7LMY

Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6

Summary for 7LMY

• Entry DOI: 10.2210/pdb7lmy/pdb
• EMDB information: 23442 23443 23444 23445 23446 23447 23448 23449 23450 23451 23452 23453 23454 23455 23456 23457 23458
• Descriptor: Transitional endoplasmic reticulum ATPase, ADENOSINE-5'-TRIPHOSPHATE, 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ... (4 entities in total)
• Functional Keywords: p97, nms-873, single-particle cryo-em, translocation, allosteric inhibition, translocase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 546464.94

Authors

Pan, M.,Yu, Y.,Liu, L.,Zhao, M. (deposition date: 2021-02-06, release date: 2021-09-15)

• Primary citation: Pan, M.,Yu, Y.,Ai, H.,Zheng, Q.,Xie, Y.,Liu, L.,Zhao, M.; Mechanistic insight into substrate processing and allosteric inhibition of human p97.; Nat.Struct.Mol.Biol., 28:614-625, 2021; PubMed: 34262183; DOI: 10.1038/s41594-021-00617-2

Experimental method

ELECTRON MICROSCOPY (2.4 Å)