-cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Cody, V.
Deposit date:2010-07-14
Release date:2010-12-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 66, 2010
4H10
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BU of 4h10 by Molmil
Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic Helix-Loop-Helix domains with E-box DNA
Descriptor: Aryl hydrocarbon receptor nuclear translocator-like protein 1, Circadian locomoter output cycles protein kaput, E-box DNA antisense strand, ...
Authors:Wang, Z, Su, X.-D.
Deposit date:2012-09-10
Release date:2012-12-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.
Cell Res., 23, 2013
4NFT
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BU of 4nft by Molmil
Crystal structure of human lnkH2B-h2A.Z-Anp32e
Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member E, Histone H2B type 2-E, Histone H2A.Z
Authors:Shan, S, Pan, L, Mao, Z, Wang, W, Sun, J, Dong, Q, Liang, X, Ding, X, Chen, S, Dai, L, Zhang, Z, Zhu, B, Zhou, Z.
Deposit date:2013-11-01
Release date:2014-04-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z
Cell Res., 24, 2014
2JSS
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BU of 2jss by Molmil
NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B
Descriptor: Chimera of Histone H2B.1 and Histone H2A.Z, Uncharacterized protein YER030W
Authors:Zhou, Z, Feng, H, Hansen, D.F, Kato, H, Luk, E, Freedberg, D.I, Kay, L.E, Wu, C, Bai, Y.
Deposit date:2007-07-11
Release date:2008-05-20
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
Nat.Struct.Mol.Biol., 15, 2008
6AE8
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BU of 6ae8 by Molmil
Structure insight into histone chaperone Chz1-mediated H2A.Z recognition and replacement
Descriptor: BICINE, Histone H2A.Z-specific chaperone CHZ1, Histone H2B.1,Histone H2A.Z
Authors:Wang, Y.Y, Shan, S, Zhou, Z.
Deposit date:2018-08-03
Release date:2019-04-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement.
Plos Biol., 17, 2019
1KMV
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BU of 1kmv by Molmil
HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE
Descriptor: (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, DIHYDROFOLATE REDUCTASE, DIMETHYL SULFOXIDE, ...
Authors:Klon, A.E, Heroux, A, Ross, L.J, Pathak, V, Johnson, C.A, Piper, J.R, Borhani, D.W.
Deposit date:2001-12-17
Release date:2002-07-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.
J.Mol.Biol., 320, 2002
2OSE
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BU of 2ose by Molmil
Crystal Structure of the Mimivirus Cyclophilin
Descriptor: CHLORIDE ION, Probable peptidyl-prolyl cis-trans isomerase
Authors:Eisenmesser, E.Z, Thai, V, Renesto, P, Raoult, D.
Deposit date:2007-02-05
Release date:2007-12-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus.
J.Mol.Biol., 378, 2008
7X6V
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BU of 7x6v by Molmil
lymphocytic choriomeningitis virus polymerase- Matrix Z Protein Complex (LCMV L-Z Complex)
Descriptor: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ...
Authors:Liu, L, Lou, Z.
Deposit date:2022-03-08
Release date:2023-09-13
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein.
Protein Cell, 14, 2023
7EJU
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BU of 7eju by Molmil
Junin virus(JUNV) RNA polymerase L complexed with Z protein
Descriptor: MAGNESIUM ION, RING finger protein Z, RNA-directed RNA polymerase L, ...
Authors:Chen, Y.
Deposit date:2021-04-02
Release date:2021-07-07
Last modified:2025-06-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for recognition and regulation of arenavirus polymerase L by Z protein.
Nat Commun, 12, 2021
3CZJ
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BU of 3czj by Molmil
E. COLI (lacZ) BETA-GALACTOSIDASE (N460T) IN COMPLEX WITH D-GALCTOPYRANOSYL-1-ONE
Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ...
Authors:Huber, R.E, Dugdale, M.L, Fraser, M.E, Tammam, S.D.
Deposit date:2008-04-29
Release date:2009-04-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Practical Considerations When Using Temperature to Obtain Rate Constants and Activation Thermodynamics of Enzymes with Two Catalytic Steps: Native and N460T-beta-Galactosidase (E. coli) as Examples.
Protein J., 28, 2009
2IPO
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BU of 2ipo by Molmil
E. coli Aspartate Transcarbamoylase complexed with N-phosphonacetyl-L-asparagine
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
Authors:Cardia, J.P, Eldo, J, Xia, J, O'Day, E.M, Tsuruta, H, Kantrowitz, E.R.
Deposit date:2006-10-12
Release date:2007-08-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Use of L-asparagine and N-phosphonacetyl-L-asparagine to investigate the linkage of catalysis and homotropic cooperativity in E. coli aspartate transcarbomoylase.
Proteins, 71, 2008
7NIY
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BU of 7niy by Molmil
E. coli NfsA with FMN
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Day, M.D, Jarrom, D, Hyde, E.I, White, S.A.
Deposit date:2021-02-14
Release date:2021-07-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Biochem.J., 478, 2021
7NNX
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BU of 7nnx by Molmil
E. coli NfsA with 1,4-benzoquinone
Descriptor: 1,2-ETHANEDIOL, 1,4-benzoquinone, CHLORIDE ION, ...
Authors:Day, M.D, Jarrom, D, Hyde, E.I, White, S.A.
Deposit date:2021-02-25
Release date:2021-07-21
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Biochem.J., 478, 2021
7NMP
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BU of 7nmp by Molmil
E. coli NfsA with hydroquinone
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Day, M.D, Jarrom, D, Parr, R.J, Hyde, E.I, White, S.A.
Deposit date:2021-02-23
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Biochem.J., 478, 2021
8BWC
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BU of 8bwc by Molmil
E. coli BAM complex (BamABCDE) wild-type
Descriptor: Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ...
Authors:Machin, J.M, Radford, S.E, Ranson, N.A.
Deposit date:2022-12-06
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Darobactin B Stabilises a Lateral-Closed Conformation of the BAM Complex in E. coli Cells.
Angew.Chem.Int.Ed.Engl., 62, 2023
5MV2
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BU of 5mv2 by Molmil
Crystal structure of the E protein of the Japanese encephalitis live attenuated vaccine virus
Descriptor: E protein
Authors:Liu, X, Zhao, X, Na, R, Li, L, Warkentin, E, Witt, J, Lu, X, Wei, Y, Peng, G, Li, Y, Wang, J.
Deposit date:2017-01-14
Release date:2018-05-23
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism.
Protein Cell, 10, 2019
8X1Z
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BU of 8x1z by Molmil
HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y:DNA:E-CFCP-TP ternary complex
Descriptor: DNA/RNA (38-MER), E-CFCP-triphosphate, GLYCEROL, ...
Authors:Yasutake, Y, Hattori, S.I, Mitsuya, H.
Deposit date:2023-11-09
Release date:2024-07-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations.
Sci Rep, 14, 2024
8X20
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BU of 8x20 by Molmil
HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/L74V:DNA:E-CFCP-TP ternary complex
Descriptor: DNA/RNA (38-MER), E-CFCP-triphosphate, GLYCEROL, ...
Authors:Yasutake, Y, Hattori, S.I, Mitsuya, H.
Deposit date:2023-11-09
Release date:2024-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations.
Sci Rep, 14, 2024
6FH8
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BU of 6fh8 by Molmil
E. coli surface display of streptavidin for directed evolution of an allylic deallocase
Descriptor: Streptavidin, biotinylated ruthenium cyclopentadienide
Authors:Heinisch, T, Schwizer, F, Garabedian, B, Csibra, E, Jeschek, M, Pinheiro Bernhardes, V, Marliere, P, Panke, S, Ward, T.R.
Deposit date:2018-01-12
Release date:2018-08-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:E. colisurface display of streptavidin for directed evolution of an allylic deallylase.
Chem Sci, 9, 2018
7P2X
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BU of 7p2x by Molmil
E.coli GyrB24 with inhibitor KOB20 (EBL2583)
Descriptor: (2Z)-2-[[4,5-bis(bromanyl)-1H-pyrrol-2-yl]carbonylimino]-3-(phenylmethyl)-1,3-benzothiazole-6-carboxylic acid, DNA gyrase subunit B, PHOSPHATE ION
Authors:Stevenson, C.E.M, Lawson, D.M, Maxwell, A.M, Henderson, S.R, Kikelj, D, Benek, O, Zega, A, Zidar, N, Ilas, J, Tomasic, T, Masic, L.P.
Deposit date:2021-07-06
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:E.coli GyrB24 with inhibitor KOB20 (EBL2583)
TO BE PUBLISHED
8QPO
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BU of 8qpo by Molmil
E. coli NfsB with the unnatural amino acid p-nitrophenylalanine at position 124.
Descriptor: ACETATE ION, FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase
Authors:Day, M.A, White, S.A, Hyde, E.I.
Deposit date:2023-10-02
Release date:2024-08-14
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:E. coli NfsB with unnatural amino acids at position 124.
To Be Published
8R18
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BU of 8r18 by Molmil
Pim1 in complex with (E)-4-(4-hydroxystyryl)benzoic acid and Pimtide
Descriptor: (E)-4-(4-hydroxystyryl)benzoic acid, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Hochban, P.M.M, Heine, A, Diederich, W.E.
Deposit date:2023-11-01
Release date:2024-03-20
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:What doesn't fit is made to fit: Pim-1 kinase adapts to the configuration of stilbene-based inhibitors.
Arch Pharm, 357, 2024
5NJB
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BU of 5njb by Molmil
E. coli Microcin-processing metalloprotease TldD/E with actinonin bound
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACTINONIN, ...
Authors:Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJ5
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E. coli Microcin-processing metalloprotease TldD/E with phosphate bound
Descriptor: 1,2-ETHANEDIOL, Metalloprotease PmbA, Metalloprotease TldD, ...
Authors:Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017

238582

数据于2025-07-09公开中

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