7RLI

Cryo-EM structure of human p97 bound to CB-5083 and ADP.

Summary for 7RLI

• Entry DOI: 10.2210/pdb7rli/pdb
• EMDB information: 24531
• Descriptor: Transitional endoplasmic reticulum ATPase, 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
• Functional Keywords: p97, vcp, tera, inhibitor, cb-5083, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 12
• Total formula weight: 1104867.85

Authors

Caffrey, B.,Zhu, X.,Berezuk, A.,Tuttle, K.,Chittori, S.,Subramaniam, S. (deposition date: 2021-07-23, release date: 2021-09-22, Last modification date: 2024-06-05)

• Primary citation: Caffrey, B.,Zhu, X.,Berezuk, A.,Tuttle, K.,Chittori, S.,Subramaniam, S.; AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.; J.Biol.Chem., 297:101187-101187, 2021; PubMed: 34520757; DOI: 10.1016/j.jbc.2021.101187

Experimental method

ELECTRON MICROSCOPY (3.1 Å)