7RLJ

Cryo-EM structure of human p97 bound to CB-5083 and ATPgS.

Summary for 7RLJ

Entry DOI	10.2210/pdb7rlj/pdb
EMDB information	24532
Descriptor	Transitional endoplasmic reticulum ATPase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	p97, vcp, tera, inhibitor, cb-5083, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	12
Total formula weight	1026057.01
Authors	Caffrey, B.,Zhu, X.,Berezuk, A.,Tuttle, K.,Chittori, S.,Subramaniam, S. (deposition date: 2021-07-23, release date: 2021-09-22, Last modification date: 2021-11-17)
Primary citation	Caffrey, B.,Zhu, X.,Berezuk, A.,Tuttle, K.,Chittori, S.,Subramaniam, S. AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. J.Biol.Chem., 297:101187-101187, 2021 Cited by PubMed: 34520757 DOI: 10.1016/j.jbc.2021.101187 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation