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7RL6
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BU of 7rl6 by Molmil
Cryo-EM structure of human p97-R155H mutant bound to ADP.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLF
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BU of 7rlf by Molmil
Cryo-EM structure of human p97-E470D mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLD
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BU of 7rld by Molmil
Cryo-EM structure of human p97-E470D mutant bound to ADP.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RL7
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BU of 7rl7 by Molmil
Cryo-EM structure of human p97-R155H mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLJ
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BU of 7rlj by Molmil
Cryo-EM structure of human p97 bound to CB-5083 and ATPgS.
Descriptor: 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLI
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BU of 7rli by Molmil
Cryo-EM structure of human p97 bound to CB-5083 and ADP.
Descriptor: 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7QO5
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BU of 7qo5 by Molmil
26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state
Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ...
Authors:Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, T.C, Joshi, T, Rudack, T, Sakata, E, Finley, D.
Deposit date:2021-12-23
Release date:2022-03-16
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
Nat Commun, 13, 2022
7KSL
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BU of 7ksl by Molmil
Substrate-free human mitochondrial LONP1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial
Authors:Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C.
Deposit date:2020-11-23
Release date:2020-12-09
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
7KSM
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BU of 7ksm by Molmil
Human mitochondrial LONP1 with endogenous substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ...
Authors:Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C.
Deposit date:2020-11-23
Release date:2020-12-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
7KRZ
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BU of 7krz by Molmil
Human mitochondrial LONP1 in complex with Bortezomib
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ...
Authors:Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C.
Deposit date:2020-11-20
Release date:2021-02-24
Last modified:2022-06-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
7L6N
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BU of 7l6n by Molmil
The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with three locally refined ClpB middle domains and three DnaK nucleotide binding domains
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, Chaperone protein DnaK, ...
Authors:Yin, Y.Y, Feng, X, Li, H.
Deposit date:2020-12-23
Release date:2021-05-26
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
7L5W
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BU of 7l5w by Molmil
p97-R155H mutant dodecamer I
Descriptor: Transitional endoplasmic reticulum ATPase
Authors:Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
Deposit date:2020-12-23
Release date:2021-08-04
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7L5X
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BU of 7l5x by Molmil
p97-R155H mutant dodecamer II
Descriptor: Transitional endoplasmic reticulum ATPase
Authors:Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
Deposit date:2020-12-23
Release date:2021-08-04
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7L9P
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BU of 7l9p by Molmil
Structure of human SHLD2-SHLD3-REV7-TRIP13(E253Q) complex
Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Pachytene checkpoint protein 2 homolog, ...
Authors:Xie, W, Patel, D.J.
Deposit date:2021-01-04
Release date:2021-03-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LMZ
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BU of 7lmz by Molmil
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7LN4
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BU of 7ln4 by Molmil
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 3)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7LMY
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BU of 7lmy by Molmil
Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6
Descriptor: 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7LN2
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BU of 7ln2 by Molmil
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7LN0
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BU of 7ln0 by Molmil
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7LN6
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BU of 7ln6 by Molmil
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 2, Open State)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7MCA
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BU of 7mca by Molmil
Structure of the S. cerevisiae origin recognition complex bound to the replication initiator Cdc6 and the ARS1 origin DNA.
Descriptor: Cell division control protein 6, DNA (85-MER), MAGNESIUM ION, ...
Authors:Feng, X, Li, H.
Deposit date:2021-04-01
Release date:2021-06-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
Nat Commun, 12, 2021
7LN5
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BU of 7ln5 by Molmil
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 1, Close State)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7LN1
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BU of 7ln1 by Molmil
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 3)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7LN3
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BU of 7ln3 by Molmil
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pan, M, Yu, Y, Liu, L, Zhao, M.
Deposit date:2021-02-06
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
7MDO
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BU of 7mdo by Molmil
Structure of human p97 ATPase L464P mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Zhang, X, Gui, L, Li, S, Nandi, P, Columbres, R.C, Wong, D.E, Moen, D.R, Lin, H.J, Chiu, P.-L, Chou, T.-F.
Deposit date:2021-04-05
Release date:2021-08-25
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity.
Biochem.J., 478, 2021

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数据于2024-09-18公开中

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