8R18

Pim1 in complex with (E)-4-(4-hydroxystyryl)benzoic acid and Pimtide

Summary for 8R18

• Entry DOI: 10.2210/pdb8r18/pdb
• Related: 7QB2 7QFM 7Z6U 8AFR 8R0H 8R0Q 8R0W 8R0Y 8R10
• Descriptor: Serine/threonine-protein kinase pim-1, Pimtide, GLYCEROL, ... (6 entities in total)
• Functional Keywords: serine kinase, kinase, complex, pim1, pim, pim-1, inhibitor, tumorigenisis, cancer, pimtide, proto oncogen, atp, phosphorylation, apoptosis, cell cycle, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 37657.74

Authors

Hochban, P.M.M.,Heine, A.,Diederich, W.E. (deposition date: 2023-11-01, release date: 2024-03-20, Last modification date: 2024-06-12)

• Primary citation: Hochban, P.M.M.,Heyder, L.,Heine, A.,Diederich, W.E.; What doesn't fit is made to fit: Pim-1 kinase adapts to the configuration of stilbene-based inhibitors.; Arch Pharm, 357:e2400094-e2400094, 2024; PubMed: 38631036; DOI: 10.1002/ardp.202400094

Experimental method

X-RAY DIFFRACTION (1.89 Å)